The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Test-retest reproducibility of the default-mode network in healthy individuals
Open accessAbstract
Independent component analysis (ICA) of functional magnetic resonance imaging (fMRI) time-series reveals distinct coactivation patterns in the resting brain representing spatially coherent spontaneous fluctuations of the fMRI signal. Among these patterns, the so-called default-mode network (DMN) has been attributed to the ongoing mental activity of the brain during wakeful resting state. Studies suggest that many neuropsychiatric diseases disconnect brain areas belonging to the DMN. The potential use of the DMN as functional imaging marker for individuals at risk for these diseases, however, requires that the components of the DMN are reproducible over time in healthy individuals. In this study, we assessed the reproducibility of the DMN components within and between imaging sessions in 18 healthy young subjects (mean age, 27.5 years) who were scanned three times with two resting state scans during each session at 3.0 T field strength. Statistical analysis of fMRI time-series was done using ICA implemented with BrainVoyager QX. At all three sessions the essential components of the DMN could be identified in each individual. Spatial extent of DMN activity and size of overlap within and between sessions were most reproducible for the anterior and posterior cingulate gyrus. The degree of reproducibility of the DMN agrees with the degree of reproducibility found with motor paradigms. We conclude that DMN coactivation patterns are reproducible in healthy young subjects. Therefore, these data can serve as basis to further explore the effects of aging and neuropsychiatric diseases on the DMN of the brain.
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“Several recent studies of testretest reproducibility for time-concatenated ICA (i.e., our ICA method in this study) of resting state fMRI, however, indicate very good reproducibility when the resting state sessions are performed within one year of each other [Guo et al., 2012;Meindl et al., 2010;Zuo et al., 2010].”
From Specific default mode subnetworks support mentalizing as revealed through opposing network recruitment by social and semantic FMRI tasks: Mentalizing and Default-Mode Subnetworks (2015) · cites this paper as Meindl et al., 2010
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Metadata
- Authors
- Meindl, T., Teipel, S., Elmouden, R., Mueller, S., Koch, W., Dietrich, O., Coates, U., Reiser, M., & Glaser, C.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- University of Rostock (DE)
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2009-07-20
- Volume
- 31
- Issue
- 2
- Pages
- 237-246
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6871144
- OpenAlex
- W2082137112
- Cited by
- 220
- References
- 35
- Citations by year
- 2026: 3 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 17 · 2020: 7 · 2019: 33 · 2018: 4 · 2017: 18 · 2016: 8 · 2015: 12 · 2014: 23 · 2013: 18 · 2012: 22
- FWCI
- 10.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Human Brain Mapping (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Keywords
- default mode network, test-retest reproducibility, resting-state fMRI, independent component analysis, spontaneous brain activity, anterior cingulate cortex, posterior cingulate cortex, healthy young adults
- MeSH terms
- Adult, Brain, Brain Mapping, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Motor Activity, Neural Pathways, Neuropsychological Tests, Signal Processing, Computer-Assisted, Software, Reproducibility of Results, Young Adult
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