The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
Nasopharyngeal carcinoma—Review of the molecular mechanisms of tumorigenesis
Open accessAbstract
Nasopharyngeal carcinoma (NPC) is a head and neck cancer rare throughout most of the world but common in certain geographic areas, such as southern Asia. While environmental factors and genetic susceptibility play important roles in NPC pathogenesis, the Epstein–Barr virus in particular has been implicated in the molecular abnormalities leading to NPC. There is upregulation of cellular proliferation pathways such as the Akt pathway, mitogen‐activated protein kinases, and the Wnt pathway. Cell adhesion is compromised due to abnormal E‐cadherin and β‐catenin function. Aberrations in cell cycle are due to dysregulation of factors such as p16, cyclin D1, and cyclin E. Anti‐apoptotic mechanisms are also upregulated. There are multiple abnormalities unique to NPC that are potential targets for novel treatments. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
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Cited by
MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma
Chen, H.-C., Chen, G.-H., Chen, Y.-H., Liao, W.-L., Liu, C.-Y., Chang, K.-P., Chang, Y.-S., & Chen, S.-J. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6604948 · Cited by 276
Metadata
- Authors
- Chou, J., Lin, Y., Kim, J., You, L., Xu, Z., He, B., & Jablons, D. M.
- Venue
- Head & Neck
- Publisher
- Wiley
- Published
- 2008-04-29
- Volume
- 30
- Issue
- 7
- Pages
- 946-963
- ISSN
- 1043-3074 (ISSN-L)
- 1097-0347
- OpenAlex
- W2131465172
- Cited by
- 317
- References
- 147
- FWCI
- 16.09
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
