Microglia and Neuroinflammation: What Place for P2RY12?
Open accessAbstract
Microglia are immune brain cells involved in neuroinflammation. They express a lot of proteins on their surface such as receptors that can be activated by mediators released in the microglial environment. Among these receptors, purinergic receptor expression could be modified depending on the activation status of microglia. In this review, we focus on P2Y receptors and more specifically on P2RY12 that is involved in microglial motility and migration, the first step of neuroinflammation process. We describe the purinergic receptor families, P2RY12 structure, expression and physiological functions. The pharmacological and genetic tools for studying this receptor are detailed thereafter. Last but not least, we report the contribution of microglial P2RY12 to neuroinflammation in acute and chronic brain pathologies in order to better understand P2RY12 microglial role.
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M7 shows high expression of activation marker Tyrobp.
“whereas M7 shows high expression of activation marker Tyrobp. 36 , 37 , 38”
From Loss of <i>Inpp5d</i> has disease‐relevant and sex‐specific effects on glial transcriptomes (2024) · cites this paper as [37]
Section 2.4 discusses P2RY12 as a marker of healthy microglia and its decrease during activation; section 4 discusses microglial activation states. Neither addresses an M7 population or Tyrobp expression. Searches for “M7 Tyrobp” and “Tyrobp activation marker microglial cluster M7” found no passage supporting the claim; page numbers were not available in our copy. (LLM, conf=0.73)
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Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875 · see citing works
Microglia Function in the Central Nervous System During Health and Neurodegeneration
Colonna, M., & Butovsky, O. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052358 · Cited by 2,894 · see citing works
Identification of a unique TGF-β–dependent molecular and functional signature in microglia
Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,543 · see citing works
Burnstock, G. (1972) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06930-3 · Cited by 1,852 · see citing works
Neuroinflammation: The Devil Is in the Details
DiSabato, D. J., Quan, N., & Godbout, J. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13607 · Cited by 1,640 · see citing works
A polarizing question: do M1 and M2 microglia exist?
Ransohoff, R. M. (2016) · Nature Neuroscience · doi:10.1038/nn.4338 · Cited by 1,573 · see citing works
The P2Y12 receptor regulates microglial activation by extracellular nucleotides
Haynes, S. E., Hollopeter, G., Yang, G., Kurpius, D., Dailey, M. E., Gan, W.-B., & Julius, D. (2006) · Nature Neuroscience · doi:10.1038/nn1805 · Cited by 1,542 · see citing works
Microglia in physiology and disease
Wolf, S. A., Boddeke, H. W. G. M., & Kettenmann, H. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034406 · Cited by 1,426 · see citing works
Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain
Colton, C. A. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9164-4 · Cited by 871 · see citing works
Inflammasomes in neuroinflammatory and neurodegenerative diseases
Voet, S., Srinivasan, S., Lamkanfi, M., & van Loo, G. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201810248 · Cited by 761 · see citing works
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes
Galatro, T. F., Holtman, I. R., Lerario, A. M., Vainchtein, I. D., Brouwer, N., Sola, P. R., Veras, M. M., Pereira, T. F., Leite, R. E. P., Möller, T., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4597 · Cited by 741 · see citing works
A basis for distinguishing two types of purinergic receptor
Burnstock, G. (1978) · Medical Entomology and Zoology · Cited by 723 · see citing works
Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis
Zrzavy, T., Hametner, S., Wimmer, I., Butovsky, O., Weiner, H. L., & Lassmann, H. (2017) · Brain · doi:10.1093/brain/awx113 · Cited by 684 · see citing works
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions
Cserép, C., Pósfai, B., Lénárt, N., Fekete, R., László, Z. I., Lele, Z., Orsolits, B., Molnár, G., Heindl, S., Schwarcz, A. D., et al. (2020) · Science · doi:10.1126/science.aax6752 · Cited by 684 · see citing works
Jay, T. R., Miller, C. M., Cheng, P. J., Graham, L. C., Bemiller, S., Broihier, M. L., Xu, G., Margevicius, D., Karlo, J. C., Sousa, G. L., et al. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20142322 · Cited by 682 · see citing works
Neuroinflammation pathways: a general review
Shabab, T., Khanabdali, R., Moghadamtousi, S. Z., Kadir, H. A., & Mohan, G. (2016) · International Journal of Neuroscience · doi:10.1080/00207454.2016.1212854 · Cited by 637 · see citing works
Pharmacological profiles of cloned mammalian P2Y-receptor subtypes
von Kügelgen, I. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.08.014 · Cited by 541 · see citing works
Microglial subtypes: diversity within the microglial community
Stratoulias, V., Venero, J. L., Tremblay, M., & Joseph, B. (2019) · The EMBO Journal · doi:10.15252/embj.2019101997 · Cited by 536 · see citing works
Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex
Sipe, G. O., Lowery, Tremblay, M.-È., Kelly, E. A., Lamantia, C. E., & Majewska, A. K. (2016) · Nature Communications · doi:10.1038/ncomms10905 · Cited by 512 · see citing works
Eyo, U. B., Peng, J., Swiatkowski, P., Mukherjee, A., Bispo, A., & Wu, L.-J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0416-14.2014 · Cited by 509 · see citing works
A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity
Weiner, O. D., Neilsen, P. O., Prestwich, G. D., Kirschner, M. W., Cantley, L. C., & Bourne, H. R. (2002) · Nature Cell Biology · doi:10.1038/ncb811 · Cited by 506 · see citing works
