The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy: Reduced KCC2 Underlie Tumor-Related Epilepsy
Open accessAbstract
Seizures frequently accompany gliomas and often escalate to peritumoral epilepsy. Previous work revealed the importance of tumor-derived excitatory glutamate (Glu) release mediated by the cystine-glutamate transporter (SXC) in epileptogenesis. We now show a novel contribution of GABAergic disinhibition to disease pathophysiology. In a validated mouse glioma model, we found that peritumoral parvalbumin-positive GABAergic inhibitory interneurons are significantly reduced, corresponding with deficits in spontaneous and evoked inhibitory neurotransmission. Most remaining peritumoral neurons exhibit elevated intracellular Cl(-) concentration ([Cl(-) ]i ) and consequently depolarizing, excitatory gamma-aminobutyric acid (GABA) responses. In these neurons, the plasmalemmal expression of KCC2, which establishes the low [Cl(-) ]i required for GABAA R-mediated inhibition, is significantly decreased. Interestingly, reductions in inhibition are independent of Glu release, but the presence of both decreased inhibition and decreased SXC expression is required for epileptogenesis. We suggest GABAergic disinhibition renders peritumoral neuronal networks hyper-excitable and susceptible to seizures triggered by excitatory stimuli, and propose KCC2 as a therapeutic target.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The cellular and molecular changes underlying tumor-associated epilepsy collectively point to a decrease in GABAergic and increase in glutamatergic transmission as the major contributors3–6.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [3]
In the citing paper
“the peritumoral brain shows ~35% reduction in the density of fast spiking GABAergic interneurons3”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [3]
In the citing paper
“the remaining GABAergic neurons show a significantly reduced inhibitory potential.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [3]
In the citing paper
“Glu release, while necessary, is insufficient to drive peritumoral epilepsy3. Rather an additional loss of GABAergic inhibition is required”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [3]
In the citing paper
“Seizures originate from the PTC, and previous studies3,5,6 show altered excitation−inhibition balance in the PTC due to changes in glutamatergic and GABAergic activity.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [3]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
Excitatory actions of gaba during development: the nature of the nurture
Ben-Ari, Y. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn920 · Cited by 2,448
Glioblastoma and Other Malignant Gliomas
Omuro, A. M. P. (2013) · JAMA · doi:10.1001/jama.2013.280319 · Cited by 2,308
The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
Rivera, C., Voipio, J., Payne, J. A., Ruusuvuori, E., Lahtinen, H., Lamsa, K., Pirvola, U., Saarma, M., & Kaila, K. (1999) · Nature · doi:10.1038/16697 · Cited by 2,152
Incidence of Epilepsy and Unprovoked Seizures in Rochester, Minnesota: 1935–1984
Hauser, W. A., Annegers, J. F., & Kurland, L. T. (1993) · Epilepsia · doi:10.1111/j.1528-1157.1993.tb02586.x · Cited by 2,084
GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
Ben-Ari, Y., Gaiarsa, J.-L., Tyzio, R., & Khazipov, R. (2007) · Physiological Reviews · doi:10.1152/physrev.00017.2006 · Cited by 1,304
GABA: an excitatory transmitter in early postnatal life
Cherubini, E., Gaïarsa, J., & Ben‐Ari, Y. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90003-d · Cited by 1,108
On the Origin of Interictal Activity in Human Temporal Lobe Epilepsy in Vitro
Cohen, I., Navarro, V., Clémenceau, S., Baulac, M., & Miles, R. (2002) · Science · doi:10.1126/science.1076510 · Cited by 1,001
