The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Mechanisms of chemoresistance in cancer stem cells
Open accessAbstract
Chemotherapy is one of the standard methods of treatment in many cancers. While chemotherapy is often capable of inducing cell death in tumors and reducing the tumor bulk, many cancer patients experience recurrence and ultimately death because of treatment failure. In recent years, cancer stem cells (CSCs) have gained intense interest as key tumor‐initiating cells that may also play an integral role in recurrence following chemotherapy. As such, a number of mechanisms of chemoresistance have been identified in CSCs. In this review, we describe a number of these mechanisms of chemoresistance including ABC transporter expression, aldehyde dehydrogenase (ALDH) activity, B‐cell lymphoma‐2 (BCL2) related chemoresistance, enhanced DNA damage response and activation of key signaling pathways. Furthermore, we evaluate studies that demonstrate potential methods for overcoming chemoresistance and treating chemoresistant cancers that are driven by CSCs. By understanding how tumor‐initiating cells such as CSCs escape chemotherapy, more informed approaches to treating cancer will develop and may improve clinical outcomes for cancer patients.
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Cites
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Cited by
Nunes, A. S., Barros, A. S., Costa, E. C., Moreira, A. F., & Correia, I. J. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.26845 · Cited by 721
The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance
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Metadata
- Authors
- Abdullah, L. N., & Chow, E. K.
- Venue
- Clinical and Translational Medicine
- Publisher
- Wiley
- Published
- 2013-01-17
- Volume
- 2
- Issue
- 1
- Pages
- 3-3
- ISSN
- 2001-1326 (ISSN-L)
- OpenAlex
- W2124185479
- Cited by
- 721
- References
- 93
- FWCI
- 29.88
- Type
- journal article
- Language
- en
- Open access
- gold
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