Astrocytes in the initiation and progression of epilepsy

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Function and therapeutic value of astrocytes in neurological diseases

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IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures

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Gliotransmission: Beyond Black-and-White

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A ketogenic diet suppresses seizures in mice through adenosine A1 receptors

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Microglia–Neuron Communication in Epilepsy

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An Excitatory Loop with Astrocytes Contributes to Drive Neurons to Seizure Threshold

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Multiple Lines of Evidence Indicate That Gliotransmission Does Not Occur under Physiological Conditions

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Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats

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Seizure activity results in calcium- and mitochondria-independent ROS production via NADPH and xanthine oxidase activation

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Astrocytes as Guardians of Neuronal Excitability: Mechanisms Underlying Epileptogenesis

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The Interconnected Mechanisms of Oxidative Stress and Neuroinflammation in Epilepsy

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GABA as a rising gliotransmitter

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Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus

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Innate immune activation and neuroinflammatory pathways in Epilepsy.

Solanki, P., & Jha, S. (2025) · Cytokine & growth factor reviews · doi:10.1016/j.cytogfr.2025.06.009 · Cited by 15 · see citing works

Advances in understanding the role of inflammatory factors and immune cells in the pathology of epilepsy, mediated by neuroimmune interactions within the gut-brain axis

Zhang, L., Xu, R., Huang, H., Yang, J., Yu, C., Zhang, H., & Xu, Z. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1650909 · Cited by 14 · see citing works

Neuroinflammation in Epilepsy

Dingledine, R. J., Varvel, N. H., Ravizza, T., & Vezzani, A. (2024) · Oxford University Press eBooks · doi:10.1093/med/9780197549469.003.0030 · Cited by 13 · see citing works

A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders

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mtDNA leakage promotes neuron–glia crosstalk to induce epilepsy by cGAS–STING-driven neuroinflammation and serine metabolic reprogramming

Jiang, J., Zuo, M., Zhao, K., Ling, Z., Wu, Z., Xue, D., Mo, S., Liu, Y., Chen, Y., Wang, J., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2522313123 · Cited by 13 · see citing works

Targeting the Gut-Brain-Ferroptosis Axis: Molecular Mechanisms and Therapeutic Potential in Alzheimer’s Disease and Epilepsy

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The astrocyte α1A ‐adrenoreceptor is a key component of the neuromodulatory system in mouse visual cortex

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Targeting microglial GLP1R in epilepsy: A novel approach to modulate neuroinflammation and neuronal apoptosis

Zhang, K., Yang, Z., Yang, Z., Du, L., Zhou, Y., Fu, S., Wang, X., Liu, D., & He, X. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176903 · Cited by 12 · see citing works

Ligand-receptor interactions: A key to understanding microglia and astrocyte roles in epilepsy

Thergarajan, P., O'Brien, T. J., Jones, N. C., & Ali, I. Y. (2024) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2024.110219 · Cited by 13 · see citing works

Nanoengineered, ultrasmall and catalytic potassium calcium hexacyanoferrate for neuroprotection and temporal lobe epilepsy treatment

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Blocking salt‐inducible kinases with YKL‐06‐061 prevents PTZ‐induced seizures in mice

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The emerging role of miRNAs in epilepsy: From molecular signatures to diagnostic potential

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The Purinergic P2X7 Receptor as a Target for Adjunctive Treatment for Drug-Refractory Epilepsy

Sivakumar, D. T., Jain, K., Alfehaid, N., Wang, Y., Teng, X., Fischer, W., & Engel, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136894 · Cited by 11 · see citing works

Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting

Sandoval, K. E., & WITT, K. A. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.124.001117 · Cited by 14 · see citing works

Rett and Rett-related disorders: Common mechanisms for shared symptoms?

D’Mello, S. R. (2023) · Experimental Biology and Medicine · doi:10.1177/15353702231209419 · Cited by 12 · see citing works

Role of fragile X messenger ribonucleoprotein 1 in the pathophysiology of brain disorders: a glia perspective

D’Antoni, S., Spatuzza, M., Bonaccorso, C. M., & Catania, M. V. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105731 · Cited by 10 · see citing works

C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain

Crowley, G., Kim, M., O’Neill, N., Turkes, E., Ghasemi, F., Giudice, L., Schepper, S. D., Tan, B. J. Y., Maffei, B., Ferreira, L. S. S., et al. (2026) · Science · doi:10.1126/science.adv1219 · Cited by 14 · see citing works

