The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Angiogenesis in malignant gliomas
Abstract
One event that accompanies glioma progression is the upregulation of angiogenesis. Low‐grade gliomas are moderately vascularized tumors whereas high‐grade gliomas show prominent microvascular proliferations and areas of high vascular density. To analyze the molecular mechanisms underlying glioma angiogenesis, we studied the expression of vascular endothelial growth factor (VEGF) and its tyrosine kinase receptors VEGFR‐1 and VEGFR‐2 during normal brain development and glioma‐induced angiogenesis. Our results suggest a paracrine control of angiogenesis and endothelial cell proliferation that is tightly regulated and transient in the embryonic brain, switched off in the normal adult brain, and turned on in tumor cells (VEGF) and the host vasculature (VEGFR‐1 and −2) during tumor progression. It is unknown how VEGF and VEGF receptors are upregulated during glioma angiogenesis, but there is recent evidence that VEGF as well as endogenous inhibitors of angiogenesis could be under control of the tumor suppressor genes p53 and VHL. © 1995 Wiley‐Liss, Inc.
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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617
Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S., & Ferrara, N. (1993) · Nature · doi:10.1038/362841a0 · Cited by 3,605
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
Houck, K. A., Leung, D. W., Rowland, A. M., Winer, J., & Ferrara, N. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35712-0 · Cited by 1,127
p53-Dependent apoptosis suppresses tumor growth and progression in vivo
Symonds, H., Krall, L., Remington, L., Saenz-Robles, M., Lowe, S., Jacks, T., & Van Dyke, T. (1994) · Cell · doi:10.1016/0092-8674(94)90534-7 · Cited by 880
Cited by
A survey of MRI-based medical image analysis for brain tumor studies
Bauer, S., Wiest, R., Nolte, L.-P., & Reyes, M. (2013) · Physics in Medicine and Biology · doi:10.1088/0031-9155/58/13/r97 · Cited by 1,036
The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis
Garkavtsev, I., Kozin, S. V., Chernova, O., Xu, L., Winkler, F., Brown, E., Barnett, G. H., & Jain, R. K. (2004) · Nature · doi:10.1038/nature02329 · Cited by 353
Cheng, S. Y., Huang, H. J., Nagane, M., Ji, X. D., Wang, D., Shih, C. C., Arap, W., Huang, C. M., & Cavenee, W. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8502 · Cited by 342
Schmidt, N. O., Westphal, M., Hagel, C., Erg�n, S., Stavrou, D., Rosen, E. M., & Lamszus, K. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990219)84:1<10::aid-ijc3>3.0.co;2-l · Cited by 296
Molecular Basis of Angiogenesis: Role of VEGF and VE‐Cadherin
CARMELIET, P., & COLLEN, D. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06320.x · Cited by 264
Metadata
- Authors
- Plate, K. H., & Risau, W.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 1995-11
- Volume
- 15
- Issue
- 3
- Pages
- 339-347
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W1984284981
- Cited by
- 337
- References
- 5
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
