Cholinergic Enhancement Reduces Spatial Spread of Visual Responses in Human Early Visual Cortex
Open accessAbstract
Animal studies have shown that acetylcholine decreases excitatory receptive field size and spread of excitation in early visual cortex. These effects are thought to be due to facilitation of thalamocortical synaptic transmission and/or suppression of intracortical connections. We have used functional magnetic resonance imaging (fMRI) to measure the spatial spread of responses to visual stimulation in human early visual cortex. The cholinesterase inhibitor donepezil was administered to normal healthy human subjects to increase synaptic levels of acetylcholine in the brain. Cholinergic enhancement with donepezil decreased the spatial spread of excitatory fMRI responses in visual cortex, consistent with a role of acetylcholine in reducing excitatory receptive field size of cortical neurons. Donepezil also reduced response amplitude in visual cortex, but the cholinergic effects on spatial spread were not a direct result of reduced amplitude. These findings demonstrate that acetylcholine regulates spatial integration in human visual cortex.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Enhanced attention to stimuli is a key mechanism contributing to the effects of physostigmine on encoding, mediated by frontoparietal as well as sensory and sensory-associational areas.
“Furthermore, several studies identified enhanced attention to stimuli as a key mechanism that contributes to the effects of physostigmine on encoding, and determined that frontoparietal as well sensory and sensory-associational areas mediate these effects (e.g., Bentley et al, 2003, 2008; Furey et al, 2008; Silver et al, 2008).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Silver et al, 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Brainard, D. H. (1997) · Spatial Vision · doi:10.1163/156856897x00357 · Cited by 19,308 · see citing works
Jenkinson, M., Bannister, P., Brady, M., & Smith, S. (2002) · NeuroImage · doi:10.1006/nimg.2002.1132 · Cited by 11,888 · see citing works
The VideoToolbox software for visual psychophysics: transforming numbers into movies
Pelli, D. G. (1997) · Spatial Vision · doi:10.1163/156856897x00366 · Cited by 11,110 · see citing works
Neurophysiological investigation of the basis of the fMRI signal
Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., & Oeltermann, A. (2001) · Nature · doi:10.1038/35084005 · Cited by 6,542 · see citing works
Borders of Multiple Visual Areas in Humans Revealed by Functional Magnetic Resonance Imaging
Sereno, M. I., Dale, A. M., Reppas, J. B., Kwong, K. K., Belliveau, J. W., Brady, T. J., Rosen, B. R., & Tootell, R. B. H. (1995) · Science · doi:10.1126/science.7754376 · Cited by 2,658 · see citing works
RECEPTIVE FIELDS AND FUNCTIONAL ARCHITECTURE IN TWO NONSTRIATE VISUAL AREAS (18 AND 19) OF THE CAT
Hubel, D. H., & Wiesel, T. N. (1965) · Journal of Neurophysiology · doi:10.1152/jn.1965.28.2.229 · Cited by 2,615 · see citing works
Hartigan, J. A., & Hartigan, P. M. (1985) · The Annals of Statistics · doi:10.1214/aos/1176346577 · Cited by 1,996 · see citing works
The role of acetylcholine in learning and memory
Hasselmo, M. E. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.09.002 · Cited by 1,693 · see citing works
Retinotopic organization in human visual cortex and the spatial precision of functional MRI
Engel, S. A. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.2.181 · Cited by 1,606 · see citing works
Mapping striate and extrastriate visual areas in human cerebral cortex.