Paramagnetic susceptibility measured by magnetic resonance imaging as an in vivo biomarker for iron pathology in epilepsy

Li, Z., Liu, Q., Xu, T., Zhang, M., Li, L., Chen, Z., Tang, Y., Jiang, L., Lü, Y., Yan, F., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads8149 · Cited by 10 · see citing works

The lncRNA Neat1 is associated with astrocyte reactivity and memory deficits in a mouse model of Alzheimer’s diseasePreprint

Irwin, A. B., Martina, V., Jago, S. S., Bahabry, R., Schreiber, A. M., & Lubin, F. D. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.03.539260 · Cited by 10 · see citing works

Late onset epilepsy and stroke: Diagnosis, pathogenesis and prevention

Stefan, H., & Michelson, G. (2024) · Seizure · doi:10.1016/j.seizure.2024.06.011 · Cited by 9 · see citing works

Regulatory T cells as a possible new target in epilepsy?

Hendrix, E., Vyver, M. V., Holt, M. G., & Smolders, I. J. (2024) · Epilepsia · doi:10.1111/epi.18038 · Cited by 9 · see citing works

Antioxidant Effects of Medicinal Plants for the Treatment of Epilepsy

Firdous, S. M., Mallik, S., & Paria, B. (2024) · Antioxidants · doi:10.1002/9781394270576.ch12 · Cited by 9 · see citing works

Astroglia’s role in synchronized spontaneous neuronal activity: from physiology to pathology

Ammothumkandy, A., Cayce, A., Shariq, M., & Bonaguidi, M. A. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1544460 · Cited by 8 · see citing works

Calcium-iron crosstalk in epileptogenesis: Unraveling mechanisms and therapeutic opportunities

Li, X., Tao, A.-L., Wu, N., Zhang, X., Xiao, F., Wang, J., & Wang, Z. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106989 · Cited by 10 · see citing works

Single-cell transcriptome analysis reveals dysregulation of microglial iron homeostasis in temporal lobe epilepsy

He, Z., Liu, S., Shi, W., Yang, Y., Wang, J., Wang, J., Yin, J., Shen, S., Zhou, D., & Li, J. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149885 · Cited by 10 · see citing works

Connexin hemichannel blockade by abEC1.1 disrupts glioblastoma progression, suppresses invasiveness, and reduces hyperexcitability in preclinical models

Donati, V., Pietro, C. D., Persano, L., Rampazzo, E., Panarelli, M., Cambria, C., Selimi, A., Manfreda, L., do Rêgo, A. G. D. O., Sala, G. L., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02370-1 · Cited by 8 · see citing works

Rodents’ visual gamma as a biomarker of pathological neural conditions

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Anakinra Promotes M2 Microglia Activation during the Latent Phase of the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy

Zakharova, M. V., Dyomina, A. V., Kovalenko, A. A., Zubareva, O. E., Ischenko, A. M., & Zaitsev, A. V. (2024) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093024020182 · Cited by 8 · see citing works

Efficacy and safety of Chinese herbal medicine in post-stroke epilepsy: a systematic review and meta-analysis

Sun, T., Wang, K., Li, L., Yan, M., Wu, J. H., & Liu, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1286093 · Cited by 7 · see citing works

FKBP51 is Involved in Epileptic Seizure by Regulating PSD95 in a PTZ-Induced Epileptic Mouse Model

Chen, L., Cui, W., Qin, J., Zhu, M., Zhang, H., Yang, J., Xu, Z., & Huang, H. (2025) · Journal of Integrative Neuroscience · doi:10.31083/jin25710 · Cited by 7 · see citing works

“Targeting Neuroimmune Pathways in Epilepsy: Advances in Mechanisms and Emerging Therapeutics”

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State of the art: glioma-associated epilepsy—bridging tumor biology and epileptogenesis

Divé, I., Luger, A., Muench, D., Weber, K. J., Steinbach, J. P., Rosenow, F., Winkler, F., & Zeiner, P. S. (2025) · Neurological Research and Practice · doi:10.1186/s42466-025-00434-8 · Cited by 7 · see citing works

Enlarged perivascular spaces in the basal ganglia across epilepsy subtypes

Sinclair, B., Yasuda, C. L., Nicolo, J., Hlauschek, G., Bezerra, T. M. S., Chen, Z. Z., Vivash, L. E., de Campos, B. M., João, R. B., Brioschi, R., et al. (2025) · Epilepsia · doi:10.1111/epi.18694 · Cited by 7 · see citing works

