The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Microglia–Neuron Communication in Epilepsy
Open accessAbstract
Epilepsy has remained a significant social concern and financial burden globally. Current therapeutic strategies are based primarily on neurocentric mechanisms that have not proven successful in at least a third of patients, raising the need for novel alternative and complementary approaches. Recent evidence implicates glial cells and neuroinflammation in the pathogenesis of epilepsy with the promise of targeting these cells to complement existing strategies. Specifically, microglial involvement, as a major inflammatory cell in the epileptic brain, has been poorly studied. In this review, we highlight microglial reaction to experimental seizures, discuss microglial control of neuronal activities, and propose the functions of microglia during acute epileptic phenotypes, delayed neurodegeneration, and aberrant neurogenesis. Future research that would help fill in the current gaps in our knowledge includes epilepsy‐induced alterations in basic microglial functions, neuro–microglial interactions during chronic epilepsy, and microglial contribution to developmental seizures. Studying the role of microglia in epilepsy could inform therapies to better alleviate the disease. GLIA 2016;65:5–18
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Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
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Self-citationMicroglia-neuron crosstalk: Signaling mechanism and control of synaptic transmission
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Self-citationMicroglia and Neuroinflammation: What Place for P2RY12?
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Metadata
- Authors
- Eyo, U. B., Murugan, M., & Wu, L.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2016-05-18
- Volume
- 65
- Issue
- 1
- Pages
- 5-18
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W2401782172
- Cited by
- 296
- References
- 43
- FWCI
- 16.56
- Type
- journal article
- Language
- en
- Open access
- green
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