Age-related alterations in the dynamic behavior of microglia
Damani, M. R., Zhao, L., Fontainhas, A. M., Amaral, J., Fariss, R. N., & Wong, W. T. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2010.00660.x · Cited by 504 · see citing works
NLRP3 inflammasome in neurological diseases, from functions to therapies
Song, L., Pei, L., Yao, S., Wu, Y., & Shang, Y. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00063 · Cited by 467 · see citing works
Madry, C., Kyrargyri, V., Arancibia-Cárcamo, I. L., Jolivet, R., Kohsaka, S., Bryan, R. M., & Attwell, D. (2018) · Neuron · doi:10.1016/j.neuron.2017.12.002 · Cited by 464 · see citing works
Bidirectional Microglia–Neuron Communication in Health and Disease
Szepesi, Z., Manouchehrian, O., Bachiller, S., & Deierborg, T. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00323 · Cited by 459 · see citing works
Structure of the human P2Y12 receptor in complex with an antithrombotic drug
Zhang, K., Zhang, J., Gao, Z., Zhang, D., Zhu, L., Han, G. W., Moss, S. M., Paoletta, S., Kiselev, E., Lu, W., et al. (2014) · Nature · doi:10.1038/nature13083 · Cited by 400 · see citing works
Purinergic receptor P2RY12-dependent microglial closure of the injured blood–brain barrier
Lou, N., Takano, T., Pei, Y., Xavier, A. L., Goldman, S. A., & Nedergaard, M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520398113 · Cited by 364 · see citing works
Butovsky, O., Jedrychowski, M. P., Cialic, R., Krasemann, S., Murugaiyan, G., Fanek, Z., Greco, D. J., Wu, P. M., Doykan, C. E., Kiner, O., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24304 · Cited by 358 · see citing works
Agonist-bound structure of the human P2Y12 receptor
Zhang, J., Zhang, K., Gao, Z., Paoletta, S., Zhang, D., Han, G. W., Li, T., Ma, L., Zhang, W., Müller, C. E., et al. (2014) · Nature · doi:10.1038/nature13288 · Cited by 349 · see citing works
Purine and purinergic receptors
Burnstock, G. (2018) · Brain and Neuroscience Advances · doi:10.1177/2398212818817494 · Cited by 330 · see citing works
Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury
Kumar, A., Stoica, B. A., Loane, D. J., Yang, M., Abulwerdi, G. A., Khan, N., Kumar, A., Thom, S. R., & Faden, A. I. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0819-4 · Cited by 318 · see citing works
Mildner, A., Huang, H., Radke, J., Stenzel, W., & Priller, J. (2017) · Glia · doi:10.1002/glia.23097 · Cited by 301 · see citing works
Microglia–Neuron Communication in Epilepsy
Eyo, U. B., Murugan, M., & Wu, L. (2016) · Glia · doi:10.1002/glia.23006 · Cited by 290 · see citing works
Avignone, E., Ulmann, L., Levavasseur, F., Rassendren, F., & Audinat, É. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1820-08.2008 · Cited by 286 · see citing works
ATP as a multi-target danger signal in the brain
Rodrigues, R. J., Tomé, Â. R., & Cunha, R. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00148 · Cited by 262 · see citing works
Microglia: Housekeeper of the Central Nervous System
Kabba, J. A., Xu, Y., Christian, H., Ruan, W., Kitchen, C., Xiang, Y., Zhang, L., Saavedra, J. M., & Pang, T. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0504-2 · Cited by 251 · see citing works
Preclinical and Clinical Studies with Selective Reversible Direct P2Y12Antagonists
van Giezen, J. J. J., & Humphries, R. G. (2005) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2005-869525 · Cited by 250 · see citing works
Autocrine Purinergic Receptor Signaling Is Essential for Macrophage Chemotaxis
Kronlage, M., Song, J., Sorokin, L. M., Isfort, K., Schwerdtle, T., Leipziger, J., Robaye, B., Conley, P. B., Kim, H., Sargin, S., et al. (2010) · Science Signaling · doi:10.1126/scisignal.2000588 · Cited by 250 · see citing works
Pharmacology and structure of P2Y receptors
von Kügelgen, I., & Hoffmann, K. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.030 · Cited by 246 · see citing works
Update of P2Y receptor pharmacology: IUPHAR Review 27
Jacobson, K. A., Delicado, E. G., Gachet, C., Kennedy, C., von Kügelgen, I., Li, B., Miras‐Portugal, M. T., Novak, I., Schöneberg, T., Pérez‐Sen, R., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15005 · Cited by 241 · see citing works
Springthorpe, B., Bailey, A., Barton, P., Birkinshaw, T. N., Bonnert, R. V., Brown, R. C., Chapman, D., Dixon, J., Guile, S. D., Humphries, R. G., et al. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.07.057 · Cited by 237 · see citing works
Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNS
Illés, P., Rubini, P., Ulrich, H., Zhao, Y., & Tang, Y. (2020) · Cells · doi:10.3390/cells9051108 · Cited by 235 · see citing works
Role of Platelets in Leukocyte Recruitment and Resolution of Inflammation
Rossaint, J., Margraf, A., & Zarbock, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02712 · Cited by 229 · see citing works
Cattaneo, M. (2010) · Circulation · doi:10.1161/circulationaha.109.853069 · Cited by 219 · see citing works
P2Y12 expression and function in alternatively activated human microglia
Moore, C. S., Ase, A. R., Kinsara, A., Rao, V. T. S., Michell-Robinson, M., Leong, S. Y., Butovsky, O., Ludwin, S. K., Séguéla, P., Bar-Or, A., et al. (2015) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000080 · Cited by 212 · see citing works
The benefits of neuroinflammation for the repair of the injured central nervous system
Yong, H. Y. F., Rawji, K. S., Ghorbani, S., Xue, M., & Yong, V. W. (2019) · Cellular & Molecular Immunology · doi:10.1038/s41423-019-0223-3 · Cited by 190 · see citing works
P2Y12 receptors: structure and function
Cattaneo, M. (2015) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12952 · Cited by 185 · see citing works
Koizumi, S., Ohsawa, K., Inoue, K., & Kohsaka, S. (2013) · Glia · doi:10.1002/glia.22358 · Cited by 184 · see citing works
