The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Cellular iron status influences the functional relationship between microglia and oligodendrocytes
Abstract
Previously, we have reported that there is a spatiotemporal relationship between iron accumulation in microglia and oligodendrocytes during normal development and in remyelination following injury. This in vivo observation has prompted us to develop a cell culture model to test the relationship between iron status of microglia and survival of oligodendrocytes. We found that conditioned media from iron‐loaded microglia increases the survival of oligodendrocytes; but conditioned media from iron loaded activated microglia is toxic to oligodendrocytes. In the trophic condition, one of the proteins released by iron‐loaded microglia is H‐ferritin, and transfecting the microglia with siRNA for H‐ferritin blocks the trophic response on oligodendrocytes. Lipopolysaccharide (LPS) activation decreases the amount of H‐ferritin that is released from microglia and increases the release of the proinflammatory cytokines tumor necrosis factor‐α and interleukin‐1. LPS activation of iron‐enriched microglia results in the activation of NF‐kB and greater release of cytokines when compared with that of control microglia; whereas treating microglia with an iron chelator is associated with less NF‐kB activation and less release of cytokines. These results indicate that microglia play an important role in iron homoeostasis and that their iron status can influence how microglia influence growth and survival of oligodendrocytes. The results further indicate that ferritin, released by microglia, is a significant source of iron for oligodendrocytes. © 2006 Wiley‐Liss, Inc.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cell death and control of cell survival in the oligodendrocyte lineage
Barres, B. A., Hart, I. K., Coles, H. S. R., Burne, J. F., Voyvodic, J. T., Richardson, W. D., & Raff, M. C. (1992) · Cell · doi:10.1016/0092-8674(92)90531-g · Cited by 1,345
Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains
Connor, J. R., Menzies, S. L., Martin, S. M. S., & Mufson, E. J. (1990) · Journal of Neuroscience Research · doi:10.1002/jnr.490270421 · Cited by 472
Self-citationBrain iron pathways and their relevance to Parkinson's disease
Berg, D., Gerlach, M., Youdim, M. B. H., Double, K. L., Zecca, L., Riederer, P., & Becker, G. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00608.x · Cited by 362
Pre- and postweaning iron deficiency alters myelination in Sprague-Dawley rats
Beard, J. L., Wiesinger, J. A., & Connor, J. R. (2003) · Developmental Neuroscience · doi:10.1159/000073507 · Cited by 200
Self-citationCozzi, A., Corsi, B., Levi, S., Santambrogio, P., Biasiotto, G., & Arosio, P. (2004) · Blood · doi:10.1182/blood-2003-06-1842 · Cited by 132 · cited 2×
“Generation and purification of the double-stranded small interfering RNAs (siRNAs) for H-ferritin used in this study has been described previously (Cozzi et al., 2004).”
MethodSelf-citationMacrophages in CNS remyelination: friend or foe?
Diemel, L. T., Copelman, C. A., & Cuzner, M. L. (1998) · Neurochemical Research · doi:10.1023/a:1022405516630 · Cited by 78
Desferrioxamine suppresses experimental allergic encephalomyelitis induced by MBP in SJL mice
Pedchenko, T. V., & LeVine, S. M. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00256-7 · Cited by 78
Visseren, F. L. J., Verkerk, M. S. A., Van Der Bruggen, T., Marx, J. J. M., Van Asbeck, B. S., & Diepersloot, R. J. A. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.0320s1084.x · Cited by 64
Cited by
Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics
Belaidi, A. A., & Bush, A. I. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13425 · Cited by 578
Iron and neurodegeneration in the multiple sclerosis brain
Hametner, S., Wimmer, I., Haider, L., Pfeifenbring, S., Brück, W., & Lassmann, H. (2013) · Annals of Neurology · doi:10.1002/ana.23974 · Cited by 519
Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration
Masaldan, S., Bush, A. I., Devos, D., Rolland, A. S., & Moreau, C. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.033 · Cited by 481
Metal Toxicity Links to Alzheimer's Disease and Neuroinflammation
Huat, T. J., Camats-Perna, J., Newcombe, E. A., Valmas, N., Kitazawa, M., & Medeiros, R. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.01.018 · Cited by 470
Oligodendrocyte, Astrocyte, and Microglia Crosstalk in Myelin Development, Damage, and Repair
Domingues, H. S., Portugal, C. C., Socodato, R., & Relvas, J. B. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00071 · Cited by 432
Metadata
- Authors
- Zhang, X., Surguladze, N., Slagle‐Webb, B., Cozzi, A., & Connor, J. R.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2006-09-06
- Volume
- 54
- Issue
- 8
- Pages
- 795-804
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W2049381107
- Cited by
- 160
- References
- 8
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cellular iron status influences the functional relationship between microglia and oligodendrocytes. https://app.cochat.ai/papers/10.1002/glia.20416
- The paper
- Zhang, X., Surguladze, N., Slagle‐Webb, B., Cozzi, A., & Connor, J. R. (2006). Cellular iron status influences the functional relationship between microglia and oligodendrocytes. Glia. https://doi.org/10.1002/glia.20416
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
