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Antidepressant drug prescribing among elderly subjects: a population-based study
Abstract
BACKGROUND: The patterns of antidepressant drug prescribing have rarely been studied in large and geographically defined populations of elderly subjects. In the present study we examined the prevalence and distribution of antidepressant prescribing in Lombardy, a northern Italy region with more than one and a half million elderly inhabitants. METHODS: We used the Regional Administrative Database of Lombardy. This database includes all prescriptions reimbursed by the National Health System in the population living in this region. All antidepressant prescriptions dispensed to subjects aged 65 years or above during 2001 were extracted and prevalence data calculated by dividing antidepressant users by the total number of male and female residents in each age group. RESULTS: During the 12 months surveyed 153,706 subjects were dispensed one or more prescriptions of antidepressants, yielding a prevalence of use of 9.49 subjects per 100 inhabitants (95% confidence interval 9.44, 9.53). Although the proportion of chronic users slightly decreased with age, more than 35% of those older that 85 years were moderate or chronic antidepressant users. General practitioners issued the majority of antidepressant prescriptions, and most antidepressant users were also dispensed agents for medical disorders. CONCLUSIONS: The very high rates of antidepressant drug prescribing detected in late life suggest the need of characterising these subjects in terms of medical and psychiatric characteristics, needs and quality of life. It also suggests the need for pragmatic clinical trials, carried out in the general practice, with the aim of assessing whether antidepressants are effective in these conditions.
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Psychotropic use has been shown to increase with age.
“Psychotropic use has been shown to increase with age [3, 4].”
From Stakeholders' views on the use of psychotropic medication in older people: a systematic review (2022) · cites this paper as [4]
The findings of this review help explain the findings of previous studies that have shown high rates of inappropriate psychotropic prescribing in older people both in care homes and wider settings.
“The findings of this review help explain the findings of previous studies that have shown high rates of inappropriate psychotropic prescribing in older people both in care homes [4–7] and wider settings [83].”
From Stakeholders' views on the use of psychotropic medication in older people: a systematic review (2022) · cites this paper as [4]
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Metadata
- Authors
- Percudani, M., Barbui, C., Fortino, I., & Petrovich, L.
- Affiliations
- Regione Lombardia (IT)
- University of Verona (IT)
- Corresponding author
- Percudani, Mauro
- Venue
- International Journal of Geriatric Psychiatry
- Publisher
- Wiley
- Published
- 2005-01-19
- Volume
- 20
- Issue
- 2
- Pages
- 113-118
- ISSN
- 0885-6230 (ISSN-L)
- 1099-1166
- OpenAlex
- W2119817792
- Cited by
- 50
- References
- 18
- Citations by year
- 2023: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2016: 2 · 2015: 5 · 2012: 3
- FWCI
- 10.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- antidepressant prescribing, older adults, general practitioners, prescribing patterns, Lombardy, geriatric depression
- MeSH terms
- Aged, Aged, 80 and over, Antidepressive Agents, Mental Disorders, Humans, Italy, Practice Patterns, Physicians', Quality of Life, Prevalence, Confidence Intervals, Databases, Factual
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