The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Immune function of astrocytes
Abstract
Astrocytes are the major glial cell within the central nervous system (CNS) and have a number of important physiological properties related to CNS homeostasis. The aspect of astrocyte biology addressed in this review article is the astrocyte as an immunocompetent cell within the brain. The capacity of astrocytes to express class II major histocompatibility complex (MHC) antigens and costimulatory molecules (B7 and CD40) that are critical for antigen presentation and T‐cell activation are discussed. The functional role of astrocytes as immune effector cells and how this may influence aspects of inflammation and immune reactivity within the brain follows, emphasizing the involvement of astrocytes in promoting Th2 responses. The ability of astrocytes to produce a wide array of chemokines and cytokines is discussed, with an emphasis on the immunological properties of these mediators. The significance of astrocytic antigen presentation and chemokine/cytokine production to neurological diseases with an immunological component is described. GLIA 36:180–190, 2001. © 2001 Wiley‐Liss, Inc.
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Cites
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
CD28/B7 SYSTEM OF T CELL COSTIMULATION
Lenschow, D. J., Walunas, T. L., & Bluestone, J. A. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.233 · Cited by 2,717
Ransohoff, R. M., Hamilton, T. A., Tani, M., Stoler, M. H., Shick, H. E., Major, J. A., Estes, M. L., Thomas, D. M., & Tuohy, V. K. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.6.8472896 · Cited by 496
Transcriptional regulation of Th1/Th2 polarization
Rengarajan, J., Szabo, S. J., & Glimcher, L. H. (2000) · Immunology Today · doi:10.1016/s0167-5699(00)01712-6 · Cited by 433
Cited by
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196
Interactions between the microbiota, immune and nervous systems in health and disease
Fung, T. C., Olson, C. A., & Hsiao, E. Y. (2017) · Nature Neuroscience · doi:10.1038/nn.4476 · Cited by 1,900
Netland, J., Meyerholz, D. K., Moore, S., Cassell, M., & Perlman, S. (2008) · Journal of Virology · doi:10.1128/jvi.00737-08 · Cited by 1,293
Astrocytes are active players in cerebral innate immunity
Farina, C., Aloisi, F., & Meinl, E. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.01.005 · Cited by 1,304
Sofroniew, M. V. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020420 · Cited by 695
Metadata
- Authors
- Dong, Y., & Benveniste, E. N.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2001-10-02
- Volume
- 36
- Issue
- 2
- Pages
- 180-190
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W2051947267
- Cited by
- 1,293
- References
- 4
- FWCI
- 20.21
- Type
- journal article
- Language
- en
- Open access
- closed
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