The GABA Excitatory/Inhibitory Shift in Brain Maturation and Neurological Disorders
Ben‐Ari, Y., Khalilov, I., Kahle, K. T., & Cherubini, E. (2012) · The Neuroscientist · doi:10.1177/1073858412438697 · Cited by 650
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Electrical and synaptic integration of glioma into neural circuits
Venkatesh, H. S., Morishita, W., Geraghty, A. C., Silverbush, D., Gillespie, S. M., Arzt, M., Tam, L. T., Espenel, C., Ponnuswami, A., Ni, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1563-y · Cited by 1,366
Cancer neuroscience: State of the field, emerging directions
Winkler, F., Venkatesh, H. S., Amit, M., Batchelor, T. T., Demir, İ. E., Deneen, B., Gutmann, D. H., Hervey‐Jumper, S. L., Kuner, T., Mabbott, D., et al. (2023) · Cell · doi:10.1016/j.cell.2023.02.002 · Cited by 602
Identification of diverse astrocyte populations and their malignant analogs
John Lin, C.-C., Yu, K., Hatcher, A., Huang, T.-W., Lee, H. K., Carlson, J., Weston, M. C., Chen, F., Zhang, Y., Zhu, W., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4493 · Cited by 525
Neuron–glia interactions in the pathophysiology of epilepsy
Patel, D. C., Tewari, B. P., Chaunsali, L., & Sontheimer, H. W. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0126-4 · Cited by 478
Self-citationGlioblastoma remodelling of human neural circuits decreases survival
Krishna, S., Choudhury, A., Keough, M. B., Seo, K., Ni, L., Kakaizada, S., Lee, A. J., Aabedi, A. A., Popova, G., Lipkin, B., et al. (2023) · Nature · doi:10.1038/s41586-023-06036-1 · Cited by 466
Mancusi, R. A., & Monje, M. (2023) · Nature · doi:10.1038/s41586-023-05968-y · Cited by 388
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer
Petralia, F., Tignor, N., Reva, B., Koptyra, M., Chowdhury, S., Rykunov, D., Krek, A., Ma, W., Zhu, Y., Ji, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.044 · Cited by 317
Revisiting the role of neurotransmitters in epilepsy: An updated review
Akyüz, E., Polat, A. K., Eroğlu, E., Küllü, İ., Angelopoulou, E., & Paudel, Y. N. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118826 · Cited by 314
Reactive Astrogliosis Causes the Development of Spontaneous Seizures
Robel, S., Buckingham, S. C., Boni, J. L., Campbell, S. L., Danbolt, N. C., Riedemann, T., Sutor, B., & Sontheimer, H. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1574-14.2015 · Cited by 283
Self-citationPIK3CA variants selectively initiate brain hyperactivity during gliomagenesis
Yu, K., Lin, C.-C. J., Hatcher, A., Lozzi, B., Kong, K., Huang-Hobbs, E., Cheng, Y.-T., Beechar, V. B., Zhu, W., Zhang, Y., et al. (2020) · Nature · doi:10.1038/s41586-020-1952-2 · Cited by 255
WNK Kinase Signaling in Ion Homeostasis and Human Disease
Shekarabi, M., Zhang, J., Khanna, A. R., Ellison, D. H., Delpire, E. J., & Kahle, K. T. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.01.007 · Cited by 247
Self-citationTewari, B. P., Chaunsali, L., Campbell, S. L., Patel, D. C., Goode, A. E., & Sontheimer, H. (2018) · Nature Communications · doi:10.1038/s41467-018-07113-0 · Cited by 208
Self-citationSeizures and gliomas — towards a single therapeutic approach
Huberfeld, G., & Vecht, C. J. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.26 · Cited by 206
Glia as drivers of abnormal neuronal activity
Robel, S., & Sontheimer, H. W. (2015) · Nature Neuroscience · doi:10.1038/nn.4184 · Cited by 198
Self-citationGABAergic neuron-to-glioma synapses in diffuse midline gliomas
Barron, T., Yalçın, B., Su, M., Byun, Y. G., Gavish, A., Shamardani, K., Xu, H., Ni, L., Soni, N., Mehta, V., et al. (2025) · Nature · doi:10.1038/s41586-024-08579-3 · Cited by 187
Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities
Shi, D. D., Guo, J. A., Hoffman, H. I., Su, J., Mino-Kenudson, M. A., Barth, J. L., Schenkel, J. M., Loeffler, J. S., Shih, H. A., Hong, T. S., et al. (2022) · The Lancet Oncology · doi:10.1016/s1470-2045(21)00596-9 · Cited by 151
Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing
Tetzlaff, S. K., Reyhan, E., Layer, N., Bengtson, C. P., Heuer, A., Schroers, J., Faymonville, A. J., Langeroudi, A. P., Drewa, N., Keifert, E., et al. (2024) · Cell · doi:10.1016/j.cell.2024.11.002 · Cited by 155
Seizing Control of KCC2: A New Therapeutic Target for Epilepsy
Moore, Y. E., Kelley, M. R., Brandon, N. J., Deeb, T. Z., & Moss, S. J. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.06.008 · Cited by 147
Emerging intersections between neuroscience and glioma biology
Jung, E., Alfonso, J., Osswald, M., Monyer, H., Wick, W., & Winkler, F. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0540-y · Cited by 146
Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures
Moore, Y. E., Deeb, T. Z., Chadchankar, H., Brandon, N. J., & Moss, S. J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1810134115 · Cited by 126
A prognostic neural epigenetic signature in high-grade glioma
Drexler, R., Khatri, R., Sauvigny, T., Mohme, M., Maire, C. L., Ryba, A. S., Zghaibeh, Y., Dührsen, L., Salviano‐Silva, A., Lamszus, K., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-02969-w · Cited by 141
Tumor-related epilepsy: epidemiology, pathogenesis and management
Chen, D. Y., Chen, C. C., Crawford, J. R., & Wang, S. G. (2018) · Journal of Neuro-Oncology · doi:10.1007/s11060-018-2862-0 · Cited by 116
GABA ergic signalling in the immune system
Barragán, A., Weidner, J. M., Jin, Z., Korpi, E. R., & Birnir, B. (2015) · Acta Physiologica · doi:10.1111/apha.12467 · Cited by 110
Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model
Hatcher, A., Yu, K., Meyer, J. F., Aiba, I., Deneen, B., & Noebels, J. L. (2020) · Journal of Clinical Investigation · doi:10.1172/jci133316 · Cited by 114
Montgomery, M. K., Kim, S. H., Dovas, A., Zhao, H., Goldberg, A., Xu, W., Yagielski, A. J., Cambareri, M. K., Patel, K., Mela, A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.064 · Cited by 108
Neuron–oligodendroglial interactions in health and malignant disease
Taylor, K. R., & Monje, M. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00744-3 · Cited by 106
Interactions between Tumor Cells, Neurons, and Microglia in the Glioma Microenvironment
Radin, D. P., & Tsirka, S. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228476 · Cited by 101
van Hugte, E., Schubert, D., & Kasri, N. N. (2023) · Epilepsia · doi:10.1111/epi.17651 · Cited by 100
Anastasaki, C., Mo, J., Chen, J., Chatterjee, J., Pan, Y., Scheaffer, S. M., Cobb, O. M., Monje, M., Le, L. Q., & Gutmann, D. H. (2022) · Nature Communications · doi:10.1038/s41467-022-30466-6 · Cited by 98
KCC2 downregulation facilitates epileptic seizures
Chen, L., Wan, L., Wu, Z., Ren, W., Huang, Y., Qian, B., & Wang, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-00196-7 · Cited by 86
Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation
Curry, R. N., Aiba, I., Meyer, J. F., Lozzi, B., Ko, Y., McDonald, M. F., Rosenbaum, A., Cervantes, A., Huang-Hobbs, E., Cocito, C., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.01.013 · Cited by 88
Neuronal K+-Cl- cotransporter KCC2 as a promising drug target for epilepsy treatment
McMoneagle, E., Zhou, J. Q., Zhang, S., Huang, W., Josiah, S. S., Ding, K., Wang, Y., & Zhang, J. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01149-9 · Cited by 78
Diffuse Low-Grade Glioma-Related Epilepsy
Pallud, J., & McKhann, G. M. (2018) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2018.09.001 · Cited by 74
Roles of glial ion transporters in brain diseases
Song, S., Luo, L., Sun, B., & Sun, D. (2019) · Glia · doi:10.1002/glia.23699 · Cited by 76