Astrocyte-derived complement C3 is activated in patients with tuberous sclerosis complex and mediates immune injury: an integrated bioinformatics analysis

Zhang, B., Qiao, J., Li, Q., Luan, G., & Qin, J. (2023) · Translational Pediatrics · doi:10.21037/tp-22-514 · Cited by 7 · see citing works

mTORC1 activation drives astrocyte reactivity in cortical tubers and brain organoid models of TSCPreprint

Li, T. L., Blair, J. D., Yoo, T., Grant, G. A., Hockemeyer, D. F., Porter, B. E., & Bateup, H. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.28.640914 · Cited by 8 · see citing works

Bursts of brain erosion: seizures and age-dependent neurological vulnerability

Cresto, N., Givalois, L., Badaut, J., Janvier, A., Génin, A., Audinat, É., Brewster, A. L., & Marchi, N. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2024.11.003 · Cited by 6 · see citing works

TREK-1 and epilepsy: regulating the balance of K+ and the glutamate release in astrocyte-neuron interactions

Yang, J., Li, L., Xu, Y., Guan, Y., & Li, X. (2025) · Behavioral and Brain Functions · doi:10.1186/s12993-025-00294-x · Cited by 6 · see citing works

Disrupted astrocyte-neuron signaling reshapes brain activity in epilepsy and Alzheimer’s disease

Wu, M., Zhang, R., Fu, P., & Mei, Y. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.02.029 · Cited by 6 · see citing works

Multiple‐Stimuli‐Responsive Biomimetic Polypyrrole Delivery System for Synergistic Regulation and Restoration of Epileptic Foci

Zhou, Z., Liu, M., You, H., Su, B., Wu, Y., Zhang, S., Sun, T., & Jiang, C. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202510305 · Cited by 5 · see citing works

Gastrodin from the Gastrodia elata Blume alleviates neuronal inflammation and injury via regulates NOX2/Nrf2 balance

Zhou, R., Wang, Y., Cao, X., Yuan, X., Li, L., & Zhang, W. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110620 · Cited by 5 · see citing works

Correlation between metabolism and neuroinflammation of astrocytes in drug-resistant epilepsy

Yu, X., Xu, D., Chen, S., Liu, Q., Wang, H., & Li, M. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13241-7 · Cited by 5 · see citing works

Astrocytic LCN2 drives neuronal dysfunction in epilepsy by suppressing tunnel nanotube-mediated mitochondrial transfer via NLRP3 inflammasome activation

Zhou, Z., Zhang, P., Jiang, Y., Xu, Y., Liu, F., Chen, X., Chen, D., Tang, W., Liao, R., & Liu, L. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.11.061 · Cited by 5 · see citing works

Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study

Thevissen, K., Ny, A., Copmans, D., Tits, J., Kamata, K., Gielis, E., Longin, K., Sourbron, J., Thergarajan, P., Tan, T., et al. (2025) · Epilepsia · doi:10.1111/epi.18536 · Cited by 5 · see citing works

Beyond the neuron: Unveiling the role of reactive astrocytes in epileptic seizure dynamics through self-organized bistability

Tsybina, Y., Kastalskiy, I. A., Kazantsev, V., Hramov, A. E., & Gordleeva, S. (2025) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2025.110980 · Cited by 5 · see citing works

Inferring disease progression stages in single-cell transcriptomics using a weakly supervised deep learning approachPreprint

Wehbe, F., Adams, L., Babadoudou, J., Yuen, S., Kim, Y.-S., & Tanaka, Y. (2024) · Genome Research · doi:10.1101/gr.278812.123 · Cited by 5 · see citing works

Astrocytes as a target for therapeutic strategies in epilepsy: current insights

Çarçak, N., Onat, F., & Sitnikova, E. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1183775 · Cited by 69 · see citing works

Epilepsy therapy beyond neurons: Unveiling astrocytes as cellular targets

Chen, Y., Hu, J., Zhang, Y., Peng, L., Li, X., Li, C., Wu, X., & Wang, C. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01035 · Cited by 18 · see citing works

Astrocytic Target Mechanisms in Epilepsy

Héja, L. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867320666131119160445 · Cited by 23 · see citing works

Astrocyte dysfunction in epilepsy

Seifert, G., Carmignoto, G., & Steinhäuser, C. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.10.004 · Cited by 287 · see citing works

Astrocytic function and its alteration in the epileptic brain

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