B cells regulate autoimmunity by provision of IL-10
Abstract
To assess the importance of B cell control of T cell differentiation, we analyzed the course of the T helper type 1 (T(H)1)-driven disease experimental autoimmune encephalomyelitis in mice with an altered B cell compartment. We found that recovery was dependent on the presence of autoantigen-reactive B cells. B cells from recovered mice produced interleukin 10 (IL-10) in response to autoantigen. With a bone marrow chimeric system, we generated mice in which IL-10 deficiency was restricted to B cells but not T cells. In the absence of IL-10 production by B cells, the pro-inflammatory type 1 immune response persisted and mice did not recover. These data show that B cell-derived IL-10 plays a key role in controlling autoimmunity.
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Bregs are B cells with regulatory and immunosuppressive functions that maintain immunological homeostasis by producing IL-10, IL-35, and TGFβ, thereby suppressing immunopathology.
“Bregs is a generic term used to define B cells endowed with regulatory and immunosuppressive functions. They play a crucial role in maintain ing immunological homeostasis by producing anti-inflammatory cyto kines such as interleukin-10 (IL-10), IL-35, and transforming growth factor-beta (TGFβ ), thereby suppressing immunopathology.”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [54]
Mice genetically altered in B cell development, particularly those lacking IL-10-producing B cells, develop uncontrolled autoimmune diseases.
“Findings demonstrate that mice genetically altered in B cell development, partic ularly those lacking IL-10-producing B cells, develop uncontrolled auto immune diseases [53,54].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [54]
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Self-citation
- Authors
- Fillatreau, S., Sweenie, C. H., McGeachy, M. J., Gray, D., & Anderton, S. M.
- Affiliations
- University of Edinburgh (GB)
- Corresponding author
- Anderton, Stephen M.
- Venue
- Nature Immunology
- Published
- 2002-09-03
- Volume
- 3
- Issue
- 10
- Pages
- 944-950
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2077297620
- Cited by
- 1,647
- References
- 1
- Citations by year
- 2026: 37 · 2025: 45 · 2024: 70 · 2023: 54 · 2022: 70 · 2021: 94 · 2020: 79 · 2019: 84 · 2018: 78 · 2017: 86 · 2016: 99 · 2015: 115 · 2014: 119 · 2013: 91 · 2012: 90
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- B cells, IL-10, autoimmunity, experimental autoimmune encephalomyelitis, T cell differentiation, bone marrow chimerism, recovery from illness, pro-inflammatory response
- MeSH terms
- Animals, B-Lymphocytes, Encephalomyelitis, Autoimmune, Experimental, Mice, Inbred C57BL, Autoimmunity, Interleukin-10, Mice, Knockout, Th1 Cells, Mice
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