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Cited by 106Chronic Obstructive Pulmonary Disease (COPD) ResearchMental Health Treatment and AccessAging, Health, and Disability

Prevalence of sub-threshold depression in elderly patients with chronic obstructive pulmonary disease

Yohannes, Abebaw M., Baldwin, Robert C., Connolly, Martin J.·2003·International Journal of Geriatric Psychiatry
DOI 10.1002/gps.851
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Abstract

OBJECTIVES: We hypothesized that COPD patients with sub-threshold depression would have levels of disability and impaired quality of life approaching that for major depression and significantly greater than for non-depressed COPD patients. SETTING: A university teaching hospital METHOD: 137 outpatients (69 men), with a mean age of 73 years (range 60-89 years) with symptomatic irreversible, moderate to severe COPD were recruited. Subjects were interviewed using the Geriatric Mental State Schedule (GMS), a structured psychiatric interview schedule, along with its diagnostic algorithm AGECAT. A GMS/AGECAT score of 3 or more is indicative of a case-level of depression, a GMS/AGECAT score of 1-2 indicates sub-threshold depression and GMS/AGECAT of 0, no depression. Physical disability was measured by the Manchester Respiratory Activities of Daily Living questionnaire (MRADL) and quality of life was assessed by the Breathing Problems Questionnaire (BPQ). RESULTS: Mean (SD) one second forced expiratory volume was 0.89 (0.33) litres. The prevalence of GMS/AGECAT case-level depression (>or= 3) was 57 cases (42%); of GMS/AGECAT sub-threshold depression (1-2) 34 (25%); and GMS/AGECAT non-depression (0) 46 (33%). Comparison of MRADL score in the three groups (mean, 95% confidence intervals) revealed [GMS >or= 3 = 9.9 (8.4 to 11.3) vs GMS = 1-2, 12.9 (11.2 to 14.4) vs GMS = 0, 15.6 (14 to 16.6) p < 0.0001]. BPQ scores (mean, 95% confidence intervals) showed [GMS >or= 3 = 54 (50 to 57) vs GMS = 1-2, 40 (36.3 to 44) GMS = 0, 33 (30.6 to 36.7) p < 0.0001]. There was no significant difference in FEV(1) between the three groups. CONCLUSION: Sub-threshold depression accounted for 25% of the sample. In this study disability associated with sub-threshold depression in patients with COPD was intermediate to that associated with case-level depression and no with depression and significantly worse than in the latter group. Sub-threshold depression is associated with substantial morbidity in COPD.

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  • Approximately one fourth of COPD patients have unrecognized subclinical depression.

    “In one study,34 it was reported that approximately one fourth of COPD patients had unrecognized subclinical depression.”

    From Anxiety and Depression in COPD (2008) · cites this paper as [34]

  • Lack of treatment for depression and anxiety is associated with poor quality of life and premature death.

    “Lack of treatment is also associated with poor quality of life and premature death.26,34–36”

    From Anxiety and Depression in COPD (2008) · cites this paper as [34]

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Authors
Yohannes, A. M., Baldwin, R. C., & Connolly, M. J.
Affiliations
Manchester Royal Infirmary (GB)
Corresponding author
Yohannes, Abebaw M.
ORCID
Venue
International Journal of Geriatric Psychiatry
Publisher
Wiley
Published
2003-04-09
Volume
18
Issue
5
Pages
412-416
ISSN
  • 0885-6230 (ISSN-L)
  • 1099-1166
DOI
10.1002/gps.851
OpenAlex
W2159668364
Cited by
106
References
21
Citations by year
2026: 3 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 1 · 2013: 7 · 2012: 8
FWCI
6.24
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • International Journal of Geriatric Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • e-space (Manchester Metropolitan University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Keywords
depression, subthreshold depression, chronic obstructive pulmonary disease, elderly patients, physical disability, quality of life, depression prevalence, FEV1, activities of daily living, geriatric depression screening, COPD exacerbation risk, mortality risk, hospitalization risk, comorbidities
MeSH terms
Aged, Aged, 80 and over, Depressive Disorder, Female, Forced Expiratory Volume, Humans, Male, Middle Aged, Quality of Life, Single-Blind Method, Pulmonary Disease, Chronic Obstructive

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