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Effects of acute dehydration on brain morphology in healthy humans
Abstract
Dehydration can affect brain structure which has important implications for human health. In this study, we measured regional changes in brain structure following acute dehydration. Healthy volunteers received a structural MRI scan before and after an intensive 90‐min thermal‐exercise dehydration protocol. We used two techniques to determine changes in brain structure: a manual point counting technique using MEASURE, and a fully automated voxelwise analysis using SIENA. After the exercise regime, participants lost (2.2% ± 0.5%) of their body mass. Using SIENA, we detected expansion of the ventricular system with the largest change occurring in the left lateral ventricle (P = 0.001 corrected for multiple comparisons) but no change in total brain volume (P = 0.13). Using manual point counting, we could not detect any change in ventricular or brain volume, but there was a significant correlation between loss in body mass and third ventricular volume increase (r = 0.79, P = 0.03). These results show ventricular expansion occurs following acute dehydration, and suggest that automated longitudinal voxelwise analysis methods such as SIENA are more sensitive to regional changes in brain volume over time compared with a manual point counting technique. Hum Brain Mapp 2009. © 2007 Wiley‐Liss, Inc.
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“However, a consistent effect of hypohydration on these measures of brain function [147–153] at the levels of BML typically reported in the cognition literature (e.g., 1–4% BML in team sport studies) has not been found.”
From Fluid Balance in Team Sport Athletes and the Effect of Hypohydration on Cognitive, Technical, and Physical Performance (2017) · cites this paper as [149]
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Dehydration confounds the assessment of brain atrophy
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Cited by
Head motion during MRI acquisition reduces gray matter volume and thickness estimates
Reuter, M., Tisdall, M. D., Qureshi, A., Buckner, R. L., van der Kouwe, A. J. W., & Fischl, B. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2014.12.006 · Cited by 457
Dehydration: Physiology, Assessment, and Performance Effects
Cheuvront, S. N., & Kenefick, R. W. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c130017 · Cited by 461
Nuccio, R. P., Barnes, K. A., Carter, J. M., & Baker, L. B. (2017) · Sports Medicine · doi:10.1007/s40279-017-0738-7 · Cited by 252
Hypohydration and human performance: Impact of environment and physiological mechanisms
Sawka, M. N., Cheuvront, S. N., & Kenefick, R. W. (2015) · Sports Medicine · doi:10.1007/s40279-015-0395-7 · Cited by 236
Dehydration affects brain structure and function in healthy adolescents
Kempton, M. J., Ettinger, U., Foster, R., Williams, S. C. R., Calvert, G. A., Hampshire, A., Zelaya, F. O., O'Gorman, R. L., McMorris, T., Owen, A. M., et al. (2011) · Human Brain Mapping · doi:10.1002/hbm.20999 · Cited by 178
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Metadata
- Authors
- Kempton, M. J., Ettinger, U., Schmechtig, A., Winter, E. M., Smith, L., McMorris, T., Wilkinson, I. D., Williams, S. C. R., & Smith, M. S.
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2007-12-06
- Volume
- 30
- Issue
- 1
- Pages
- 291-298
- ISSN
- 1065-9471
- 1097-0193
- Cited by
- 101
- References
- 1
- Language
- en
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