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Early recognition of hepatocellular carcinoma
Open accessAbstract
Primary liver cancer (PLC) is a malignant disease which is difficult to detect in its early stages and has very poor prognosis.Although relatively uncommon among Caucasians it is one of the major malignancies in many countries throughout the world, particularly in sub-Saharan Africa and the Far East.It accounts for 65.5% of all malignant disease in men and 31% of malignant tumors in women among Shangaan blacks in South Africa (1).It is the third major cause of cancer death in males and the fourth among females in China (2); it ranked third and fifth in these groups, respectively, in Japan in 1983 (3).Of PLC, hepatocellular carcinoma (HCC) is the major histological type followed in frequency by cholangiocellular carcinoma-the ratio of HCC to cholangiocellular carcinoma varies from 5:l to nearly 401 (4).In other words, the major malignant killer in the high PLC incidence areas is HCC.A close association of HCC with cirrhosis, particularly the posthepatitic or macronodular variety, has long been known (5-7).This interrelationship, an enigma in the
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Cited by
DI BISCEGLIE, A. M., RUSTGI, V. K., HOOFNAGLE, J. H., DUSHEIKO, G. M., & LOTZE, M. T. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-390 · Cited by 454
Ikeda, K., Saitoh, S., Suzuki, Y., Kobayashi, M., Tsubota, A., Koida, I., Arase, Y., Fukuda, M., Chayama, K., Murashima, N., et al. (1998) · Journal of Hepatology · doi:10.1016/s0168-8278(98)80339-5 · Cited by 428
Guidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults
Ryder, S. D. (2003) · Gut · doi:10.1136/gut.52.suppl_3.iii1 · Cited by 422
Early Hepatocellular Carcinoma As An Entity With A High Rate of Surgical Cure
Takayama, T., Makuuchi, M., Hirohashi, S., Sakamoto, M., Yamamoto, J., Shimada, K., Kosuge, T., Okada, S., Takayasu, K., & Yamasaki, S. (1998) · Hepatology · doi:10.1002/hep.510280511 · Cited by 388
Gaiani, S., Gramantieri, L., Venturoli, N., Piscaglia, F., Siringo, S., D'Errico, A., Zironi, G., Grigioni, W., & Bolondi, L. (1997) · Journal of Hepatology · doi:10.1016/s0168-8278(97)80140-7 · Cited by 271
Metadata
- Authors
- Okuda, K.
- Venue
- Hepatology
- Published
- 1986-07
- Volume
- 6
- Issue
- 4
- Pages
- 729-738
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2099534259
- Cited by
- 310
- References
- 0
- FWCI
- 13.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
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