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Cited by 31Multisensory perception and integrationTactile and Sensory InteractionsAction Observation and Synchronization

Audio–visual and olfactory–visual integration in healthy participants and subjects with autism spectrum disorder

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Stickel, Susanne, Weismann, Pauline, Kellermann, Thilo, Regenbogen, Christina, Habel, Ute, Freiherr, Jessica, Chechko, Natalya·2019·Human Brain Mapping
DOI 10.1002/hbm.24715PMC PMC6865810
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Abstract

The human capacity to integrate sensory signals has been investigated with respect to different sensory modalities. A common denominator of the neural network underlying the integration of sensory clues has yet to be identified. Additionally, brain imaging data from patients with autism spectrum disorder (ASD) do not cover disparities in neuronal sensory processing. In this fMRI study, we compared the underlying neural networks of both olfactory–visual and auditory–visual integration in patients with ASD and a group of matched healthy participants. The aim was to disentangle sensory‐specific networks so as to derive a potential (amodal) common source of multisensory integration (MSI) and to investigate differences in brain networks with sensory processing in individuals with ASD. In both groups, similar neural networks were found to be involved in the olfactory–visual and auditory–visual integration processes, including the primary visual cortex, the inferior parietal sulcus (IPS), and the medial and inferior frontal cortices. Amygdala activation was observed specifically during olfactory–visual integration, with superior temporal activation having been seen during auditory–visual integration. A dynamic causal modeling analysis revealed a nonlinear top‐down IPS modulation of the connection between the respective primary sensory regions in both experimental conditions and in both groups. Thus, we demonstrate that MSI has shared neural sources across olfactory–visual and audio–visual stimulation in patients and controls. The enhanced recruitment of the IPS to modulate changes between areas is relevant to sensory perception. Our results also indicate that, with respect to MSI processing, adults with ASD do not significantly differ from their healthy counterparts.

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  • Dynamic functional brain networks are altered in children diagnosed with ASD, including cognitive control, subcortical, auditory, visual, bilateral limbic, and default-mode network.

    “Results show dynamic functional brain networks altered in children diagnosed with ASD, including cognitive control, subcortical, auditory, visual, bilateral limbic, and default-mode network (Stickel et al. 2019).”

    From Autism Spectrum Disorder and auditory sensory alterations: a systematic review on the integrity of cognitive and neuronal functions related to auditory processing (2023) · cites this paper as Stickel et al. 2019

    The Introduction (page unavailable) reports prior findings of weaker audio–visual multisensory facilitation and ineffective neural integration in children with ASD. It does not report altered dynamic functional networks across the six named network categories. This paper studied adults; its Discussion Summary (page unavailable) reports overlapping multisensory-integration networks in the ASD and healthy groups. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Stickel, S., Weismann, P., Kellermann, T., Regenbogen, C., Habel, U., Freiherr, J., & Chechko, N.
Affiliations
  • Forschungszentrum Jülich (DE)
  • Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
  • Department of Psychiatry, Psychotherapy and Psychosomatics Faculty of Medicine, RWTH Aachen Aachen Germany
Corresponding author
Stickel, Susanne
ORCID
Venue
Human Brain Mapping
Publisher
Wiley
Published
2019-07-13
Volume
40
Issue
15
Pages
4470-4486
ISSN
  • 1065-9471 (ISSN-L)
  • 1097-0193
DOI
10.1002/hbm.24715
PMC
PMC6865810
OpenAlex
W2956594516
Cited by
31
References
8
Citations by year
2026: 4 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 2
FWCI
3.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Human Brain Mapping (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft) (submittedVersion, other-oa)
  • Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
  • RWTH Publications (RWTH Aachen) (submittedVersion, other-oa)
Funders
  • Deutsche Forschungsgemeinschaft (IRTG 2150)
  • RWTH Aachen University (START 17/14)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
Keywords
multisensory integration, autism spectrum disorder, audiovisual integration, top-down modulation, amygdala, primary visual cortex, dynamic causal modeling, sensory processing
MeSH terms
Autism Spectrum Disorder, Adolescent, Adult, Auditory Perception, Bayes Theorem, Brain Mapping, Child, Child, Preschool, Female, Humans, Magnetic Resonance Imaging, Male, Models, Neurological, Models, Psychological, Smell, Visual Perception, Case-Control Studies, Young Adult, Pleasure

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