Fekete, R., Cserép, C., Lénárt, N., Tóth, K., Orsolits, B., Martinecz, B., Méhes, E., Szabó, B., Németh, V., Gönci, B., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1885-0 · Cited by 184 · see citing works
Soluble phospho-tau from Alzheimer’s disease hippocampus drives microglial degeneration
Sanchez-Mejias, E., Navarro, V., Jimenez, S., Sanchez-Mico, M., Sanchez-Varo, R., Nuñez-Diaz, C., Trujillo-Estrada, L., Davila, J. C., Vizuete, M., Gutierrez, A., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1630-5 · Cited by 175 · see citing works
Braun, N., Sévigny, J., Robson, S. C., Enjyoji, K., Guckelberger, O., Hammer, K., Virgilio, F. D., & Zimmermann, H. (2000) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2000.01342.x · Cited by 169 · see citing works
van Wageningen, T. A., Vlaar, E., Kooij, G., Jongenelen, C. A. M., Geurts, J. J. G., & van Dam, A.-M. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0850-z · Cited by 147 · see citing works
Ullrich (2018) · doi:10.1038/mp.2017.188 · Cited by 145 · see citing works
Beaino, W., Janssen, B., Kooij, G., van der Pol, S. M. A., Hof, B. V. H., van Horssen, J., Windhorst, A. D., & de Vries, H. E. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1034-z · Cited by 141 · see citing works
P2Y12 receptors in platelets and other hematopoietic and non-hematopoietic cells
Gachet, C. (2012) · Purinergic Signalling · doi:10.1007/s11302-012-9303-x · Cited by 140 · see citing works
Microglia and the Purinergic Signaling System
Calovi, S., Mut-Arbona, P., & Sperlágh, B. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.12.021 · Cited by 133 · see citing works
Walker, D. G., Tang, T. M., Mendsaikhan, A., Tooyama, I., Serrano, G. E., Sue, L. I., Beach, T. G., & Lue, L.-F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020678 · Cited by 128 · see citing works
Expression of P2 nucleotide receptors varies with age and sex in murine brain microglia
Crain, J. M., Nikodémová, M., & Watters, J. J. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-24 · Cited by 122 · see citing works
Effects of ticlopidine, a new platelet aggregation inhibitor in man
Thebault, J. J., Blatrix, C. E., Blanchard, J., & Panak, E. (1975) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1975184485 · Cited by 119 · see citing works
Eyo, U. B., Peng, J., Murugan, M., Mo, M., Lalani, A., Xie, P., Xu, P., Margolis, D. J., & Wu, L. (2016) · eNeuro · doi:10.1523/eneuro.0209-16.2016 · Cited by 114 · see citing works
Microglia: Brain cells on the move
Smolders, S., Kessels, S., Vangansewinkel, T., Rigo, J., Legendre, P., & Brône, B. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.04.001 · Cited by 114 · see citing works
Microglial P2Y12 Deficiency/Inhibition Protects against Brain Ischemia
Webster, C. M., Hokari, M., McManus, A., Tang, X. N., Ma, H., Kacimi, R., & Yenari, M. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070927 · Cited by 109 · see citing works
Taib, T., Leconte, C., Steenwinckel, J. V., Cho, A. H., Palmier, B., Torsello, E., Lai–Kuen, R., Onyeomah, S., Ecomard, K., Benedetto, C., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184811 · Cited by 105 · see citing works
Self-citationPurinergic mechanisms in neuroinflammation: An update from molecules to behavior
Beamer, E. H., Gölöncsér, F., Horváth, G., Bekő, K., Otrokocsi, L., Koványi, B., & Sperlágh, B. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.09.019 · Cited by 103 · see citing works
Signaling Pathways Controlling Microglia Chemotaxis
Yang, F., Xie, L., & Chung, C. Y. (2017) · Molecules and Cells · doi:10.14348/molcells.2017.0011 · Cited by 103 · see citing works
The ectonucleotidase cd39/ENTPDase1 modulates purinergic‐mediated microglial migration
Färber, K., Markworth, S., Pannasch, U., Nolte, C., Prinz, V., Kronenberg, G., Gertz, K. R., Endres, M., Bechmann, I., Enjyoji, K., et al. (2007) · Glia · doi:10.1002/glia.20606 · Cited by 102 · see citing works
P2Y12 Inhibition beyond Thrombosis: Effects on Inflammation
Mansour, A., Bachelot‐Loza, C., Nesseler, N., Gaussem, P., & Gouin‐Thibault, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041391 · Cited by 101 · see citing works
New Insights into Microglia–Neuron Interactions: A Neuron’s Perspective
Pósfai, B., Cserép, C., Orsolits, B., & Dénes, Á. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2018.04.046 · Cited by 98 · see citing works
Algaier, I., Jakubowski, J. A., Asai, F., & von Kügelgen, I. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.03136.x · Cited by 94 · see citing works
Role of the P2Y12 Receptor in the Modulation of Murine Dendritic Cell Function by ADP
Addi, A. B., Cammarata, D., Conley, P. B., Boeynaems, J., & Robaye, B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901799 · Cited by 90 · see citing works
von Kügelgen, I. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.03.010 · Cited by 89 · see citing works
Gelosa, P., Lecca, D., Fumagalli, M., Wypych, D., Pignieri, A., Cimino, M., Verderio, C., Enerbäck, M., Nikookhesal, E., Tremoli, E., et al. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.45 · Cited by 85 · see citing works
Zhu, C., Kros, J. M., van der Weiden, M., Zheng, P., Cheng, C., & Mustafa, D. A. M. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0405-5 · Cited by 81 · see citing works
Matyash, M., Zabiegalov, O., Wendt, S., Matyash, V., & Kettenmann, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175012 · Cited by 80 · see citing works
A Central Role for ATP Signalling in Glial Interactions in the CNS
Rivera, A. D., Vanzulli, I., & Butt, A. M. (2016) · Current Drug Targets · doi:10.2174/1389450117666160711154529 · Cited by 74 · see citing works
P2Y12 receptor protein in cortical gray matter lesions in multiple sclerosis.
