Syndromes of behavioural and psychological symptoms in mild Alzheimer's disease
Abstract
Objectives: Behavioural and psychological symptoms of dementia (BPSD) are common in Alzheimer's disease (AD), and are associated with significant distress for patient and carer. Certain behavioural and psychological symptoms have been associated with each other, leading to the suggestion that differences in symptom patterns among patients with AD may represent different syndromes within AD. The purpose of this study is to see if patients with AD could be meaningfully classified into syndromes, based on the relationships between their BPSD. Methodology: The sample was recruited through a memory clinic. Two hundred and forty first visit patients with a diagnosis of very mild to mild AD were included. BPSD were assessed using the BEHAVE‐AD. Latent class analysis was used to assess for different classes or groups of patients within the sample, based on their behavioural and psychological symptoms. Results: Three classes were identified; Class 1 with a low prevalence of behavioural and psychological symptoms; Class 2 an anxiety/depressive symptom class and Class 3 an aggressive symptom class. Conclusions: The three classes (or groups) of patients obtained by LCA in this sample may be explained by a ‘latent’, as yet, unidentified factor. Further research is required to determine if these classes are stable over time, and to identify possible latent variables. Copyright © 2004 John Wiley & Sons, Ltd.
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Anxiety does not seem specific to a particular type of dementia.
“L'anxiété ne semble pas spécifique à un type particulier de démence.”
From Prise en charge des troubles anxieux dans le cadre d'atteintes neurologiques (2004) · cites this paper as [21]
Anxiety is frequent in Alzheimer's disease and frontotemporal dementia but can also be observed in Lewy body disease or non-degenerative dementias, notably vascular, infectious or inflammatory.
“Elle est fréquente dans la maladie d'Alzheimer et dans la démence fronto-temporale mais elle peut également s'observer dans la maladie à corps de Lewy ou dans les démences non dégénératives, notamment vasculaires, infectieuses ou inflammatoires [21].”
From Prise en charge des troubles anxieux dans le cadre d'atteintes neurologiques (2004) · cites this paper as [21]
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- Authors
- Moran, M., Walsh, C., Lynch, A., Coen, R. F., Coakley, D., & Lawlor, B. A.
- Affiliations
- St. James's Hospital (IE)
- Venue
- International Journal of Geriatric Psychiatry
- Publisher
- Wiley
- Published
- 2004-02-25
- Volume
- 19
- Issue
- 4
- Pages
- 359-364
- ISSN
- 0885-6230 (ISSN-L)
- 1099-1166
- OpenAlex
- W2018614199
- Cited by
- 56
- References
- 0
- Citations by year
- 2025: 1 · 2024: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 4
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- behavioral and psychological symptoms of dementia, mild Alzheimer's disease, latent class analysis, anxiety and depressive symptoms, aggression, BEHAVE-AD, symptom classification
- MeSH terms
- Aged, Aggression, Alzheimer Disease, Mental Disorders, Factor Analysis, Statistical, Female, Humans, Male, Psychiatric Status Rating Scales, Social Behavior Disorders, Syndrome, Geriatric Assessment
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