DeYoe, E. A., Carman, G. J., Bandettini, P. A., Glickman, S., Wieser, J., Cox, R. W., Miller, D. A., & Jay Neitz, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2382 · Cited by 1,047 · see citing works
Engel, S. A., Rumelhart, D. E., Wandell, B. A., Lee, A. T.-J., Glover, G. H., Chichilnisky, E. J., & Shadlen, M. N. (1994) · Nature · doi:10.1038/369525a0 · Cited by 977 · see citing works
Crowding—An essential bottleneck for object recognition: A mini-review
Levi, D. M. (2008) · Vision Research · doi:10.1016/j.visres.2007.12.009 · Cited by 976 · see citing works
Levey, A. I., Kitt, C. A., Wf, S., Price, D., & Brann, M. R. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-10-03218.1991 · Cited by 920 · see citing works
Shmuel, A., Augath, M., Oeltermann, A., & Logothetis, N. K. (2006) · Nature Neuroscience · doi:10.1038/nn1675 · Cited by 898 · see citing works
Circuits for local and global signal integration in primary visual cortex
Angelucci, A., Levitt, J. B., Walton, E. J. S., Hupé, J.-M., Bullier, J., & Lund, J. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08633.2002 · Cited by 789 · see citing works
Nature and Interaction of Signals From the Receptive Field Center and Surround in Macaque V1 Neurons
Cavanaugh, J. R., Bair, W., & Movshon, J. A. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00692.2001 · Cited by 784 · see citing works
Empirical Analyses of BOLD fMRI Statistics
Zarahn, E., Aguirre, G. K., & D’Esposito, M. (1997) · NeuroImage · doi:10.1006/nimg.1997.0263 · Cited by 695 · see citing works
Self-citationSarter, M., Hasselmo, M. E., Bruno, J. P., & Givens, B. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.08.006 · Cited by 667 · see citing works
Shmuel, A., Yacoub, E. S., Pfeuffer, J., de Moortele, P. V., Adriany, G., Hu, X. P., & Uǧurbil, K. (2002) · Neuron · doi:10.1016/s0896-6273(02)01061-9 · Cited by 621 · see citing works
Contrast's effect on spatial summation by macaque V1 neurons
Sceniak, M. P., Ringach, D. L., Hawken, M. J., & Shapley, R. M. (1999) · Nature Neuroscience · doi:10.1038/11197 · Cited by 608 · see citing works
Differential regulation of neocortical synapses by neuromodulators and activity
Gil, Z., Connors, B. W., & Amitai, Y. (1997) · Neuron · doi:10.1016/s0896-6273(00)80380-3 · Cited by 553 · see citing works
Hasselmo, M. E., & McGaughy, J. (2004) · Progress in Brain Research · doi:10.1016/s0079-6123(03)45015-2 · Cited by 525 · see citing works
Topographic Maps of Visual Spatial Attention in Human Parietal Cortex
Silver, M. A., Ress, D. B., & Heeger, D. J. (2005) · Journal of Neurophysiology · doi:10.1152/jn.01316.2004 · Cited by 482 · see citing works
Self-citationLength and width tuning of neurons in the cat's primary visual cortex
DeAngelis, G. C., Freeman, R. D., & Ohzawa, I. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.71.1.347 · Cited by 475 · see citing works
Angelucci, A., & Bressloff, P. C. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)54005-1 · Cited by 453 · see citing works
Cholinergic modulation of the functional organization of the cat visual cortex
Sillito, A. M., & Kemp, J. A. (1983) · Brain Research · doi:10.1016/0006-8993(83)90015-x · Cited by 387 · see citing works
Hasselmo, M. E., & Bower, J. M. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.67.5.1222 · Cited by 358 · see citing works
Gain Modulation by Nicotine in Macaque V1
Disney, A. A., Aoki, C., & Hawken, M. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.034 · Cited by 331 · see citing works
Investigation of Low Frequency Drift in fMRI Signal
Smith, A. M., Lewis, B. K., Ruttimann, U. E., Ye, F. Q., Sinnwell, T., Yang, Y., Duyn, J. H., & Frank, J. A. (1999) · NeuroImage · doi:10.1006/nimg.1999.0435 · Cited by 313 · see citing works
Cholinergic Enhancement and Increased Selectivity of Perceptual Processing During Working Memory
Furey, M. L., Pietrini, P., & Haxby, J. V. (2000) · Science · doi:10.1126/science.290.5500.2315 · Cited by 308 · see citing works
The representation of the ipsilateral visual field in human cerebral cortex
Tootell, R. B. H., Mendola, J. D., Hadjikhani, N. K., Liu, A. K., & Dale, A. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.818 · Cited by 244 · see citing works
A functional role of cholinergic innervation to neurons in the cat visual cortex
Sato, H., Hata, Y., Masui, H., & Tsumoto, T. (1987) · Journal of Neurophysiology · doi:10.1152/jn.1987.58.4.765 · Cited by 228 · see citing works
Stimulation of the nucleus basalis of Meynert increases cerebral cortical blood flow in rats
Biesold, D., Inanami, O., Sato, A., & Sato, Y. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90370-4 · Cited by 223 · see citing works
Attentional suppression of activity in the human visual cortex
Smith, A. T., Singh, K. D., & Greenlee, M. W. (2000) · Neuroreport · doi:10.1097/00001756-200002070-00010 · Cited by 220 · see citing works
On the classification of simple and complex cells
Mechler, F., & Ringach, D. L. (2002) · Vision Research · doi:10.1016/s0042-6989(02)00025-1 · Cited by 213 · see citing works
The cholinergic innervation of the human cerebral cortex.