Amadio, S., Montilli, C., Magliozzi, R., Bernardi, G., Reynolds, R., & Volonte, C. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhp193 · Cited by 73 · see citing works
Identification of the active metabolite of ticlopidine from rat in vitro metabolites
Yoneda, K., Iwamura, R., Kishi, H., Mizukami, Y., Mogami, K., & Kobayashi, S. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705808 · Cited by 71 · see citing works
P2Y12Receptor on the Verge of a Neuroinflammatory Breakdown
Amadio, S., Parisi, C., Montilli, C., Carrubba, A. S., Apolloni, S., & Volonté, C. (2014) · Mediators of Inflammation · doi:10.1155/2014/975849 · Cited by 69 · see citing works
Extracellular ADP augments microglial inflammasome and NF‐κB activation via the P2Y12 receptor
Suzuki, T., Kohyama, K., Moriyama, K., Ozaki, M., Hasegawa, S., Ueno, T., Saitoe, M., Morio, T., Hayashi, M., & Sakuma, H. (2019) · European Journal of Immunology · doi:10.1002/eji.201848013 · Cited by 69 · see citing works
The Role of P2Y12 Receptor and Activated Platelets During Inflammation
Liverani, E., Kilpatrick, L. E., Tsygankov, A. Y., & Kunapuli, S. P. (2014) · Current Drug Targets · doi:10.2174/1389450115666140519162133 · Cited by 56 · see citing works
A story of birth and death: Insights into the formation and dynamics of the microglial population
Askew, K. E., & Gómez‐Nicola, D. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.03.009 · Cited by 55 · see citing works
P2Y Receptors in Immune Response and Inflammation
Duc, D. L., Schulz, A., Lede, V., Schulze, A., Thor, D., Brüser, A., & Schöneberg, T. (2017) · Advances in immunology · doi:10.1016/bs.ai.2017.05.006 · Cited by 50 · see citing works
Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease
Chagas, L. D. S., Sandre, P. C., Ribeiro, N. C. A. R. E., Marcondes, H., Silva, P. O., Savino, W., & Serfaty, C. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062111 · Cited by 50 · see citing works
The Metabolism of Clopidogrel: CYP2C19 Is a Minor Pathway
Ford, N. F. (2016) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.769 · Cited by 45 · see citing works
Yanachkov, I. B., Chang, H., Yanachkova, M. I., Dix, E. J., Berny‐Lang, M. A., Gremmel, T., Michelson, A. D., Wright, G. E., & Frelinger, A. L. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.10.055 · Cited by 44 · see citing works
Age Influences Microglial Activation After Cuprizone-Induced Demyelination
Klein, B., Mrowetz, H., Barker, C. M., Lange, S., Rivera, F. J., & Aigner, L. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00278 · Cited by 42 · see citing works
Remko, M., Remková, A., & Broer, R. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030388 · Cited by 41 · see citing works
UDP Facilitates Microglial Phagocytosis Through P2Y6 Receptors
Inoue, K. (2007) · Cell Adhesion & Migration · doi:10.4161/cam.1.3.4937 · Cited by 38 · see citing works
Satonaka, H., Nagata, D., Takahashi, M., Kiyosue, A., Myojo, M., Fujita, D., Ishimitsu, T., Nagano, T., Nagai, R., & Hirata, Y. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00862.2013 · Cited by 37 · see citing works
Deciphering biased inverse agonism of cangrelor and ticagrelor at P2Y12 receptor
Garcia, C., Ribes, A. M., Nauze, M., N’Guyen, D., Martinez, L. O., Payrastre, B., Sénard, J., Galès, C., & Pons, V. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2960-3 · Cited by 35 · see citing works
Microglia-mediated synaptic elimination in neuronal development and disease
Whitelaw, B. S. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00021.2017 · Cited by 28 · see citing works
Inhibition Mechanism of the Recombinant Rat P2X2Receptor in Glial Cells by Suramin and TNP-ATP
Trujillo, C. A., Nery, A. A., Martins, A. H. B., Majumder, P., Gonzalez, F. A., & Ulrich, H. (2005) · Biochemistry · doi:10.1021/bi051517w · Cited by 27 · see citing works
Högberg, C., Gidlöf, O., Deflorian, F., Jacobson, K. A., Abdelrahman, A., Müller, C. E., Olde, B., & Erlinge, D. (2012) · Thrombosis and Haemostasis · doi:10.1160/th11-10-0749 · Cited by 11 · see citing works
Uridine Triphosphate Thio Analogues Inhibit Platelet P2Y12 Receptor and Aggregation
Gündüz, D., Tanislav, C., Sedding, D., Parahuleva, M. S., Santoso, S., Troidl, C., Hamm, C. W., & Aslam, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020269 · Cited by 11 · see citing works
Advances in Antiplatelet Therapy for Stroke Prevention: the New P2Y12 antagonists
Giossi, A., Pezzini, A., Zotto, E. D., Volonghi, I., Costa, P., Ferrari, D., & Padovani, A. (2010) · Current Drug Targets · doi:10.2174/138945010790711987 · Cited by 10 · see citing works
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Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371 · see citing works
Beyond Activation: Characterizing Microglial Functional Phenotypes
Lier, J., Streit, W. J., & Bechmann, I. (2021) · Cells · doi:10.3390/cells10092236 · Cited by 274 · see citing works
“As shown in studies using single-cell RNA sequencing in Alzheimer’s disease and other neurodegenerative conditions, P2RY12 is one of the proteins marking the transition from homeostatic microglia to disease-associated microglia by the downregulation of gene expression [55,61].”
