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Cited by 96Neural dynamics and brain functionFunctional Brain Connectivity StudiesNicotinic Acetylcholine Receptors Study

From eyes‐closed to eyes‐open: Role of cholinergic projections in EC‐to‐EO alpha reactivity revealed by combining EEG and MRI

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Wan, Lu, Huang, Haiqing, Schwab, Nadine, Tanner, Jared, Rajan, Abhijit, Lam, Ngoc B., Zaborszky, Laszlo, Li, Chiang‐shan R. +2 more·2019·Human Brain Mapping
DOI 10.1002/hbm.24395PMC PMC6338213
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Abstract

Alpha rhythm (8 to 12 Hz) observed in EEG over human posterior cortex is prominent during eyes‐closed (EC) resting and attenuates during eyes‐open (EO) resting. Research shows that the degree of EC‐to‐EO alpha blocking or alpha desynchronization, termed alpha reactivity here, is a neural marker of cognitive health. We tested the role of acetylcholine in EC‐to‐EO alpha reactivity by applying a multimodal neuroimaging approach to a cohort of young adults and a cohort of older adults. In the young cohort, simultaneous EEG‐fMRI was recorded from twenty‐one young adults during both EO and EC resting. In the older cohort, functional MRI was recorded from forty older adults during EO and EC resting, along with FLAIR and diffusion MRI. For a subset of twenty older adults, EEG was recorded during EO and EC resting in a separate session. In both young and older adults, functional connectivity between the basal nucleus of Meynert (BNM), the major source of cortical acetylcholine, and the visual cortex increased from EC to EO, and this connectivity increase was positively associated with alpha reactivity; namely, the stronger the BNM‐visual cortex functional connectivity increase from EC to EO, the larger the EC‐to‐EO alpha desynchronization. In older adults, lesions of the fiber tracts linking BNM and visual cortex quantified by leukoaraiosis volume, associated with reduced alpha reactivity. These findings support a role of acetylcholine and particularly cholinergic pathways in mediating EC‐to‐EO alpha reactivity and suggest that impaired alpha reactivity could serve as a marker of the integrity of the cholinergic system.

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  • For both ST-GCN and T-CNN, classification accuracy in the EC state is higher than the corresponding EO state for all frequency bands and adjacency matrix calculation methods.

    “For both methods, the classification accuracy of all frequency bands and adjacency matrix calculation methods in the EC state is higher than the corresponding EO state, which is consistent with previous research results (Barry et al., 2007; Wan et al., 2019).”

    From <scp>Spatial–temporal</scp> graph convolutional network for Alzheimer classification based on brain functional connectivity imaging of electroencephalogram (2022) · cites this paper as Wan et al., 2019

    The Results (Young Dataset and Old Dataset; page not available) report higher EEG alpha power with eyes closed than with eyes open, supporting a limited EC–EO comparison. They do not report classification accuracy for ST-GCN or T-CNN, or comparisons across all frequency bands and adjacency-matrix methods. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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Cited by

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Authors
Wan, L., Huang, H., Schwab, N., Tanner, J., Rajan, A., Lam, N. B., Zaborszky, L., Li, C. R., Price, C. C., & Ding, M.
Affiliations
  • University of Florida (US)
  • University of Pittsburgh (US)
  • University of Florida Health (US)
  • Center for Molecular and Behavioral Neuroscience Rutgers University Newark New Jersey
  • Yale University (US)
Corresponding author
Ding, Mingzhou
ORCID
Venue
Human Brain Mapping
Publisher
Wiley
Published
2018-09-25
Volume
40
Issue
2
Pages
566-577
ISSN
  • 1065-9471 (ISSN-L)
  • 1097-0193
DOI
10.1002/hbm.24395
PMC
PMC6338213
OpenAlex
W2892816799
Cited by
96
References
3
Citations by year
2026: 11 · 2025: 14 · 2024: 14 · 2023: 10 · 2022: 10 · 2021: 18 · 2020: 14 · 2019: 4 · 2018: 1
FWCI
5.51
Type
journal article
Language
en
Open access
Licence
Locations
  • Human Brain Mapping (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation (BCS‐1344285)
  • National Institutes of Health (R01 MH117991, R01 NR014810, R01 NS082386, R01 NR014181)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
alpha desynchronization, acetylcholine, cholinergic projections, nucleus basalis of Meynert, visual cortex, functional connectivity, resting-state EEG, white matter hyperintensities, white matter integrity, aging, simultaneous EEG-fMRI
MeSH terms
Acetylcholine, Adult, Alpha Rhythm, Cortical Synchronization, Electroencephalography, Eye Movements, Female, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Visual Cortex, Signal Transduction, Biomarkers, Basal Nucleus of Meynert, Leukoaraiosis, Young Adult, Functional Neuroimaging

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