Mesulam, M.-M. (2004) · Progress in Brain Research · doi:10.1016/s0079-6123(03)45004-8 · Cited by 211 · see citing works
Functional MRI detection of pharmacologically induced memory impairment
Sperling, R. A., Greve, D. N., Dale, A. M., Killiany, R., Holmes, J., Rosas, H. D., Cocchiarella, A. J., Firth, P. G., Rosen, B. R., Lake, S. L., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012467899 · Cited by 210 · see citing works
Metherate, R., & Ashe, J. H. (1993) · Synapse · doi:10.1002/syn.890140206 · Cited by 203 · see citing works
Bentley, P., Masud Husain, B., & Dolan, R. J. (2004) · Neuron · doi:10.1016/s0896-6273(04)00145-x · Cited by 179 · see citing works
Negative BOLD in the visual cortex: Evidence against blood stealing
Smith, A. T., Williams, A. L., & Singh, K. D. (2004) · Human Brain Mapping · doi:10.1002/hbm.20017 · Cited by 174 · see citing works
Pharmacokinetic and pharmacodynamic profile of donepezil HCl following multiple oral doses
Rogers, Cooper, Sukovaty, Pederson, Lee, & Friedhoff (1998) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1998.0460s1007.x · Cited by 171 · see citing works
Nicotinic control of axon excitability regulates thalamocortical transmission
Kawai, H., Lazar, R., & Metherate, R. (2007) · Nature Neuroscience · doi:10.1038/nn1956 · Cited by 171 · cited 2× · see citing works
“…on thalamocortical afferents in layer IV (Prusky et al., 1987; Disney et al., 2007), muscarinic receptors on cortical neurons (Levey et al., 1991), or nicotinic receptors on thalamocortical axons (located on the portion of the axon proximal to the presynaptic terminals) (Kawai et al., 2007).”
BackgroundKimura, F., Fukuda, M., & Tsumoto, T. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00779.x · Cited by 165 · see citing works
Hsieh, C. Y., Cruikshank, S. J., & Metherate, R. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02766-9 · Cited by 165 · see citing works
Giocomo, L. M., & Hasselmo, M. E. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-0032-z · Cited by 161 · see citing works
Pharmacokinetic and pharmacodynamic profile of donepezil HCl following single oral doses
Rogers, & Friedhoff (1998) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1998.0460s1001.x · Cited by 140 · see citing works
Attention alters spatial integration in macaque V1 in an eccentricity-dependent manner
Roberts, M. J., Delicato, L. S., Herrero, J. L., Gieselmann, M. A., & Thiele, A. (2007) · Nature Neuroscience · doi:10.1038/nn1967 · Cited by 133 · see citing works
Schon, K., Atri, A., Hasselmo, M. E., Tricarico, M. D., LoPresti, M. L., & Stern, C. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1982-05.2005 · Cited by 132 · see citing works
Cholinergic enhancement of direction selectivity in the visual cortex of the cat
Murphy, P. C., & Sillito, A. M. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90170-s · Cited by 130 · see citing works
Acetylcholine Dynamically Controls Spatial Integration in Marmoset Primary Visual Cortex
Roberts, M. J., Zinke, W., Guo, K., Robertson, R., McDonald, J. S., & Thiele, A. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00911.2004 · Cited by 127 · see citing works
Spatial relationship between neuronal activity and BOLD functional MRI
Kim, D., Ronen, I., Olman, C. A., Kim, S., Uǧurbil, K., & Toth, L. J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.10.018 · Cited by 124 · see citing works
Oldford, E., & Castro‐Alamancos, M. A. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00663-2 · Cited by 117 · see citing works
Bentley, P., Driver, J., & Dolan, R. J. (2007) · Brain · doi:10.1093/brain/awm299 · Cited by 115 · see citing works
Response Facilitation From the “Suppressive” Receptive Field Surround of Macaque V1 Neurons
Ichida, J. M., Schwabe, L., Bressloff, P. C., & Angelucci, A. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00298.2007 · Cited by 98 · see citing works
Zinke, W., Roberts, M. J., Guo, K., McDonald, J. S., Robertson, R., & Thiele, A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04882.x · Cited by 96 · see citing works
Cerebral effects of nicotine during cognition in smokers and non-smokers
Ghatan, P. H., Ingvar, M., Eriksson, L., Stone‐Elander, S., Serrander, M., Ekberg, K., & Wahren, J. (1998) · Psychopharmacology · doi:10.1007/s002130050554 · Cited by 94 · see citing works
Functional MRI of Human Brain during Breath Holding by BOLD and FAIR Techniques
Li, T., Kastrup, A., Takahashi, A., & Moseley, M. E. (1999) · NeuroImage · doi:10.1006/nimg.1998.0399 · Cited by 93 · see citing works
Nicotine receptors are located on lateral geniculate nucleus terminals in cat visual cortex
Prusky, G. T., Shaw, C., & Cynader, M. S. (1987) · Brain Research · doi:10.1016/0006-8993(87)91447-8 · Cited by 91 · see citing works
Angelucci, A., & Sainsbury, K. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21060 · Cited by 84 · see citing works
The spatial extent of the BOLD response
Saad, Z. S., Ropella, K. M., DeYoe, E. A., & Bandettini, P. A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00016-8 · Cited by 78 · see citing works