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling
Drexler, R., Drinnenberg, A., Gavish, A., Yalçın, B., Shamardani, K., Rogers, A. E., Mancusi, R. A., Trivedi, V., Taylor, K. R., Kim, Y. S., et al. (2025) · Cell · doi:10.1016/j.cell.2025.05.031 · Cited by 82
Compromised GABAergic inhibition contributes to tumor-associated epilepsy
MacKenzie, G., O’Toole, K. K., Moss, S. J., & Maguire, J. L. (2016) · Epilepsy Research · doi:10.1016/j.eplepsyres.2016.07.010 · Cited by 72
The KCC2 Cotransporter and Human Epilepsy
Kahle, K. T., Khanna, A. R., Duan, J., Staley, K. J., Delpire, E. J., & Poduri, A. (2016) · The Neuroscientist · doi:10.1177/1073858416645087 · Cited by 69
Self-citationJung, E., Alfonso, J., Monyer, H., Wick, W., & Winkler, F. (2020) · International Journal of Cancer · doi:10.1002/ijc.33138 · Cited by 70
Seizures in glioma patients: An overview of incidence, etiology, and therapies
Samudra, N. P., Zacharias, T., Plitt, A. R., Lega, B. C., & Pan, E. (2019) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2019.07.026 · Cited by 59
Glioma-neuronal circuit remodeling induces regional immunosuppression
Nejo, T., Krishna, S., Yamamichi, A., Lakshmanachetty, S., Jimenez, C., Lee, K. Y., Baker, D. L., Young, J. S., Chen, T., Phyu, S. M., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60074-z · Cited by 72
Ye, H., & Kaszuba, S. V. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0399-8 · Cited by 63
Tantillo, E., Vannini, E., Cerri, C., Spalletti, C., Colistra, A., Mazzanti, C. M., Costa, M., & Caleo, M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104942 · Cited by 60
Kang, S. K., Markowitz, G. J., Kim, S. T., Johnston, M. V., & Kadam, S. D. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00173 · Cited by 52
Berntsson, S. G., Merrell, R. T., Amirian, E. S., Armstrong, G., Lachance, D. H., Smits, A., Zhou, R., Jacobs, D. I., Wrensch, M., Olson, S. H., et al. (2018) · Journal of Neurology · doi:10.1007/s00415-018-8857-0 · Cited by 53
When Are Depolarizing GABAergic Responses Excitatory?
Kilb, W. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.747835 · Cited by 49
Potassium and glutamate transport is impaired in scar-forming tumor-associated astrocytes
Campbell, S. C., Muñoz‐Ballester, C., Chaunsali, L., Mills, W. A., Yang, J. H., Sontheimer, H. W., & Robel, S. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104628 · Cited by 50
Self-citationKeough, M. B., & Monje, M. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-111020-092702 · Cited by 47
Double-edged GABAergic synaptic transmission in seizures: The importance of chloride plasticity
Wang, Y., Wang, Y., & Chen, Z. (2018) · Brain Research · doi:10.1016/j.brainres.2018.09.008 · Cited by 47
Multi‐omics technologies and molecular biomarkers in brain tumor‐related epilepsy
Du, Y., Li, R., Fu, D., Zhang, B., Cui, A., Shao, Y., Lai, Z., Chen, R., Chen, B., Wang, Z., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14717 · Cited by 45
Glioblastoma disrupts cortical network activity at multiple spatial and temporal scales
Meyer, J. F., Yu, K., Luna-Figueroa, E., Deneen, B., & Noebels, J. L. (2024) · Nature Communications · doi:10.1038/s41467-024-48757-5 · Cited by 47
Expanding Spectrum of Sodium Potassium Chloride Co-transporters in the Pathophysiology of Diseases
Jaggi, A. S., Kaur, A., Bali, A., & Singh, N. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150205130359 · Cited by 45
Neuron–Glial Interactions in Health and Brain Cancer
Pan, Y., & Monje, M. (2022) · Advanced Biology · doi:10.1002/adbi.202200122 · Cited by 46
Düsterwald, K. M., Currin, C. B., Burman, R. J., Akerman, C. J., Kay, A. R., & Raimondo, J. V. (2018) · eLife · doi:10.7554/elife.39575 · Cited by 45
What is New in the Management of Epilepsy in Gliomas?