BackgroundResultHuman Microglia Show Unique Transcriptional Changes in Alzheimer's Disease
Prater, K. E., Green, K. J., Mamde, S., Sun, W., Cochoit, A., Smith, C. L., Chiou, K. L., Heath, L., Rose, S. E., Wiley, J., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00424-y · Cited by 164 · see citing works
Retinal microglia: Functions and diseases
Fan, W., Huang, W., Chen, J., Li, N., Mao, L., & Hou, S. (2022) · Immunology · doi:10.1111/imm.13479 · Cited by 131 · see citing works
Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution
Martirosyan, A., Ansari, R. A., Pestana, F., Hebestreit, K., Gasparyan, H. A., Aleksanyan, R., Hnatova, S., Poovathingal, S. K., Marneffe, C., Thal, D. R., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00699-0 · Cited by 134 · see citing works
Miao, Y., Zhao, G., Cheng, S., Wang, Z., & Yang, X.-L. (2023) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2023.101169 · Cited by 124 · see citing works
Microglial morphometric analysis: so many options, so little consistency
Reddaway, J., Richardson, P., Bevan, R. J., Stoneman, J., & Palombo, M. (2023) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2023.1211188 · Cited by 119 · see citing works
Quantifying microglial morphology: an insight into function
Green, T. R. F., & Rowe, R. K. (2024) · Clinical & Experimental Immunology · doi:10.1093/cei/uxae023 · Cited by 106 · see citing works
Microglia dynamics in aging-related neurobehavioral and neuroinflammatory diseases
Javanmehr, N., Saleki, K., Alijanizadeh, P., & Rezaei, N. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02637-1 · Cited by 103 · see citing works
Han, Q.-Q., & Le, W. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01023-y · Cited by 91 · see citing works
Neurovascular unit, neuroinflammation and neurodegeneration markers in brain disorders
Kempuraj, D., Dourvetakis, K. D., Cohen, J., Valladares, D. S., Joshi, R. S., Kothuru, S. P., Anderson, T., Chinnappan, B., Cheema, A. K., Klimas, N. G., et al. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1491952 · Cited by 75 · see citing works
Towards PET imaging of the dynamic phenotypes of microglia
Beaino, W., Janssen, B., Vugts, D. J., de Vries, H. E., & Windhorst, A. D. (2021) · Clinical & Experimental Immunology · doi:10.1111/cei.13649 · Cited by 61 · see citing works
STAMarker: determining spatial domain-specific variable genes with saliency maps in deep learning
Zhang, C., Dong, K., Aihara, K., Chen, L., & Zhang, S. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad801 · Cited by 52 · see citing works
Brain region- and sex-specific transcriptional profiles of microglia
Barko, K., Shelton, M. A., Xue, X., Afriyie-Agyemang, Y., Puig, S., Freyberg, Z., Tseng, G. C., Logan, R. W., & Seney, M. L. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.945548 · Cited by 51 · see citing works
Glioblastoma microenvironment—from biology to therapyPreprint
Read, R. D., Tapp, Z. M., Rajappa, P., & Hambardzumyan, D. (2024) · Genes & Development · doi:10.1101/gad.351427.123 · Cited by 46 · see citing works
Entsie, P., Kang, Y., Amoafo, E. B., Schöneberg, T., & Liverani, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076709 · Cited by 45 · see citing works
Zhang, P., Gao, C., Guo, Q., Yang, D., Zhang, G., Lü, H., Zhang, L., Zhang, G., & Li, D. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03113-8 · Cited by 43 · see citing works
Leukotrienes vs. Montelukast—Activity, Metabolism, and Toxicity Hints for Repurposing
Marques, C. F., Marques, M. M., & Justino, G. C. (2022) · Pharmaceuticals · doi:10.3390/ph15091039 · Cited by 43 · see citing works
Modulating Neuroinflammation as a Prospective Therapeutic Target in Alzheimer’s Disease
Lee, E., & Chang, Y. (2025) · Cells · doi:10.3390/cells14030168 · Cited by 38 · see citing works
Antiplatelet drugs: Potential therapeutic options for the management of neurodegenerative diseases
Beura, S. K., Dhapola, R., Panigrahi, A. R., Yadav, P., Kumar, R., HariKrishnaReddy, D., & Singh, S. K. (2023) · Medicinal Research Reviews · doi:10.1002/med.21965 · Cited by 35 · see citing works
Shen, Y., Liu, F., & Zhang, M. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117235 · Cited by 36 · see citing works
Engel, T., Smith, J., & Alves, M. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s287740 · Cited by 36 · see citing works
You, S., Su, X., Ying, J., Li, S., Qu, Y., & Mu, D. (2022) · Biomolecules · doi:10.3390/biom12081158 · Cited by 35 · see citing works
Lee, J., Kim, S. W., & Kim, K. (2022) · Cells · doi:10.3390/cells11121902 · Cited by 34 · see citing works
Zhao, W., Liu, Z., Wu, J., Liu, A., & Yan, J. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01343 · Cited by 34 · see citing works
Neuroinflammation Biomarkers in the AT(N) Framework Across the Alzheimer's Disease Continuum
Bieger, A., Rocha, A., Bellaver, B., Machado, L. S., Ros, L. U. D., Borelli, W. V., Therriault, J., Macedo, A. C., Pascoal, T. A., Gauthier, S. G., et al. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.54 · Cited by 29 · see citing works
Genetic insights into immune mechanisms of Alzheimer’s and Parkinson’s disease
Nott, A., & Holtman, I. R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1168539 · Cited by 31 · see citing works
Évora, A., Garcia, G., Rubi, A., Vitis, E. D., Matos, A. T., Vaz, A. R., Gervaso, F., Gigli, G., Polini, A., & Brites, D. M. T. O. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1474012 · Cited by 30 · see citing works