Negative BOLD fMRI Response in the Visual Cortex Carries Precise Stimulus-Specific Information
Bressler, D. W., Spotswood, N., & Whitney, D. C. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000410 · Cited by 78 · see citing works
Electrophysiological estimate of human cortical magnification
Slotnick, S. D., Klein, S. A., Carney, T., & Sutter, E. E. (2001) · Clinical Neurophysiology · doi:10.1016/s1388-2457(01)00561-2 · Cited by 76 · see citing works
Muscarinic Versus Nicotinic Modulation of a Visual Task A PET Study Using Drug Probes
Mentis, M. J. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00264-0 · Cited by 62 · see citing works
Impact of intravenous nicotine on BOLD signal response to photic stimulation
Jacobsen, L. K., Gore, J. C., Skudlarski, P., Lacadie, C., Jatlow, P. L., & Krystal, J. H. (2002) · Magnetic Resonance Imaging · doi:10.1016/s0730-725x(02)00494-0 · Cited by 60 · see citing works
Imaging vision : Functional mapping of intermediate visual processes in man
Larsson, J. T. (2001) · Figshare · Cited by 58 · see citing works
Functional MRI of brain during breath holding at 4 T
Stillman, A. E., Hu, X. P., & Jerosch‐Herold, M. (1995) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(95)00037-h · Cited by 50 · see citing works
Effect of Oral Donepezil on Intraocular Pressure in Normotensive Alzheimer Patients
Estermann, S., Daepp, G.-C., Cattapan-Ludewig, K., Berkhoff, M. M., Frueh, B. E., & Goldblum, D. (2006) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2006.22.62 · Cited by 21 · see citing works
Cholinergic mechanisms mediating anesthetic induced altered states of consciousness
Backman, S. B., Fiset, P., & Plourde, G. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)45014-0 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Modes and models of forebrain cholinergic neuromodulation of cognition
Hasselmo, M. E., & Sarter, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.104 · Cited by 733 · see citing works
Klinkenberg, I., & Blokland, A. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.04.001 · Cited by 714 · see citing works
Removing brakes on adult brain plasticity: From molecular to behavioral interventions
Bavelier, D., Levi, D. M., Li, R. W., Dan, Y., & Hensch, T. K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4812-10.2010 · Cited by 589 · see citing works
Grossberg, S. (2012) · Neural Networks · doi:10.1016/j.neunet.2012.09.017 · Cited by 542 · see citing works
Lynx1, a Cholinergic Brake, Limits Plasticity in Adult Visual Cortex
Morishita, H., Miwa, J. M., Heintz, N., & Hensch, T. K. (2010) · Science · doi:10.1126/science.1195320 · Cited by 365 · see citing works
Traveling Waves in Visual Cortex
Sato, T. K., Nauhaus, I., & Carandini, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.029 · Cited by 288 · see citing works
The cholinergic hypothesis of cognitive aging revisited again: Cholinergic functional compensation
Dumas, J. A., & NEWHOUSE, P. A. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.02.022 · Cited by 209 · see citing works
Cools, R., & Arnsten, A. F. T. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01100-8 · Cited by 206 · see citing works
Specific basal forebrain-cortical cholinergic circuits coordinate cognitive operations
Záborszky, L., Gombkoto, P., Varsanyi, P., Gielow, M. R., Poe, G., Role, L. W., Ananth, M., Rajebhosale, P., Talmage, D. A., Hasselmo, M. E., et al. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1676-18.2018 · Cited by 202 · see citing works
Cholinergic modulation of cognitive processing: insights drawn from computational models
Newman, E. L., Gupta, K., Climer, J. R., Monaghan, C. K., & Hasselmo, M. E. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00024 · Cited by 185 · see citing works
Cholinergic modulation of cognition: Insights from human pharmacological functional neuroimaging
Bentley, P., Driver, J., & Dolan, R. J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.06.002 · Cited by 173 · see citing works
Bloem, B., Poorthuis, R. B., & Mansvelder, H. D. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00017 · Cited by 146 · see citing works
Muscarinic Signaling in the Brain
Thiele, A. (2013) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062012-170433 · Cited by 136 · see citing works
Naber, M., Frässle, S., Rutishauser, U., & Einhäuser, W. (2013) · Journal of Vision · doi:10.1167/13.2.11 · Cited by 125 · see citing works
Population Response Profiles in Early Visual Cortex Are Biased in Favor of More Valuable Stimuli
Serences, J. T., & Saproo, S. (2010) · Journal of Neurophysiology · doi:10.1152/jn.01090.2009 · Cited by 97 · see citing works
Wan, L., Huang, H., Schwab, N., Tanner, J., Rajan, A., Lam, N. B., Zaborszky, L., Li, C. R., Price, C. C., & Ding, M. (2019) · Human Brain Mapping · doi:10.1002/hbm.24395 · Cited by 96 · see citing works
Rokem, A., & Silver, M. A. (2010) · Current Biology · doi:10.1016/j.cub.2010.08.027 · Cited by 86 · see citing works