Rudà, R., & Soffietti, R. (2015) · Current Treatment Options in Neurology · doi:10.1007/s11940-015-0351-8 · Cited by 43
Role of Astrocytes in Post-traumatic Epilepsy
Xu, S., Sun, Q., Fan, J., Jiang, Y., Yang, W., Cui, Y., Yu, Z., Jiang, H., & Li, B. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01149 · Cited by 44
Sánchez-Aguilera, A., Masmudi‐Martín, M., Navas-Olivé, A., Baena, P., Hernández-Oliver, C., Priego, N., Cordón-Barris, L., Álvaro‐Espinosa, L., García‐Martín, S., Martínez, S., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.07.010 · Cited by 42
Cardona, A. F., Rojas, L., Wills, B., Bernal, L., Ruíz-Patiño, A., Arrieta, O. G., Hakim, E. J., Hakim, F., Mejía, J. A., Useche, N., et al. (2017) · Journal of Neuro-Oncology · doi:10.1007/s11060-017-2660-0 · Cited by 40
Stone, T. J., Rowell, R., Jayasekera, B. A. P., Cunningham, M. O., & Jacques, T. S. (2018) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12459 · Cited by 40
Synaptic Communication in Brain Cancer
Monje, M. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-0646 · Cited by 44
Ion Channels and Their Role in the Pathophysiology of Gliomas
Takayasu, T., Kurisu, K., Esquenazi, Y., & Ballester, L. Y. (2020) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-19-0929 · Cited by 40
Converging Mechanisms of Epileptogenesis and Their Insight in Glioblastoma
Hills, K., Kostarelos, K., & Wykes, R. C. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.903115 · Cited by 44
Crosstalk between cancer cells and the nervous system
Huang, M., Gong, G., Deng, Y., Long, X., Long, W., Liu, Q., Zhao, W., & Chen, R. (2023) · Medicine Advances · doi:10.1002/med4.27 · Cited by 41
Robinson, S., Winer, J. L., Berkner, J., Chan, L. A. S., Denson, J. L., Maxwell, J. R., Yang, Y., Sillerud, L. O., Tasker, R. C., Meehan, W. P., III, et al. (2016) · Journal of Neurosurgery Pediatrics · doi:10.3171/2015.10.peds15554 · Cited by 38
Goldstein, E. D., & Feyissa, A. M. (2018) · Neurologia i Neurochirurgia Polska · doi:10.1016/j.pjnns.2018.06.001 · Cited by 40
The neuroscience of brain cancers
Monje, M. (2025) · Neuron · doi:10.1016/j.neuron.2025.07.012 · Cited by 43
Jantzie, L. L., Getsy, P. M., Denson, J. L., Firl, D. J., Maxwell, J. R., Rogers, D. A., Wilson, C. G., & Robinson, S. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00347 · Cited by 35
Old Stars and New Players in the Brain Tumor Microenvironment
Parmigiani, E., Scalera, M., Mori, E., Tantillo, E., & Vannini, E. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.709917 · Cited by 34
Glioma-Induced Alterations in Excitatory Neurons are Reversed by mTOR Inhibition
Goldberg, A. R., Dovas, A., Torres, D., Pereira, B., Viswanathan, A., Sharma, S. D., Mela, A., Merricks, E. M., Megino‐Luque, C., McInvale, J. J., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.12.026 · Cited by 36
Ion Channels in Gliomas—From Molecular Basis to Treatment
Elias, A. F., Lin, B. C., & Piggott, B. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032530 · Cited by 33
Vannini, E., Olimpico, F., Middei, S., Ammassari‐Teule, M., de Graaf, E. L., McDonnell, L. A., Schmidt, G., Fabbri, A., Fiorentini, C., Baroncelli, L., et al. (2016) · Neuro-Oncology · doi:10.1093/neuonc/now114 · Cited by 30
Mechanisms and therapeutic implications of glioma-neuron interactions
Wang, Y., Wang, Y., Bao, H., Wang, Z., & Jiang, T. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217884 · Cited by 32
Peritumoural glutamate correlates with post-operative seizures in supratentorial gliomas
