Prediction of hypocalcemia after using 1‐ to 6‐hour postoperative parathyroid hormone and calcium levels: An analysis of pooled individual patient data from 3 observational studies
Abstract
Background.: Parathyroid hormone (PTH) levels up to 6 hours postthyroidectomy have been shown to have excellent predictive power in determining hypocalcemia. In this study, we investigate the usefulness of combining calcium and PTH to increase the predictive power. Methods.: Individual patient data were obtained from 3 studies (152 patients) that fulfilled our criteria (using PTH assay within hours postthyroidectomy to predict symptomatic hypocalcemia). Results.: Changes in combined PTH and calcium threshold levels checked 1 to 6 hours after thyroidectomy were excellent in predicting postoperative hypocalcemia. A decrease in PTH of 60%, coupled with a simultaneous decrease in calcium of 10%, 5 to 6 hours postoperatively resulted in a sensitivity and specificity of 100%. However, combined PTH and calcium threshold changes were not significantly better than using PTH threshold changes alone. Conclusions.: Threshold changes in serum calcium and PTH, checked hours after surgery, can be used together to accurately predict whether a patient will become hypocalcemic after thyroidectomy. © 2009 Wiley Periodicals, Inc. Head Neck, 2010
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Successful prediction of calcium status after total thyroidectomy can be achieved using the slope of 6- and 12-hour postoperative calcium levels.
“Successful prediction of calcium status after total thyroidectomy can be achieved using the slope of 6-and 12-hour postoperative calcium levels (204-210).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [208]
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- Authors
- Jumaily, J. S., Noordzij, J. P., Dukas, A. G., Lee, S. L., Bernet, V. J., Payne, R. J., McLeod, I. K., Hier, M. P., Black, M. J., Kerr, P. D., Raffaelli, M., Bellantone, R., Lombardi, C. P., & Dietrich, M. S.
- Affiliations
- Boston University (US)
- Walter Reed National Military Medical Center (US)
- Jewish General Hospital (CA)
- University of Manitoba (CA)
- Università Cattolica del Sacro Cuore (IT)
- Vanderbilt University (US)
- Corresponding author
- Noordzij, J. Pieter
- ORCID
- Venue
- Head & Neck
- Publisher
- Wiley
- Published
- 2009-09-24
- Volume
- 32
- Issue
- 4
- Pages
- 427-434
- ISSN
- 1043-3074 (ISSN-L)
- 1097-0347
- OpenAlex
- W2095551288
- Cited by
- 54
- References
- 34
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 2 · 2015: 8 · 2014: 5 · 2013: 3 · 2012: 5
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Head & Neck (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Keywords
- postoperative hypocalcemia, parathyroid hormone, serum calcium, thyroidectomy, hypocalcemia prediction
- MeSH terms
- Calcium, Female, Follow-Up Studies, Humans, Hypocalcemia, Male, Parathyroid Hormone, Postoperative Care, Predictive Value of Tests, Probability, Registries, ROC Curve, Thyroidectomy, Time Factors, Cohort Studies, Biomarkers, Incidence, Confidence Intervals, Risk Assessment, Area Under Curve
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