Self-citationResolving multisensory and attentional influences across cortical depth in sensory cortices
Gau, R., Bazin, P., Trampel, R., Turner, R., & Noppeney, U. (2020) · eLife · doi:10.7554/elife.46856 · Cited by 76 · see citing works
Boosting visual cortex function and plasticity with acetylcholine to enhance visual perception
Kang, J. I., Huppé‐Gourgues, F., & Vaucher, E. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00172 · Cited by 77 · see citing works
Pfeffer, T. A., Ponce‐Alvarez, A., Meindertsma, T., Gahnstrom, C. J., van den Brink, R. L., Nolte, G., Tsetsos, K., Engel, A. K., Deco, G., & Donner, T. H. (2021) · Science Advances · doi:10.1126/sciadv.abf5620 · Cited by 77 · see citing works
Leveraging the cortical cholinergic system to enhance attention
Demeter, E., & Sarter, M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.060 · Cited by 75 · see citing works
Towards a Unified View on Pathways and Functions of Neural Recurrent Processing
Pennartz, C. M. A., Dora, S., Muckli, L., & Lorteije, J. A. M. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.07.005 · Cited by 73 · see citing works
“Do cholinergic projections contribute to stimulus-context modulation? In humans, increasing acetylcholine (ACh) levels through systemic drug application attenuates the spatial spread of visual responses as measured using functional magnetic resonance imaging (fMRI) [25] and reduces perceptual surround suppression [26].”
Luchicchi, A., Bloem, B., Viaña, J. N. M., Mansvelder, H. D., & Role, L. W. (2014) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2014.00024 · Cited by 70 · see citing works
Gratton, C., Yousef, S., Aarts, E., Wallace, D. L., D’Esposito, M., & Silver, M. A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2405-16.2017 · Cited by 63 · see citing works
Self-citationBerry, A. S., Demeter, E., Sabhapathy, S., English, B. A., Blakely, R., Sarter, M. F., & Lustig, C. (2014) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00607 · Cited by 66 · see citing works
Rokem, A., Landau, A. N., Garg, D., Prinzmetal, W., & Silver, M. A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.118 · Cited by 65 · see citing works
Self-citationNeural Representations of Relevant and Irrelevant Features in Perceptual Decision Making
Kayser, A. S., Erickson, D. T., Buchsbaum, B. R., & D’Esposito, M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3163-10.2010 · Cited by 61 · see citing works
Self-citationDistribution and effects of the muscarinic receptor subtypes in the primary visual cortex
Groleau, M., Kang, J. I., Huppé‐Gourgues, F., & Vaucher, E. (2015) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2015.00010 · Cited by 60 · see citing works
Cholinergic suppression of visual responses in primate V1 is mediated by GABAergic inhibition
Disney, A. A., Aoki, C., & Hawken, M. J. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00188.2012 · Cited by 57 · see citing works
Balsters, J. H., O’Connell, R. G., Martin, M. P., Galli, A., Cassidy, S. M., Kilcullen, S. M., Delmonte, S., Brennan, S., Meaney, J. F., Fagan, A. J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024126 · Cited by 56 · see citing works
Coppola, J. J., & Disney, A. A. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00008 · Cited by 48 · see citing works
Bressler, D. W., Fortenbaugh, F. C., Robertson, L. C., & Silver, M. A. (2013) · Vision Research · doi:10.1016/j.visres.2013.03.009 · Cited by 46 · see citing works
Self-citationKim, K., Müller, M. L. T. M., Bohnen, N. I., Sarter, M. F., & Lustig, C. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.02.006 · Cited by 46 · see citing works
Grossberg, S. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00082 · Cited by 43 · see citing works
Bentley, P., Driver, J., & Dolan, R. J. (2009) · Brain · doi:10.1093/brain/awp176 · Cited by 41 · see citing works
Kang, J. I., Groleau, M., Dotigny, F., Giguère, H., & Vaucher, E. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0582-y · Cited by 41 · see citing works
Spectrotemporal dynamics of auditory cortical synaptic receptive field plasticity
Froemke, R. C., & Martins, A. R. O. (2011) · Hearing Research · doi:10.1016/j.heares.2011.03.005 · Cited by 39 · see citing works
Acute cognitive effects of donepezil in young, healthy volunteers
Zaninotto, A. L., Bueno, O. F. A., Pradella‐Hallinan, M., Tufik, S. B., Rusted, J. M., Stough, C. K. K., & Pompéia, S. (2009) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1044 · Cited by 37 · see citing works
Cholinergic enhancement reduces orientation-specific surround suppression but not visual crowding
Kosovicheva, A. A., Sheremata, S., Rokem, A., Landau, A. N., & Silver, M. A. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00061 · Cited by 34 · see citing works
Self-citationMcAvoy, M. P., Larson‐Prior, L. J., Ludwikow, M., Zhang, D., Snyder, A. Z., Gusnard, D. L., Raichle, M. E., & d’Avossa, G. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00900.2011 · Cited by 31 · see citing works
Sensory processing: who's in (top‐down) control?
