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Resting state sensorimotor functional connectivity in multiple sclerosis inversely correlates with transcallosal motor pathway transverse diffusivity
Open accessAbstract
Recent studies indicate that functional connectivity using low‐frequency BOLD fluctuations (LFBFs) is reduced between the bilateral primary sensorimotor regions in multiple sclerosis. In addition, it has been shown that pathway‐dependent measures of the transverse diffusivity of water in white matter correlate with related clinical measures of functional deficit in multiple sclerosis. Taken together, these methods suggest that MRI methods can be used to probe both functional connectivity and anatomic connectivity in subjects with known white matter impairment. We report the results of a study comparing anatomic connectivity of the transcallosal motor pathway, as measured with diffusion tensor imaging (DTI) and functional connectivity of the bilateral primary sensorimotor cortices (SMC), as measured with LFBFs in the resting state. High angular resolution diffusion imaging was combined with functional MRI to define the transcallosal white matter pathway connecting the bilateral primary SMC. Maps were generated from the probabilistic tracking employed and these maps were used to calculate the mean pathway diffusion measures fractional anisotropy 〈FA〉, mean diffusivity 〈MD〉, longitudinal diffusivity 〈λ 1〉, and transverse diffusivity 〈λ 2〉. These were compared with LFBF‐based functional connectivity measures (Fc) obtained at rest in a cohort of 11 multiple sclerosis patients and ∼10 age‐ and gender‐matched control subjects. The correlation between 〈FA〉 and Fc for MS patients was r = −0.63, P < 0.04. The correlation between all subjects 〈λ 2〉 and Fc was r = 0.42, P < 0.05. The correlation between all subjects 〈λ 2〉 and Fc was r = −0.50, P < 0.02. None of the control subject correlations were significant, nor were 〈FA〉, 〈λ 1〉, or 〈MD〉 significantly correlated with Fc for MS patients. This constitutes the first in vivo observation of a correlation between measures of anatomic connectivity and functional connectivity using spontaneous LFBFs. Hum Brain Mapp, 2008. © 2008 Wiley‐Liss, Inc.
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“higher FA has been associated with better functional connectivity between anatomically distant gray matter regions using resting-state fMRI (functional MRI) 35,47,48”
From Physical exercise keeps the brain connected: biking increases white matter integrity in patients with schizophrenia and healthy controls. (2015) · cites this paper as [48]
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Metadata
- Authors
- Lowe, M. J., Beall, E. B., Sakaie, K. E., Koenig, K. A., Stone, L., Marrie, R. A., & Phillips, M. D.
- Affiliations
- Cleveland Clinic (US)
- University of Manitoba (CA)
- ORCID
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2008-04-25
- Volume
- 29
- Issue
- 7
- Pages
- 818-827
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6871176
- OpenAlex
- W2022349962
- Cited by
- 196
- References
- 69
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 12 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 10 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 12 · 2015: 10 · 2014: 13 · 2013: 21 · 2012: 18
- FWCI
- 15.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- multiple sclerosis, resting-state functional connectivity, sensorimotor cortex, fractional anisotropy, mean diffusivity, white matter connectivity, probabilistic tractography, high angular resolution diffusion imaging
- MeSH terms
- Brain Mapping, Corpus Callosum, Efferent Pathways, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Motor Cortex, Multiple Sclerosis
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