The septo-hippocampal system, learning and recovery of function

Niewiadomska, Grazyna; Baksalerska-Pazera, Marta; Riedel, Gernot

doi:10.1016/j.pnpbp.2009.03.039

Cited by 67Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchCholinesterase and Neurodegenerative Diseases

The septo-hippocampal system, learning and recovery of function

Niewiadomska, Grazyna, Baksalerska-Pazera, Marta, Riedel, Gernot·2009·Progress in Neuro-Psychopharmacology and Biological Psychiatry

DOI 10.1016/j.pnpbp.2009.03.039

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Abstract

We understand this review as an attempt to summarize recent advances in the understanding of cholinergic function in cognition. Such a role has been highlighted in the 1970s by the discovery that dementia patients have greatly reduced cholinergic activity in cortex and hippocampus. A brief anatomical description of the major cholinergic pathways focuses on the basal forebrain and its projections to cortex and hippocampus. From this distinction, compelling evidence suggests that the basal forebrain --> cortex projection regulates the excitability of principal cortical neurons and is thereby critically involved in attention, stimulus detection and memory function, although the biological conditions for these functions are still debated. Similar uncertainties remain for the septo-hippocampal cholinergic system. Although initial lesions of the septum caused memory deficits reminiscent of hippocampal ablations, recent and more refined neurotoxic lesion studies which spared non-cholinergic cells of the basal forebrain failed to confirm these memory impairments in experimental animals despite a near total loss of cholinergic labeling. Yet, a decline in cholinergic markers in aging and dementia still stands as the most central piece of evidence for a link between the cholinergic system and cognition and appear to provide valuable targets for therapeutic approaches.

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Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress
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Authors: Niewiadomska, G., Baksalerska-Pazera, M., & Riedel, G.
Affiliations: Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
University of Aberdeen (GB)
ORCID: Riedel, Gernot
Venue: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher: Elsevier BV
Published: 2009-08
Volume: 33
Issue: 5
Pages: 791-805
ISSN: 0278-5846 (ISSN-L)
DOI: 10.1016/j.pnpbp.2009.03.039
OpenAlex: W1979648372
Cited by: 67
References: 325
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 6 · 2013: 7 · 2012: 9
FWCI: 3.06
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Keywords: memory impairment, septal lesions, hippocampal ablation, cortical excitability, attention, stimulus detection, dementia, aging, cholinergic markers, functional recovery, learning
MeSH terms: Animals, Cognition Disorders, Hippocampus, Humans, Learning, Nerve Net, Recovery of Function, Septum of Brain

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The septo-hippocampal system, learning and recovery of function

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