Ruff, C. C. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12204 · Cited by 30 · see citing works
Sheynin, Y., Chamoun, M., Baldwin, A. S., Rosa‐Neto, P., Hess, R. F., & Vaucher, E. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00022 · Cited by 30 · see citing works
Chamoun, M., Huppé‐Gourgues, F., Legault, I., Rosa‐Neto, P., Dumbrava, D., Faubert, J., & Vaucher, E. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00128 · Cited by 29 · see citing works
Brain Networks are Independently Modulated by Donepezil, Sleep, and Sleep Deprivation
Wirsich, J., Rey, M. F., Guye, M., Bénar, C., Lanteaume, L., Ridley, B., Sylviane Confort-gouny, A., Cassé‐Perrot, C., Soulier, E., Viout, P., et al. (2017) · Brain Topography · doi:10.1007/s10548-017-0608-5 · Cited by 29 · see citing works
Donepezil Does Not Enhance Perceptual Learning in Adults with Amblyopia: A Pilot Study
Chung, S. T. L., Li, R. W., Silver, M. A., & Levi, D. M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00448 · Cited by 24 · see citing works
Self-citationPalma, J., Grossberg, S., & Massimiliano Versace, A. (2012) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2012.00042 · Cited by 21 · see citing works
Potential roles of cholinergic modulation in the neural coding of location and movement speed
Dannenberg, H., Hinman, J. R., & Hasselmo, M. E. (2016) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2016.09.002 · Cited by 21 · see citing works
Chamoun, M., Groleau, M., Bhat, M., & Vaucher, E. (2016) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2016.11.010 · Cited by 19 · see citing works
Cholinergic modulation of sensory perception and plasticity
Kunnath, A. J., Gifford, R. H., & Wallace, M. T. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105323 · Cited by 19 · see citing works
Impaired functional organization in the visual cortex of muscarinic receptor knock-out mice
Groleau, M., Nguyen, H. N., Vanni, M. P., Huppé‐Gourgues, F., Casanova, C., & Vaucher, E. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.05.016 · Cited by 20 · see citing works
Sabarudin, A., Sun, Z., & Kh, N. (2013) · Singapore Medical Journal · doi:10.11622/smedj.2013005 · Cited by 18 · see citing works
Beerendonk, L., Mejías, J. F., Nuiten, S. A., de Gee, J. W., Zantvoord, J. B., Fahrenfort, J. J., & van Gaal, S. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2419733122 · Cited by 17 · see citing works
Cholinergic Modulation of Binocular Vision
Sheynin, Y., Rosa‐Neto, P., Hess, R. F., & Vaucher, E. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2484-19.2020 · Cited by 15 · see citing works
Acute caffeine ingestion affects surround suppression of perceived contrast
Nguyen, B. N., Hew, S.-A., Ly, J. V., Shin, H., Wong, J. C., Yeung, E., & McKendrick, A. M. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117725684 · Cited by 13 · see citing works
Hasselmo, M. E. (2024) · Hippocampus · doi:10.1002/hipo.23676 · Cited by 17 · see citing works
Cholinergic modulation of hippocampally mediated attention and perception.
