The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Molecular Basis of Angiogenesis: Role of VEGF and VE‐Cadherin
Abstract
A bstract: The formation of new blood vessels (angiogenesis) is essential for embryonic development and contributes to the pathogenesis of numerous disorders. In contrast, insufficient angiogenesis may lead to tissue ischemia and failure. The recent discovery of novel angiogenic molecules has initiated efforts to improve tissue perfusion via therapeutic angiogenesis. However, rational design of such treatment strategies mandates a better understanding of the molecular mechanisms of angiogenesis. In this brief review, the role of a prime angiogenic candidate, namely vascular endothelial growth factor (VEGF) and its homologues, in physiological and pathological angiogenesis will be discussed with particular attention to myocardial ischemia and heart failure. In addition, a novel interaction between the junctional protein vascular endothelial‐cadherin (VE‐cadherin) and VEGF, essential for the endothelial survival function of VEGF, will be reviewed.
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Citations
Cites
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Cited by
Gavard, J., & Gutkind, J. S. (2006) · Nature Cell Biology · doi:10.1038/ncb1486 · Cited by 1,018
Osteogenesis and angiogenesis: The potential for engineering bone
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Development of the blood-brain barrier
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VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells
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Metadata
- Authors
- CARMELIET, P., & COLLEN, D.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2000-05
- Volume
- 902
- Issue
- 1
- Pages
- 249-264
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2170181331
- Cited by
- 264
- References
- 107
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- CARMELIET, P., & COLLEN, D. (2000). Molecular Basis of Angiogenesis: Role of VEGF and VE‐Cadherin. Annals of the New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.2000.tb06320.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
