The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Astrocytes—Friends or foes in multiple sclerosis?
Abstract
In multiple sclerosis (MS), the presence of demyelinating plaques has concentrated researchers' minds on the role of the oligodendrocyte in its pathophysiology. Recently, with the rediscovery of early and widespread loss of axons in the disease, new emphasis has been put on the role of axons and axon‐oligodendrocyte interactions in MS. Despite the fact that, in 1904, Müller claimed that MS was a disease of astrocytes, more recently, astrocytes have taken a back seat, except as the cells that form the final glial scar after all hope of demyelination is over. However, perhaps it is time for the return of the astrocyte to popularity in the pathogenesis of MS, with recent reports on the dual role of astrocytes in aiding degeneration and demyelination, by promoting inflammation, damage of oligodendrocytes and axons, and glial scarring, but also in creating a permissive environment for remyelination by their action on oligodendrocyte precursor migration, oligodendrocyte proliferation, and differentiation. We review these findings to try to provide a cogent view of astrocytes in the pathology of MS. © 2007 Wiley‐Liss, Inc.
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Cites
B cells regulate autoimmunity by provision of IL-10
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TNFα promotes proliferation of oligodendrocyte progenitors and remyelination
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Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis
Greter, M., Heppner, F. L., Lemos, M. P., Odermatt, B. M., Goebels, N., Laufer, T., Noelle, R. J., & Becher, B. (2005) · Nature Medicine · doi:10.1038/nm1197 · Cited by 862
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“, 1993) and those with a disrupted IGF-1 gene have smaller brains, fewer oligodendrocytes, and less myelin content (Beck et al., 1995).”
BackgroundHyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation
Back, S. A., Tuohy, T. M. F., Chen, H., Wallingford, N., Craig, A., Struve, J., Luo, N. L., Banine, F., Liu, Y., Chang, A., et al. (2005) · Nature Medicine · doi:10.1038/nm1279 · Cited by 612
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Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes
Matute, C., Sánchez-Gómez, M. V., Martínez-Millán, L., & Miledi, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8830 · Cited by 352
Cited by
Remyelination in the CNS: from biology to therapy
Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544
Oligodendrocyte, Astrocyte, and Microglia Crosstalk in Myelin Development, Damage, and Repair
Domingues, H. S., Portugal, C. C., Socodato, R., & Relvas, J. B. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00071 · Cited by 432
Skripuletz, T., Hackstette, D., Bauer, K., Gudi, V., Pul, R., Voss, E., Berger, K., Kipp, M., Baumgärtner, W., & Stangel, M. (2013) · Brain · doi:10.1093/brain/aws262 · Cited by 376
Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned
Gudi, V., Gingele, S., Skripuletz, T., & Stangel, M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00073 · Cited by 375
“Astrocytes in MS are considered to possess a dual role since beneficial as well as detrimental effects of astrocytes on de- and remyelination are being discussed (Williams et al., 2007; Nair et al., 2008; Kipp et al., 2011a; Moore et al., 2011).”
BackgroundBuffo, A., Rolando, C., & Ceruti, S. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.09.014 · Cited by 321
Metadata
- Authors
- Williams, A., Piaton, G., & Lubetzki, C.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2007-07-30
- Volume
- 55
- Issue
- 13
- Pages
- 1300-1312
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W2084887202
- Cited by
- 302
- References
- 18
- FWCI
- 11.40
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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