The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Single‐marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase
Open accessAbstract
Background: In accord with the cancer stem cell (CSC) theory, only a small subset of cancer cells are capable of forming tumors. We previously reported that CD44 isolates tumorigenic cells from head and neck squamous cell cancer (HNSCC). Recent studies indicate that aldehyde dehydrogenase (ALDH) activity may represent a more specific marker of CSCs. Methods: Six primary HNSCCs were collected. Cells with high and low ALDH activity (ALDH high/ALDH low) were isolated. ALDH high and ALDH low populations were implanted into NOD/SCID mice and monitored for tumor development. Results: ALDH high cells represented a small percentage of the tumor cells (1% to 7.8%). ALDH high cells formed tumors from as few as 500 cells in 24/45 implantations, whereas only 3/37 implantations of ALDH low cells formed tumors. Conclusions: ALDH high cells comprise a subpopulation cells in HNSCCs that are tumorigenic and capable of producing tumors at very low numbers. This finding indicates that ALDH activity on its own is a highly selective marker for CSCs in HNSCC. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
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Cites
Prospective identification of tumorigenic breast cancer cells
Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J., & Clarke, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530291100 · Cited by 10,370
Self-citationStem cells, cancer, and cancer stem cells
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Identification of human brain tumour initiating cells
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Self-citationPrince, M. E., Sivanandan, R., Kaczorowski, A., Wolf, G. T., Kaplan, M. J., Dalerba, P., Weissman, I. L., Clarke, M. F., & Ailles, L. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610117104 · Cited by 2,164
Self-citationCancerous stem cells can arise from pediatric brain tumors
Hemmati, H. D., Nakano, I., Lazareff, J. A., Masterman-Smith, M., Geschwind, D. H., Bronner-Fraser, M., & Kornblum, H. I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2036535100 · Cited by 1,817
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Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
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“Accumulated evidence indicates that CSCs retain phenotypic features of their cell of origin, irrespective of whether that is a stem cell or an early progenitor cell.(9,10) Stem cell markers or molecular processes that are also expressed on CSCs should provide the means to identify and study CSCs.”
BackgroundCancer stem cells: an old idea–a paradigm shift
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Cited by
Mechanisms of chemoresistance in cancer stem cells
Abdullah, L. N., & Chow, E. K. (2013) · Clinical and Translational Medicine · doi:10.1186/2001-1326-2-3 · Cited by 721
ALDH1A Isozymes are Markers of Human Melanoma Stem Cells and Potential Therapeutic Targets
Luo, Y., Dallaglio, K., Chen, Y., Robinson, W. A., Robinson, S. E., McCarter, M. D., Wang, J., Gonzalez, R., Thompson, D. C., Norris, D. A., et al. (2012) · Stem Cells · doi:10.1002/stem.1193 · Cited by 281
Metadata
- Authors
- Clay, M. R., Tabor, M., Owen, J. H., Carey, T. E., Bradford, C. R., Wolf, G. T., Wicha, M. S., & Prince, M. E.
- Venue
- Head & Neck
- Publisher
- Wiley
- Published
- 2010-08-23
- Volume
- 32
- Issue
- 9
- Pages
- 1195-1201
- ISSN
- 1043-3074 (ISSN-L)
- 1097-0347
- OpenAlex
- W2153101406
- Cited by
- 447
- References
- 29
- FWCI
- 17.52
- Type
- journal article
- Language
- en
- Open access
- green
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