Increased expression of the astrocytic glutamate transporter GLT‐1 in the prefrontal cortex of schizophrenics
Abstract
To verify whether altered glial glutamate uptake contributes to the reduced efficacy of glutamatergic transmission reported in the prefrontal cortex of schizophrenics, we studied the expression of GLT-1, the transporter responsible for most glutamate transport, in autoptic samples of prefrontal cortex using real time quantitative RT-PCR, immunocytochemistry, and functional assays. GLT-1 mRNA levels in medication-free patients were 2.5-fold higher than in controls, whereas they were normal or reduced in patients treated with antipsychotics. We also observed a 4-fold increase in L-[(3)H]-Glu uptake in Xenopus oocytes injected with mRNA from the prefrontal cortex of a medication-free schizophrenic and a 2-fold increase in GLT-1 protein in the same cortical area of another medication-free patient. Results suggest that GLT-1 mRNA, protein and function are increased in prefrontal cortex of schizophrenics.
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Glia are involved in a variety of neurological diseases, including schizophrenia, autism spectrum disorders, epilepsy, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, and stroke.
“Accumulating evidence has demonstrated that glia are involved in a variety of neurological diseases, including schizophrenia, autism spectrum disorders, epilepsy, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, and stroke (Matute et al., 2005;Tian et al., 2005;Nagai et al., 2007;Chen et al., 2009;Li et al., 2011;Lioy et al., 2011;Molofsky et al., 2012;Z”
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- Authors
- Matute, C., Melone, M., Vallejo‐Illarramendi, A., & Conti, F.
- Affiliations
- University of the Basque Country (ES)
- Marche Polytechnic University (IT)
- Corresponding author
- Conti, Fiorenzo
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2004-10-19
- Volume
- 49
- Issue
- 3
- Pages
- 451-455
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W2080865236
- Cited by
- 129
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 2 · 2017: 7 · 2016: 1 · 2015: 11 · 2014: 11 · 2013: 6 · 2012: 9
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Glia (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- GLT-1, glutamate transporters, schizophrenia, prefrontal cortex, astrocytes, glutamate uptake, antipsychotic drugs, glutamatergic neurotransmission, gene expression, postmortem brain
- MeSH terms
- Adult, Aged, Animals, Astrocytes, Female, Humans, Middle Aged, Schizophrenia, Xenopus, Prefrontal Cortex, Excitatory Amino Acid Transporter 2
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