Neal, A. J., Yuen, T., Bjorksten, A. R., Kwan, P., O'Brien, T. J., & Morokoff, A. P. (2016) · Journal of Neuro-Oncology · doi:10.1007/s11060-016-2169-y · Cited by 28
Venkataramani, V., Yang, Y., Ille, S., Suchorska, B., Loges, S., Tost, H., Sahm, F., Pfister, S. M., Trumpp, A., Krieg, S. M., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0194 · Cited by 33
Cancer neuroscience: signaling pathways and new therapeutic strategies for cancer
Zhang, S., Yuan, L., Lin, P., Yang, G., Zhou, X., Jinfu, X., Wu, M., & Huang, Y. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02364-y · Cited by 29
In vitro ictogenesis is stochastic at the single neuron level
Lau, L. A., Staley, K. J., & Lillis, K. P. (2021) · Brain · doi:10.1093/brain/awab312 · Cited by 25
Gill, B. J. A., Khan, F. A., Goldberg, A., Merricks, E. M., Wu, X., Sosunov, A. A., Sudhakar, T. D., Dovas, A., Lado, W. E., Michalak, A. J., et al. (2022) · Brain · doi:10.1093/brain/awac168 · Cited by 27
Neurons as stromal drivers of nervous system cancer formation and progression
Anastasaki, C., Gao, Y., & Gutmann, D. H. (2023) · Developmental Cell · doi:10.1016/j.devcel.2022.12.011 · Cited by 26
Li, X., & Hong, M. (2019) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12139 · Cited by 25
Advancing glioblastoma therapy: Learning from the past and innovations for the future
Rana, M., Liou, K.-C., Thakur, A., Nepali, K., & Liou, J. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217601 · Cited by 28
The role of SLC12A family of cation-chloride cotransporters and drug discovery methodologies
Zhang, S., Azlan, N. F. M., Josiah, S. S., Zhou, J., Xiaoxia, Z., Jie, L., Zhang, Y., Dai, C., Liang, D., Li, P., et al. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.09.002 · Cited by 29
Lia, A., Spiezio, A. D., Vitalini, L., Tore, M., Puja, G., & Losi, G. (2023) · Life · doi:10.3390/life13102038 · Cited by 32
Epilepsy in gliomas: recent insights into risk factors and molecular pathways
Rudà, R., Bruno, F., & Pellerino, A. (2023) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001214 · Cited by 24
New strategies for managing adult gliomas
Kirby, A. J., & Finnerty, G. T. (2020) · Journal of Neurology · doi:10.1007/s00415-020-09884-3 · Cited by 23
Muñoz‐Ballester, C., Mahmutovic, D., Rafiqzad, Y., Korot, A., & Robel, S. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.821885 · Cited by 26
Self-citationStella, M., Baiardi, G., Pasquariello, S., Sacco, F., Dellacasagrande, I., Corsaro, A., Mattioli, F., & Barbieri, F. (2023) · Biomedicines · doi:10.3390/biomedicines11020582 · Cited by 23
Picart, T., & Hervey‐Jumper, S. L. (2024) · Journal of Neuro-Oncology · doi:10.1007/s11060-024-04719-x · Cited by 20
Clasadonte, J., Morel, L., Barrios-Camacho, C. M., Chiang, M. S. R., Zhang, J., Iyer, L. K., Haydon, P. G., & Yang, Y. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.03.024 · Cited by 20
Animal models and human tissue compared to better understand and treat the epilepsies
Milior, G., Morin‐Brureau, M., Pallud, J., Miles, R., & Huberfeld, G. (2023) · Epilepsia · doi:10.1111/epi.17552 · Cited by 20
Glioblastoma remodeling of neural circuits in the human brain decreases survivalPreprint
Krishna, S., Choudhury, A., Seo, K., Ni, L., Kakaizada, S., Lee, A. J., Aabedi, A. A., Cao, C., Sudharshan, R., Egladyous, A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.18.431915 · Cited by 19
Microenvironmental Drivers of Glioma Progression
