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Cited by 51Dementia and Cognitive Impairment ResearchCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatments

Detecting effects of donepezil on visual selective attention using signal detection parameters in Alzheimer's disease

Foldi, Nancy S., White, Richard E. C., Schaefer, Lynn A.·2005·International Journal of Geriatric Psychiatry
DOI 10.1002/gps.1319
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Abstract

Background: Attentional function is impaired in Alzheimer's disease (AD). Moreover, attention is mediated by acetylcholine. But, despite the widespread use of acetylcholinesterase inhibitors (AChE‐I) to augment available acetylcholine in AD, measures of attentional function have not been used to assess the drug response. Objectives: We hypothesized that as cholinergic augmentation impacts directly on the attentional system, higher‐order measures of visual selective attention would be sensitive to effects of treatment using an AChE‐I (donepezil hydrochloride). We also sought to determine whether these attentional measures were more sensitive to treatment than other measures of cognitive function. Methods: Seventeen patients with AD (8 untreated, 9 treated with donepezil) were contrasted on performance of a selective cancellation task. Two signal detection parameters were used as outcome measures: decision strategy (beta, β) and discriminability (d‐prime, d′). Standard screening and cognitive domain measures of vigilance, language, memory, and executive function were also contrasted. Results: Treated patients judged stimuli more conservatively (p = 0.29) by correctly endorsing targets and rejecting false alarms. They also discriminated targets from distractors more easily (p = 0.58). The screening and neuropsychological measures failed to differentiate the groups. Conclusions: Higher‐order attentional measures captured the effects of donepezil treatment in small groups of patients with AD. The results suggest that cholinergic availability may directly affect the attentional system, and that these selective attention measures are sensitive markers to detect treatment response. Copyright © 2005 John Wiley & Sons, Ltd.

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  • A relatively small number of studies reported that AChE inhibitors produce small yet significant enhancement of cognitive, specifically attentional functions in patients with Alzheimer's disease.

    “Moreover, a relatively small number of studies reported that AChE inhibitors produce small yet significant enhancement of cognitive, specifically attentional functions in patients with Alzheimer’s disease (e.g., Sahakian et al, 1993; Foldi et al, 2005).”

    From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Foldi et al, 2005

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Authors
Foldi, N. S., White, R. E. C., & Schaefer, L. A.
Affiliations
Queens College, CUNY (US)
Corresponding author
Foldi, Nancy S.
ORCID
Venue
International Journal of Geriatric Psychiatry
Publisher
Wiley
Published
2005-04-25
Volume
20
Issue
5
Pages
485-488
ISSN
  • 0885-6230 (ISSN-L)
  • 1099-1166
DOI
10.1002/gps.1319
OpenAlex
W1965653086
Cited by
51
References
21
Citations by year
2026: 1 · 2021: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 7 · 2014: 4 · 2013: 4 · 2012: 2
FWCI
2.41
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • International Journal of Geriatric Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
donepezil, Alzheimer's disease, visual selective attention, acetylcholinesterase inhibitors, signal detection theory, d-prime, decision strategies, treatment response monitoring, attention function
MeSH terms
Donepezil, Aged, Alzheimer Disease, Attention, Cholinesterase Inhibitors, Cognition, Decision Making, Discrimination, Psychological, Female, Humans, Indans, Male, Neuropsychological Tests, Pattern Recognition, Visual, Photic Stimulation, Piperidines, Signal Detection, Psychological

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