The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Contribution of No-reflow phenomenon to hepatic injury after ischemia-reperfusion: Evidence for a role for superoxide anion
Abstract
Controversy exists as to the role of oxygen-derived free radicals in tissue injury and the no-reflow phenomenon in reperfusion injury after ischemia. In this study using an experimental rat model, left hepatic lobar ischemia followed by reperfusion resulted in an increase of serum glutamic pyruvic transaminase at 30 min with concomitant histological evidence of hepatocellular necrosis at 24 hr. In the in vivo liver microcirculation, reperfusion after ischemia resulted in an initial transient return of blood flow, but stasis of blood flow later developed in the liver sinusoids. Thus a no-reflow phenomenon in the microcirculation was demonstrated. Intravenous administration of a longacting form of superoxide dismutase (half-life 6 hr, dose 4 or 8 mg/kg) significantly decreased the hepatocellular necrosis and reduced the microcirculatory stasis in the liver sinusoids. These studies established the important contribution of the no-reflow phenomenon in ischemia-reperfusion injury to the liver and the participation of superoxide anions in mediating the no-reflow phenomenon.
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Citations
Cites
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399
The “no-reflow” phenomenon after temporary coronary occlusion in the dog
Kloner, R. A., Ganote, C. E., & Jennings, R. B. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107898 · Cited by 1,842
Cited by
Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning
Jaeschke, H. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00342.2002 · Cited by 852
Prospective Evaluation of Pringle Maneuver in Hepatectomy for Liver Tumors by a Randomized Study
Man, K., Fan, S.-T., Ng, I. O. L., Lo, C.-M., Liu, C.-L., & Wong, J. (1997) · Annals of Surgery · doi:10.1097/00000658-199712000-00007 · Cited by 444
Müller, M. J., Vollmar, B., Friedl, H.-P., & Menger, M. D. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(96)00028-7 · Cited by 51
Metadata
- Authors
- Koo, A., Komatsu, H., Tao, G., Inoue, M., Guth, P. H., & Kaplowitz, N.
- Venue
- Hepatology
- Published
- 1992-03
- Volume
- 15
- Issue
- 3
- Pages
- 507-514
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2048098639
- Cited by
- 221
- References
- 2
- FWCI
- 13.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Koo, A., Komatsu, H., Tao, G., Inoue, M., Guth, P. H., & Kaplowitz, N. (1992). Contribution of No-reflow phenomenon to hepatic injury after ischemia-reperfusion: Evidence for a role for superoxide anion. Hepatology. https://doi.org/10.1002/hep.1840150325
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