Jang, H. J., & Park, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052108 · Cited by 19
Gill, B. J. A., Wu, X., Khan, F. A., Sosunov, A. A., Liou, J.-Y., Dovas, A., Eissa, T. L., Banu, M. A., Bateman, L. M., McKhann, G. M., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104676 · Cited by 18
Beta-Amyloid (Aβ1-42) Increases the Expression of NKCC1 in the Mouse Hippocampus
Lam, P., Vinnakota, C., Guzmán, B. C., Newland, J., Peppercorn, K., Tate, W. P., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2022) · Molecules · doi:10.3390/molecules27082440 · Cited by 17
Glioma facilitates the epileptic and tumor-suppressive gene expressions in the surrounding region
Komiyama, K., Iijima, K., Kawabata‐Iwakawa, R., Fujihara, K., Kakizaki, T., Yanagawa, Y., Yoshimoto, Y., & Miyata, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-10753-4 · Cited by 18
Neurotransmitter power plays: the synaptic communication nexus shaping brain cancer
Mondal, J., & Huse, J. T. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02009-9 · Cited by 19
The complex molecular epileptogenesis landscape of glioblastoma
Soeung, V., Puchalski, R. B., & Noebels, J. L. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101691 · Cited by 19
The Neural Regulation of Cancer
Gillespie, S. M., & Monje, M. (2019) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030419-033349 · Cited by 21
Reprogramming neural‑tumor crosstalk: emerging therapeutic dimensions and targeting strategies
Liu, Q., Dong, Z.-K., Wang, Y., & Jin, W. (2025) · Military Medical Research · doi:10.1186/s40779-025-00661-9 · Cited by 20
SLC12A5 as a novel potential biomarker of glioblastoma multiforme
Chen, J., Handong, W., Deng, C., & Fei, M. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08371-y · Cited by 16
Progress in cancer neuroscience
Lan, Y., Zou, S., Wang, W., Chen, Q., & Zhu, Y. (2023) · MedComm · doi:10.1002/mco2.431 · Cited by 20
Altered Extracellular Matrix as an Alternative Risk Factor for Epileptogenicity in Brain Tumors
de Jong, J. M., Broekaart, D. W. M., Bongaarts, A., Mühlebner, A., Mills, J. D., van Vliet, E. A., & Aronica, E. (2022) · Biomedicines · doi:10.3390/biomedicines10102475 · Cited by 15
Metadata
- Authors
- Campbell, S. L., Robel, S., Cuddapah, V. A., Robert, S., Buckingham, S. C., Kahle, K. T., & Sontheimer, H.
- Affiliations
- University of Alabama at Birmingham (US)
- Boston Children's Hospital (US)
- Corresponding author
- Sontheimer, Harald
- ORCID
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2014-07-26
- Volume
- 63
- Issue
- 1
- Pages
- 23-36
- ISSN
- 0894-1491 (ISSN-L)
- PMC
- PMC4237714
- OpenAlex
- W1562543772
- Cited by
- 185
- References
- 53
- Citations by year
- 2026: 21 · 2025: 32 · 2024: 18 · 2023: 28 · 2022: 14 · 2021: 6 · 2020: 16 · 2019: 12 · 2018: 10 · 2017: 9 · 2016: 11 · 2015: 8
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Glia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5R01-NS036692, 2R01-NS052634, 5T32NS048039-03)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Keywords
- tumor-associated epilepsy, glioma, GABAergic disinhibition, parvalbumin interneurons, intracellular chloride, GABAergic inhibition, SLC7A11, glutamate release, epileptogenesis, GABAA receptor, therapeutic target
- MeSH terms
- K Cl- Cotransporters, Animals, Brain Neoplasms, Epilepsy, Female, gamma-Aminobutyric Acid, Glioma, Interneurons, Male, Synaptic Transmission, Neurons, Receptors, GABA-A, Symporters, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