Glial Cell Dynamics in Neuroinflammation: Mechanisms, Interactions, and Therapeutic Implications
García‐Domínguez, M. (2026) · Biomedicines · doi:10.3390/biomedicines14010115 · Cited by 29 · see citing works
Sun, J., Chen, F., She, L., Zeng, Y., Tang, H., Ye, B., Zheng, W., Xiong, L., Li, L., Li, L., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.11.020 · Cited by 24 · see citing works
Škandík, M., Frieß, L., Vázquez-Cabrera, G., Keane, L., Grabert, K., Santos, M. C. D. L., Posada-Pérez, M., Balevičiūtė, A., Cheray, M., & Joseph, B. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02295-1 · Cited by 26 · see citing works
Trehalose Treatment in Zebrafish Model of Lafora Disease
Vecchia, S. D., Ogi, A., Licitra, R., Abramo, F., Nardi, G., Mero, S., Landi, S., Battini, R., Sicca, F., Ratto, G. M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126874 · Cited by 23 · see citing works
McGeachan, R. I., Meftah, S., Taylor, L. W., Catterson, J. H., Negro, D., Bonthron, C., Holt, K., Tulloch, J., Rose, J. L., Gobbo, F., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58879-z · Cited by 23 · see citing works
You, Y., Chen, Z., & Hu, W. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108606 · Cited by 22 · see citing works
Neuroinflammation and iron metabolism after intracerebral hemorrhage: a glial cell perspective
Ju, J.-J., & Hang, L. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2024.1510039 · Cited by 22 · see citing works
Mitochondrially-Targeted Therapeutic Strategies for Alzheimer’s Disease
Onyango, I. G., Bennett, J. P., & Stokin, G. B. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666211208125855 · Cited by 21 · see citing works
Asveda, T., Talwar, P., & Ravanan, P. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121920 · Cited by 22 · see citing works
Hanin, A., Zhang, L., Huttner, A. J., Plu, I., Mathon, B., Bielle, F., Navarro, V., Hirsch, L. J., & Hafler, D. A. (2024) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000200259 · Cited by 22 · see citing works
Molecular Mechanisms of Chronic Pain and Therapeutic Interventions
Li, Z., Li, X., Liu, J., Sun, R., Ye, Y., Xiang, H., Luo, F., Li, S., & Luo, A. (2025) · MedComm · doi:10.1002/mco2.70325 · Cited by 26 · see citing works
Short-Term Sleep Fragmentation Dysregulates Autophagy in a Brain Region-Specific Manner
Cheng, Y., Kim, W., Wellman, L. L., Sanford, L. D., & Guo, M. (2021) · Life · doi:10.3390/life11101098 · Cited by 21 · see citing works
Güvenek, A., Parikshak, N., Zamolodchikov, D., Gelfman, S., Moscati, A., Dobbyn, L., Stahl, E. A., Shuldiner, A. R., & Coppola, G. (2024) · Communications Biology · doi:10.1038/s42003-024-06684-7 · Cited by 23 · see citing works
Tsourmas, K. I., Butler, C. A., Kwang, N. E., Sloane, Z. R., Dykman, K. J. G., Maloof, G. O., Choudhury, B., Paulchakrabarti, M., Prekopa, C. A., Tabaie, E. Z., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63237-0 · Cited by 24 · see citing works
Impact of Caffeine on Alzheimer’s Disease Pathogenesis—Protective or Risk Factor?
Schreiner, T. G., & Popescu, B. O. (2022) · Life · doi:10.3390/life12030330 · Cited by 22 · see citing works
Chen, D., Jiang, H., Sun, L., Nurzat, Y., Qin, H., Zhao, Z., Liu, D., Zheng, S., Wang, L., Fu, Y., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03730-2 · Cited by 19 · see citing works
Microbiota mitochondria disorders as hubs for early age-related macular degeneration
Fehér, J., Élő, Á., István, L., Nagy, Z. Z., Radak, Z. O., Scuderi, G., Artico, M., & Kovács, I. (2022) · GeroScience · doi:10.1007/s11357-022-00620-5 · Cited by 19 · see citing works
Bobotis, B. C., Halvorson, T., Carrier, M., & Tremblay, M. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1317125 · Cited by 21 · see citing works
Bertin, É., Martínez, A., Fayoux, A., Carvalho, K., Carracedo, S., Fernagut, P., Koch‐Nolte, F., Blum, D. L., Bertrand, S. S., & Boué‐Grabot, É. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04461-5 · Cited by 19 · see citing works
Zhang, Z., Niu, K., Huang, T., Guo, J., Xarbat, G., Gong, X., Gao, Y., Liu, F., Shan, C., Su, W., et al. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-024-00846-4 · Cited by 19 · see citing works
Geraci, J., Bhargava, R., Qorri, B., Leonchyk, P., Cook, D. J., Cook, M., Sie, F., & Pani, L. (2024) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2023.1199736 · Cited by 18 · see citing works
Sex-dependent effects of a high-fat diet on the hypothalamic response in mice
Dreux, V., Lefebvre, C., Breemeersch, C.-E., Salaün, C., Bôle‐Feysot, C., Guérin, C., Déchelotte, P., Goichon, A., Coëffier, M., & Langlois, L. D. (2025) · Biology of Sex Differences · doi:10.1186/s13293-025-00699-3 · Cited by 18 · see citing works
Miao, G., Fortier, T. M., Liu, H., Schafer, D. P., Fitzgerald, K. A., Mao, J., & Baehrecke, E. H. (2025) · Nature Structural & Molecular Biology · doi:10.1038/s41594-025-01602-9 · Cited by 17 · see citing works
Moya-Gómez, A., Font, L. P., Burlacu, A., Alpizar, Y. A., Cardonne, M. M., Brône, B., & Bronckaers, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311117 · Cited by 17 · see citing works
Advanced brain imaging for the diagnosis of Alzheimer disease
Wang, Y.-T. T., Rosa‐Neto, P., & Gauthier, S. G. (2023) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001198 · Cited by 17 · see citing works
Microglial purinergic signaling in Alzheimer’s disease
