Glutamine synthetase immunoreactivity is present in oligodendroglia of various regions of the central nervous system
Abstract
Glutamine synthetase immunoreactive oligodendrocytes were identified in the cerebral cortex, cerebellum, brain stem, and spinal cord. They were mostly confined to the gray matter, particularly close to neurons and processes. The white matter showed few immunoreactive oligodendroglia. It was suggested that some type of oligodendrocytes, specially those in perineuronal location, might fulfill a functional role more akin to astrocytes than to the normally myelinating oligodendroglia.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Satellite oligodendrocytes function like astrocytes to take up synaptically released glutamate for conversion to glutamine and cycling back into neurons.
“Satellite oligodendrocytes are immunohistochemically reactive for glutamine synthetase, suggesting they function like astrocytes to take up synaptically released glutamate for conversion to glutamine and cycling back into neurons (D' Amelio et al, 1990).”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as D' Amelio et al, 1990
Satellite oligodendrocytes are immunohistochemically reactive for glutamine synthetase.
“Satellite oligodendrocytes are immunohistochemically reactive for glutamine synthetase, suggesting they function like astrocytes to take up synaptically released glutamate for conversion to glutamine and cycling back into neurons (D' Amelio et al, 1990).”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as D' Amelio et al, 1990
Cited by
Sorted by citations
Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,209 · see citing works
“For example, the common ‘‘short’’ allele of the functional 5-HTT LPR polymorphism increases the vulnerability for developing MDD within the context of stressful life events (Caspi et al. 2003).”
BackgroundBiology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
Baumann, N., & Pham-Dinh, D. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.871 · Cited by 1,828 · see citing works
Neurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606 · see citing works
Orbitofrontal cortex function and structure in depression
DREVETS, W. C. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.029 · Cited by 417 · see citing works
Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes
Hamidi, M., Drevets, W. C., & Price, J. L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.006 · Cited by 369 · see citing works
Brückner, G., Brauer, K., Härtig, W., Wolff, J. R., Rickmann, M. J., Derouiche, A., Delpech, B., Girard, N., Oertel, W. H., & Reichenbach, A. (1993) · Glia · doi:10.1002/glia.440080306 · Cited by 358 · see citing works
Neuroimaging and Neuropathological Studies of Mood Disorders
Drevets, W. C., & Price, J. L. (2005) · Biology of Depression · doi:10.1002/9783527619672.ch17 · Cited by 26 · see citing works
Choline acetyltransferase-containing neurons in the human parietal neocortex
Benagiano, V, Virgintino, D., Flace, P., Girolamo, F., Errede, M., & Roncali, L. (2009) · European Journal of Histochemistry · doi:10.4081/835 · Cited by 13 · see citing works
- Authors
- D'Amelio, F., Eng, L. F., & Gibbs, M. A.
- Affiliations
- Ames Research Center (US)
- Stanford Medicine (US)
- Corresponding author
- D'Amelio, Fernando
- Venue
- Glia
- Publisher
- Wiley
- Published
- 1990-01
- Volume
- 3
- Issue
- 5
- Pages
- 335-341
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W1992754936
- Cited by
- 101
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 2
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Glia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns011632-22)
- National Institute of Neurological Disorders and Stroke (NS-11632)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- glutamine synthetase, oligodendrocytes, oligodendroglia, central nervous system, cerebral cortex, cerebellum, brainstem, spinal cord, gray matter, white matter, myelination
- MeSH terms
- Animals, Brain Stem, Cats, Central Nervous System, Cerebellum, Cerebral Cortex, Glutamate-Ammonia Ligase, Immunohistochemistry, Neurons, Oligodendroglia, Spinal Cord
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