Ruiz, N. A., Thieu, M. K., & Aly, M. (2020) · Behavioral Neuroscience · doi:10.1037/bne0000405 · Cited by 12 · see citing works
Metaplasticity: Dark exposure boosts local excitability and visual plasticity in adult human cortex
Min, S. H., Wang, Z., Chen, M. T., Hu, R., Gong, L., He, Z., Wang, X., Hess, R. F., & Zhou, J. (2023) · The Journal of Physiology · doi:10.1113/jp284040 · Cited by 13 · see citing works
Erickson, D. T., & Kayser, A. S. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.085 · Cited by 13 · see citing works
Metzger, F. G., Ehlis, A., Haeussinger, F. B., Fallgatter, A. J., & Hagen, K. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4066-z · Cited by 13 · see citing works
Cholinergic potentiation of visual perception and vision restoration in rodents and humans
Vaucher, E., Laliberté, G., Higgins, M.-C., Maheux, M., Jolicœur, P., & Chamoun, M. (2019) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-190947 · Cited by 10 · see citing works
High-level modulations of binocular rivalry
Bressler, D. W., Denison, R. N., & Silver, M. A. (2013) · Advances in consciousness research · doi:10.1075/aicr.90.10bre · Cited by 10 · see citing works
Self-citationChen, X., Hall, K., Bobier, W. R., Thompson, B. S., & Chakraborty, A. (2022) · Journal of Vision · doi:10.1167/jov.22.10.14 · Cited by 9 · see citing works
Effects of involuntary and voluntary attention on critical spacing of visual crowding
Bowen, J. D., Alforque, C. V., & Silver, M. A. (2023) · Journal of Vision · doi:10.1167/jov.23.3.2 · Cited by 9 · see citing works
Self-citationHandjaras, G., Ricciardi, E., Szczepanik, J. E., Pietrini, P., & Furey, M. L. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213497326 · Cited by 9 · see citing works
Long-range inputome of cortical neurons containing corticotropin-releasing hormone
Zhao, P., Zhao, M., Wang, H., Jiang, T., Jia, X., Tian, J., Li, A., Gong, H., & Li, X. (2020) · Scientific Reports · doi:10.1038/s41598-020-68115-x · Cited by 9 · see citing works
Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision-making
Nuiten, S. A., de Gee, J. W., Zantvoord, J. B., Fahrenfort, J. J., & van Gaal, S. (2023) · eLife · doi:10.7554/elife.87022 · Cited by 9 · see citing works
Ocular Dominance Plasticity: A Mini-Review
Min, S. H. (2025) · Eye and Brain · doi:10.2147/eb.s532627 · Cited by 8 · see citing works
Berthier, M. L., Santana-Moreno, D., Beltrán‐Corbellini, Á., Criado, J. C., Edelkraut, L., López-Barroso, D., Dávila, G., & Torres‐Prioris, M. J. (2021) · Aphasiology · doi:10.1080/02687038.2021.1957082 · Cited by 7 · see citing works
Byrne, K. N., McDevitt, E. A., Sheremata, S., Peters, M. W., Mednick, S. C., & Silver, M. A. (2020) · Journal of Vision · doi:10.1167/jov.20.6.5 · Cited by 5 · see citing works
Self-citationYoshino, Y., Mori, T., Yoshida, T., Toyota, Y., Shimizu, H., Iga, J., Nishitani, S., & Ueno, S. (2017) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2017.15.3.243 · Cited by 3 · see citing works
Malavita, M. S., Vidyasagar, T. R., & McKendrick, A. M. (2021) · Journal of Vision · doi:10.1167/jov.21.1.13 · Cited by 3 · see citing works
CORTICAL CHOLINERGIC TRANSIENTS FOR CUE DETECTION AND ATTENTIONAL MODE SHIFTS
Sarter, M. F., Howe, W. M., & Gritton, H. J. (2014) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814619776_0002 · Cited by 3 · see citing works
Neither Cholinergic Nor Dopaminergic Enhancement Improve Spatial Working Memory Precision in Humans
Harewood, A., Challa, J. A., & Silver, M. A. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00094 · Cited by 3 · see citing works
Self-citationUncertainty calculation of indoor and outdoor performance measurements for PV modules
Perrin, A.-L., Chabli, A., Razongles, G., & Doucet, O. (2019) · International Congress of Metrology (CIM) · doi:10.1051/metrology/201908002 · Cited by 2 · see citing works
Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1
Herrero, J. L., & Thiele, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-88044-7 · Cited by 2 · see citing works
Cholinergic modulation of motor sequence learning
Voegtle, A., Mohrbutter, C., Hils, J., Schulz, S., Weuthen, A., Brämer, U., Ullsperger, M., & Sweeney‐Reed, C. M. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16374 · Cited by 2 · see citing works
Phasic and tonic arousal distinctly shape human decision bias
Nuiten, S. A., de Gee, J. W., Zantvoord, J. B., Sterzer, P., Fahrenfort, J. J., & van Gaal, S. (2026) · Communications Biology · doi:10.1038/s42003-026-09776-8 · Cited by 3 · see citing works
