Cortical GABAergic excitation contributes to epileptic activities around human glioma
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Epileptic discharges in the neocortex surrounding human gliomas are initiated by GABAergic interneurons through alterations of chloride homeostasis in pyramidal cells.
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The cellular and molecular changes underlying tumor-associated epilepsy collectively point to a decrease in GABAergic and increase in glutamatergic transmission as the major contributors.
“The cellular and molecular changes underlying tumor-associated epilepsy collectively point to a decrease in GABAergic and increase in glutamatergic transmission as the major contributors3–6.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [5]
The remaining GABAergic neurons in peritumoral brain show a significantly reduced inhibitory potential.
“the remaining GABAergic neurons show a significantly reduced inhibitory potential.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [5]
Seizures originate from the PTC, and previous studies show altered excitation−inhibition balance in the PTC due to changes in glutamatergic and GABAergic activity.
“Seizures originate from the PTC, and previous studies3,5,6 show altered excitation−inhibition balance in the PTC due to changes in glutamatergic and GABAergic activity.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [5]
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RetractedThe 2007 WHO Classification of Tumours of the Central Nervous System
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Erratum to: The 2007 WHO classification of tumours of the central nervous system
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- Authors
- Pallud, J., Le Van Quyen, M., Bielle, F., Pellegrino, C., Varlet, P., Labussiere, M., Cresto, N., Dieme, M.-J., Baulac, M., Duyckaerts, C., Kourdougli, N., Chazal, G., Devaux, B., Rivera, C., Miles, R., Capelle, L., & Huberfeld, G.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Sorbonne Universités, University Pierre and Marie Curie (UPMC) University of Paris 06, F-75005 Paris, France.
- Sorbonne Université (FR)
- Inserm (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- University of Helsinki (FI)
- Corresponding author
- Bielle, Franck
- Pellegrino, Christophe
- Huberfeld, Gilles
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2014-07-09
- Volume
- 6
- Issue
- 244
- Pages
- 244ra89-244ra89
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4409113
- OpenAlex
- W2157338202
- Cited by
- 300
- References
- 64
- Citations by year
- 2026: 15 · 2025: 24 · 2024: 32 · 2023: 35 · 2022: 34 · 2021: 25 · 2020: 18 · 2019: 28 · 2018: 26 · 2017: 22 · 2016: 23 · 2015: 14 · 2014: 4
- FWCI
- 16.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- glioma, epileptogenicity, chloride homeostasis, KCC2, NKCC1, interictal epileptiform discharges, pyramidal neurons, interneurons, excitatory-inhibitory imbalance
- MeSH terms
- Action Potentials, Brain Neoplasms, Chlorides, Epilepsy, gamma-Aminobutyric Acid, Glioma, Glutamates, Humans, Interneurons, Neocortex
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