Cited by 153Schizophrenia research and treatmentAdvanced MRI Techniques and ApplicationsNeurotransmitter Receptor Influence on Behavior

1H-MRS at 4 Tesla in minimally treated early schizophrenia

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Bustillo, J R, Rowland, L M, Mullins, P, Jung, R, Chen, H, Qualls, C, Hammond, R, Brooks, W M +1 more·2010·Molecular Psychiatry

Abstract

We investigated glutamate-related neuronal dysfunction in the anterior cingulate (AC) early in schizophrenia before and after antipsychotic treatment. A total of 14 minimally treated schizophrenia patients and 10 healthy subjects were studied with single-voxel proton magnetic resonance spectroscopy ((1)H-MRS) of the AC, frontal white matter and thalamus at 4 T. Concentrations of N-acetylaspartate (NAA), glutamate (Glu), glutamine (Gln) and Gln/Glu ratios were determined and corrected for the partial tissue volume. Patients were treated with antipsychotic medication following a specific algorithm and (1)H-MRS was repeated after 1, 6 and 12 months. There were group x region interactions for baseline NAA (P=0.074) and Gln/Glu (P=0.028): schizophrenia subjects had lower NAA (P=0.045) and higher Gln/Glu (P=0.006) in the AC before treatment. In addition, AC Gln/Glu was inversely related to AC NAA in the schizophrenia (P=0.0009) but not in the control group (P=0.92). Following antipsychotic treatment, there were no further changes in NAA, Gln/Glu or any of the other metabolites in any of the regions studied. We conclude that early in the illness, schizophrenia patients already show abnormalities in glutamatergic metabolism and reductions in NAA consistent with glutamate-related excitotoxicity.

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Authors
Bustillo, J. R., Rowland, L. M., Mullins, P., Jung, R., Chen, H., Qualls, C., Hammond, R., Brooks, W. M., & Lauriello, J.
Affiliations
  • University of New Mexico (US)
  • University of Maryland, Baltimore (US)
  • University of Kansas Medical Center (US)
Corresponding author
Bustillo, J R
Venue
Molecular Psychiatry
Published
2009-11-17
Volume
15
Issue
6
Pages
629-636
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
OpenAlex
W2057429979
Cited by
153
References
40
Citations by year
2026: 1 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 11 · 2020: 6 · 2019: 9 · 2018: 10 · 2017: 10 · 2016: 12 · 2015: 15 · 2014: 12 · 2013: 13 · 2012: 15
FWCI
6.99
Type
journal article
Language
en
Open access
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (R01MH084898)
  • National Institute of Neurological Disorders and Stroke (NS 039123, R01NS039123)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
schizophrenia, early schizophrenia, glutamate, glutamine, N-acetylaspartate, excitotoxicity, anterior cingulate cortex, antipsychotic drugs, frontal white matter, thalamus, brain metabolites
MeSH terms
Adult, Aspartic Acid, Female, Frontal Lobe, Glutamine, Gyrus Cinguli, Humans, Male, Nerve Fibers, Myelinated, Magnetic Resonance Spectroscopy, Protons, Schizophrenia, Thalamus, Time Factors, Antipsychotic Agents, Glutamic Acid

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