Mei, S.-Y., Zhang, N., Wang, M., Lv, P.-R., & Liu, Q. (2024) · Purinergic Signalling · doi:10.1007/s11302-024-10029-8 · Cited by 18 · see citing works
MicroRNAs Modulating Neuroinflammation in Parkinson's disease
Saadh, M. J., Muhammad, F. A., Singh, A., Mustafa, M. A., Zuhairi, R. A. H. A., Ghildiyal, P., Hashim, G. M., Alsaikhan, F., Khalilollah, S., & Akhavan‐Sigari, R. (2024) · Inflammation · doi:10.1007/s10753-024-02125-z · Cited by 16 · see citing works
Ye, T., Fan, Y., Zeng, X., Wang, X., & Xiao, H. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000002257 · Cited by 15 · see citing works
Naffaa, M. M. (2025) · Exploration of neuroscience · doi:10.37349/en.2025.100676 · Cited by 17 · see citing works
Bathe, T., Hery, G. P., Villareal, J. A. B., Phillips, J. L., Cohen, E. M., Sharma, R. V., Tsering, W., & Prokop, S. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01770-7 · Cited by 14 · see citing works
Nheu, D., Ellen, O., Ye, S., Öztürk, E., Pagnin, M., Kertadjaja, S., Theotokis, P., Grigoriadis, N., McLean, C., & Petratos, S. (2022) · Cells · doi:10.3390/cells11233768 · Cited by 16 · see citing works
P2Y12 receptor gene polymorphisms are associated with epilepsy
Wang, Q., Shi, N.-R., Lv, P., Liu, J., Zhang, J., Deng, B.-L., Zuo, Y.-Q., Yang, J., Wang, X., Chen, X., et al. (2022) · Purinergic Signalling · doi:10.1007/s11302-022-09848-4 · Cited by 15 · see citing works
Wang, P., Mi, Y., Yu, H. N., Teng, X., Jin, S., Xiao, L., Xue, H., Tian, D., Guo, Q., & Wu, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116549 · Cited by 14 · see citing works
The Multifaceted Role of GPCRs in Amyotrophic Lateral Sclerosis: A New Therapeutic Perspective?
Bassani, D., Pavan, M., Federico, S., Spalluto, G., Sturlese, M., & Moro, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094504 · Cited by 13 · see citing works
Xu, N., Liu, Z., Yang, Q., Bian, P., Li, M., & Zhao, X. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.906447 · Cited by 13 · see citing works
Huang, T., Wu, J., Mu, J., & Gao, J. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00605 · Cited by 13 · see citing works
Spinal Cord Injury Management Based on Microglia-Targeting Therapies
Schreiner, T. G., Schreiner, O. D., & Ciobanu, R. C. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13102773 · Cited by 13 · see citing works
Arutyunov, A., Durán‐Laforet, V., Ai, S., Ferrari, L. L., Murphy, R., Schafer, D. P., & Klein, R. S. (2024) · Biomolecules · doi:10.3390/biom14070808 · Cited by 14 · see citing works
Platelets: A new therapeutic target for neurological diseases
Wei, X., & Tang, X.-Q. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102874 · Cited by 12 · see citing works
Inflammation in Health and Disease: New Insights and Therapeutic Avenues
Scotece, M., & Conde, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158392 · Cited by 12 · see citing works
Chun, B. J., Aryal, S. P., Varughese, P., Sun, B., Bruno, J., Richards, C. I., Bachstetter, A. D., & Kekenes-Huskey, P. M. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2022.1037417 · Cited by 10 · see citing works
Zhang, W., Li, M., Wang, C., Feng, X., Hu, D.-X., Wu, L., & Hu, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114975 · Cited by 11 · see citing works
Microglial proliferation and astrocytic protein alterations in the human Huntington's disease cortex
Tan, A. Y. S., Tippett, L. J., Turner, C. P., Swanson, M. E. V., Park, T., Curtis, M. A., Faull, R. L. M., Dragunow, M., & Singh‐Bains, M. K. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106554 · Cited by 11 · see citing works
Loss of <i>Inpp5d</i> has disease‐relevant and sex‐specific effects on glial transcriptomes
Dabin, L. C., Kersey, H., Kim, B., Acri, D. J., Sharify, D., Lee‐Gosselin, A., Lasagna‐Reeves, C. A., Oblak, A. L., Lamb, B. T., & Kim, J. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13901 · Cited by 10 · see citing works
Metabolic and inflammatory roles of glial cells in neurodegenerative and cerebrovascular diseases
OGUNLEYE, F. A., Zhou, Y., Yan, L., Abhulimen, P. O., Xu, Y., Lai, M. K. P., Okunowo, W. O., Sethi, G., Fang, C., & Ma, Y. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103120 · Cited by 10 · see citing works
Roles of biomaterials in modulating the innate immune response in ocular therapy
Rafiei, M., Chung, J. T., & Chau, Y. (2023) · Frontiers in Drug Delivery · doi:10.3389/fddev.2023.1077253 · Cited by 10 · see citing works
Brezáni, V., Joshi, R., Ortega‐Ribera, M., Nagesh, P. T., Brezáni, V., Zivny, A., Kurt‐Jones, E. A., Golenbock, D. T., & Szabó, G. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03501-8 · Cited by 10 · see citing works
Diagnostic and therapeutic value of P2Y12R in epilepsy
Chen, X., Wang, Q., Yang, J., Zhang, L., Liu, T., Liu, J., Deng, B.-L., & Liu, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1179028 · Cited by 10 · see citing works
Goleij, P., Amini, A., Tabari, M. A. K., Hadipour, M., Rezaee, A., Daglia, M., Aschner, M., Sanaye, P. M., Kumar, A. P., & Khan, H. Z. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114399 · Cited by 9 · see citing works
Transcriptional Regulation of Microglial Metabolic and Activation States by P2RY12
Lopez‐Ortiz, A. O., Doceti, M., Thomas, J., Duffy, A., Coburn, M., Okojie, A. K., Lee, A., Sou, E. A., Gaultier, A., & Eyo, U. B. (2025) · Glia · doi:10.1002/glia.70078 · Cited by 11 · see citing works
Microglia at the scene of the crime: what their transcriptomics reveal about brain health
