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Cited by 199Dementia and Cognitive Impairment ResearchIntensive Care Unit Cognitive DisordersWorkplace Violence and Bullying

Physical Aggression in Dementia Patients and Its Relationship to Depression

Lyketsos, Constantine G., Steele, Cynthia, Galik, Elizabeth, Rosenblatt, Adam, Steinberg, Martin, Warren, Andrew, Sheppard, Jeannie-Marie·1999·American Journal of Psychiatry
DOI 10.1176/ajp.156.1.66
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Abstract

OBJECTIVE: The goal of this study was to determine the frequency of physically aggressive behavior in community-residing patients with dementia and its relationship to depression. METHOD: A consecutive series of 541 patients with DSM-IV-defined dementia underwent comprehensive neuropsychiatric evaluation and were rated on the Cornell Scale for Depression in Dementia, the Mini-Mental State, the Psychogeriatric Dependency Rating Scale, and the General Medical Health Rating. RESULTS: Physically aggressive behavior was exhibited by 79 patients in the 2 weeks before evaluation. Aggressive behavior was closely associated with moderate to severe depression, male gender, and greater impairment in activities of daily living, even after adjustment for delusions, hallucinations, sleep disturbance, and severity of cognitive impairment. After adjustment for depression, gender, and impairment in activities of daily living, there was no association between physically aggressive behavior and the presence of either delusions or hallucinations. CONCLUSIONS: A substantial minority of patients with dementia exhibit physically aggressive behavior, and this aggression is strongly linked with the presence of depressive symptoms. It is possible that the identification and treatment of depression in dementia may be a means of preventing and managing physically aggressive behavior.

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  • Individuals with impaired physical functioning and with dementia and depression are at high risk for disturbing behaviors.

    “Individuals with impaired physical functioning 23-25 and with dementia and depression 20,26 are at high risk for disturbing behaviors”

    From Therapeutic recreation interventions for need-driven dementia-compromised (2002) · cites this paper as [20]

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Authors
Lyketsos, C. G., Steele, C., Galik, E., Rosenblatt, A., Steinberg, M., Warren, A., & Sheppard, J.-M.
Affiliations
Johns Hopkins University (US)
ORCID
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
1999-01-01
Volume
156
Issue
1
Pages
66-71
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/ajp.156.1.66
OpenAlex
W2106279983
Cited by
199
References
37
Citations by year
2026: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 9 · 2019: 4 · 2018: 7 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 8 · 2013: 3 · 2012: 10
FWCI
8.79
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh056511-05)
  • National Institute of Mental Health (MH56511)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
  • Social Sciences › Sociology and Political Science › Workplace Violence and Bullying
Keywords
physical aggression, dementia, depression, community-dwelling older adults, neuropsychiatric symptoms, activities of daily living, delusions, hallucinations, Cornell Scale for Depression in Dementia, gender differences
MeSH terms
Activities of Daily Living, Aged, Aggression, Cross-Sectional Studies, Delusions, Dementia, Depressive Disorder, Female, Hallucinations, Humans, Male, Neuropsychological Tests, Psychiatric Status Rating Scales, Severity of Illness Index, Sex Factors, Comorbidity

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