Relating Cortical Wave Dynamics to Learning and Remembering
Mercado, E. (2014) · AIMS neuroscience · doi:10.3934/neuroscience.2014.3.185 · Cited by 2 · see citing works
Groleau, M., Chamoun, M., & Vaucher, E. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.06.023 · Cited by 2 · see citing works
Dissociation between catecholamines and acetylcholine in the human cerebral cortexPreprint
Pfeffer, T. A., Ponce‐Alvarez, A., Meindertsma, T., Gahnstrom, C. J., van den Brink, R. L., Nolte, G., Tsetsos, K., Engel, A. K., Deco, G., & Donner, T. H. (2020) · Bristol Research (University of Bristol) · doi:10.1101/2020.06.25.171199 · Cited by 4 · see citing works
Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision makingPreprint
Nuiten, S. A., de Gee, J. W., Fahrenfort, J. J., & van Gaal, S. (2023) · eLife · doi:10.7554/elife.87022.1 · Cited by 2 · see citing works
Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision-making
Nuiten, S. A., de Gee, J. W., Zantvoord, J. B., Fahrenfort, J. J., & van Gaal, S. (2023) · eLife · doi:10.7554/elife.87022.3 · Cited by 1 · see citing works
Laliberté, G., Othman, R., & Vaucher, E. (2020) · Frontiers in Neural Circuits · doi:10.3389/fncir.2020.00038 · Cited by 1 · see citing works
Effects of cholinesterase inhibition on brain function
Bentley, P. (2011) · UCL Discovery (University College London)
Tsui, C. K. Y. (2011) · QSpace (Queen's University Library)
Smith, D. (2015) · uO Research (University of Ottawa) · doi:10.20381/ruor-4012
is mediated by GABAergic inhibition Cholinergic suppression of visual responses in primate V1
Disney, A., Aoki, C. J., & Hawken, M. J. (2012)
Propagating Cortical Waves May Underlie Illusory Motion Perception
Bacigalupo, F., Davis, Z. W., Napan, J., & Royston, A. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1167-16.2016
Spatial Resolution in Perception and Working Memory
Smith, H., & Natasha, A. (2017)
Actividad colinérgica y su papel en el sistema visual
Durán‐Cristiano, S. C. (2022) · Revista Mexicana de Oftalmología · doi:10.24875/rmo.m21000214
Lawn, T., Martins, D., O’Daly, O., Williams, S., Howard, M. A., & Dipasquale, O. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.24.493298 · Cited by 1 · see citing works
Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision-makingPreprint
Nuiten, S. A., de Gee, J. W., Zantvoord, J. B., Fahrenfort, J. J., & van Gaal, S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.03.515022
Nuiten, S. A., De Gee, J. W., Fahrenfort, J. J., et al. (2023) · eLife · doi:10.7554/elife.87022.1.sa0
Nuiten, S. A., De Gee, J. W., Fahrenfort, J. J., et al. (2023) · eLife · doi:10.7554/elife.87022.1.sa1
Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision-makingPreprint
Nuiten, S. A., de Gee, J. W., Zantvoord, J. B., Fahrenfort, J. J., & van Gaal, S. (2023) · eLife · doi:10.7554/elife.87022.2
Berthier, M. L., Gómez-Pérez, Á. Y., Dávila, G., Torres‐Prioris, M. J., Birba, A., & García, A. M. (2026) · Aphasiology · doi:10.1080/02687038.2026.2708827
Hasselmo, M. E. (2013) · Springer eBooks · doi:10.1007/978-1-4614-1424-7_10
- Authors
- Silver, M. A., Shenhav, A., & D'Esposito, M.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Silver, Michael A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 60
- Issue
- 5
- Pages
- 904-914
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2640421
- OpenAlex
- W2121194451
- Cited by
- 100
- References
- 68
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 10 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 10 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 10 · 2012: 10
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1689 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH063901, R01-MH63901)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- acetylcholine, cholinergic stimulation, donepezil, cholinesterase inhibitors, early visual cortex, receptive field size, spatial integration, thalamocortical transmission, intracortical connections, human visual cortex
- MeSH terms
- Donepezil, Acetylcholine, Brain Mapping, Cholinesterase Inhibitors, Double-Blind Method, Eye Movements, Female, Humans, Image Processing, Computer-Assisted, Indans, Magnetic Resonance Imaging, Male, Oxygen, Photic Stimulation, Piperidines, Psychophysics, Time Factors, Visual Cortex, Visual Pathways
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