Arutyunov, A., & Klein, R. S. (2023) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001151 · Cited by 9 · see citing works
Germelli, L., Angeloni, E., Pozzo, E. D., Tremolanti, C., Felice, M. D., Giacomelli, C., Marchetti, L., Muscatello, B., Barresi, E., Taliani, S., et al. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05544-1 · Cited by 9 · see citing works
Fang, K. (2024) · Ibrain · doi:10.1002/ibra.12185 · Cited by 10 · see citing works
Liu, L., Li, P., Wilkerson, B. A., Wu, Y., Liu, M., Jiang, W., Hamlett, E. D., Carroll, S. L., & Fan, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1648278 · Cited by 8 · see citing works
A neuroimmune cerebral assembloid model to study the pathophysiology of familial Alzheimer’s disease
Becerra-Calixto, A., Banerjee, A., Fan, H., Tan, C., Lee, E., McCullough, L. D., & Lee, J. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03544-x · Cited by 8 · see citing works
Azadian, M. M., Shabestari, S. K., Rajan, A., Martinez, P. J., Macedo, N., Markarian, E., Xiang, Y., Yu, B. J., George, P. M., Fame, R. M., et al. (2025) · Nature Biotechnology · doi:10.1038/s41587-025-02866-8 · Cited by 9 · see citing works
Semaglutide attenuates neuroinflammation in male mice
Rausch, D. M., Ludwig, M. Q., Bentsen, M. A., Hansen, S. N., Secher, A., Holst, D., Moreno, J., Das, V., Egerod, K. L., Bjerregaard, A.-M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-74038-4 · Cited by 9 · see citing works
P2 Receptor Signaling in Motor Units in Muscular Dystrophy
Khairullin, A. E., Grishin, S. N., & Зиганшин, А. У. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021587 · Cited by 8 · see citing works
Zhang, T., Adams, C., Fejér, G., Ercolano, E., Cutajar, J., Na, J., Sahm, F., & Hanemann, C. O. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03419-2 · Cited by 7 · see citing works
Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population
Regal, J. A., García, M. E. G., Jain, V. K., Chandramohan, V., Ashley, D. M., Gregory, S. G., Thompson, E. M., Lopez, G. Y., & Reitman, Z. J. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01548-3 · Cited by 6 · see citing works
Wei, L., Wang, T., Luo, M., Zhang, S., Lu, M., Zhou, X., Cheng, X., Wang, H., & Xu, D. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110814 · Cited by 7 · see citing works
Coffee and Alzheimer's disease
Mirzaei, F., Agbaria, L., Bhatnagar, K., Sirimanne, N., A'amar, N. O., Jindal, V., Thilagendra, A. G., & Raba, F. T. (2024) · Progress in brain research · doi:10.1016/bs.pbr.2024.06.002 · Cited by 7 · see citing works
He, X., Yang, X., Li, G., Zhao, Y., Luo, J., Xu, J., Zheng, H., Zhang, L., & Hu, X. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04391-2 · Cited by 7 · see citing works
Chang, J., Li, Z., Yuan, H., Wang, X., Xu, J., Yang, P., & Qin, L. (2024) · Communications Biology · doi:10.1038/s42003-024-07215-0 · Cited by 7 · see citing works
Ferrucci, L., Basilico, B., Reverte, I., Pagani, F., Scaringi, G., Cordella, F., Cortese, B., Propris, G. D., Galeone, A., Mazzarella, L., et al. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1456974 · Cited by 7 · see citing works
Hisaoka‐Nakashima, K., Tokuda, S., Goto, T., Yoshii, N., Nakamura, Y., Ago, Y., & Morioka, N. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115590 · Cited by 7 · see citing works
The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases
Wyss, M. T., Heuer, C., & Herwerth, M. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.386405 · Cited by 7 · see citing works
Holtman, I. R., Glass, C. K., & Nott, A. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_29 · Cited by 6 · see citing works
Johansson, K. U. I., & Mohlin, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010871 · Cited by 6 · see citing works
Microglial Positron Emission Tomography Imaging In Vivo
Ottoy, J., Picker, L. D., & Kang, M. S. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_32 · Cited by 6 · see citing works
Stoessel, M. B., Stowell, R. D., Lowery, R. L., Le, L., Vu, A. N., Whitelaw, B. S., & Majewska, A. K. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.03.036 · Cited by 7 · see citing works
Wang, J., Song, W., Zhang, Y., Wang, J., Wang, Y., Song, J., & Zhou, Y. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04114-y · Cited by 5 · see citing works
- Authors
- Gómez Morillas, A., Besson, V. C., & Lerouet, D.
- Affiliations
- UMR-S1144–Optimisation Thérapeutique en Neuropsychopharmacologie (OTeN), Faculté de Pharmacie de Paris, 4 Avenue de l’Observatoire, Université de Paris, 75006 Paris, France
- Université Paris Cité (FR)
- Corresponding author
- Lerouet, Dominique
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2021-02-06
- Volume
- 22
- Issue
- 4
- Pages
- 1636
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7915979
- OpenAlex
- W3126430294
- Cited by
- 214
- References
- 96
- Citations by year
- 2026: 36 · 2025: 50 · 2024: 72 · 2023: 32 · 2022: 18 · 2021: 6
- FWCI
- 5.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fondation des Gueules Cassées
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- microglia, neuroinflammation, P2Y12 receptor, P2Y receptors, purinergic receptors, microglial motility, microglial migration, pharmacological tools, genetic instruments
- MeSH terms
- Brain, Brain Diseases, Cell Movement, Humans, Inflammation, Lymphocyte Activation, Signal Transduction, Microglia, Receptors, Purinergic P2Y12
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