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A controlled clinical trial of the efficacy of the hepatitis B vaccine (heptavax B): A final report
Open accessAbstract
A controlled, randomized, double-blind trial in 1,083 homosexual men from New York confirmed that a highly purified, formalin-inactivated vaccine against hepatitis B prepared from HBsAg positive plasma, is safe immunogenic, and highly efficacious. Over 95% of vaccinated subjects developed antibody against the surface antigen. Vaccine-induced antibody persisted for the entire 24-month follow-up period. The attack rate of all hepatitis B virus infections (excluding conversions of anti-HBc alone) was 3.2% in vaccine recipients compared with 25.6% in placebo recipients (p < 0.0001). In those who received all three doses of vaccine, of 40 μg each, the protective efficacy rate was close to 100%. The vaccine protects against acute hepatitis B, asymptomatic infection, and chronic antigenemia. There is reason to assume that the vaccine is also partially effective when given postexposure.
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Citations
Cited by
Correlates of protection induced by vaccination
Plotkin, S. A. (2010) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00131-10 · Cited by 1,745
Long-Term Immunogenicity and Efficacy of Hepatitis B Vaccine in Homosexual Men
Hadler, S. C., Francis, D. P., Maynard, J. E., Thompson, S. E., Judson, F. N., Echenberg, D. F., Ostrow, D. G., O'Malley, P. M., Penley, K. A., Altman, N. L., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198607243150401 · Cited by 608
Risks of chronicity following acute hepatitis B virus infection: a review.
Hyams, K. C. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/20.4.992 · Cited by 521
West, D. (1996) · Vaccine · doi:10.1016/0264-410x(96)00062-x · Cited by 375
Heshin‐Bekenstein, M., Turner, D., Shamir, R., Bar‐Meir, M., Dagan, R., Zevit, N., & Silbermintz, A. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000856 · Cited by 13
Metadata
- Authors
- Szmuness, W., Stevens, C. E., Zang, E. A., Harley, E. J., & Kellner, A.
- Venue
- Hepatology
- Published
- 1981-09
- Volume
- 1
- Issue
- 5
- Pages
- 377-385
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2170308370
- Cited by
- 457
- References
- 0
- FWCI
- 28.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: A controlled clinical trial of the efficacy of the hepatitis B vaccine (heptavax B): A final report. https://app.cochat.ai/papers/10.1002/hep.1840010502
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- Szmuness, W., Stevens, C. E., Zang, E. A., Harley, E. J., & Kellner, A. (1981). A controlled clinical trial of the efficacy of the hepatitis B vaccine (heptavax B): A final report. Hepatology. https://doi.org/10.1002/hep.1840010502
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
