Bile duct destruction by 4,4′-diaminodiphenylmethane does not block the small hepatocyte-like progenitor cell response in retrorsine-exposed rats
Abstract
Unlabelled Liver regeneration after surgical partial hepatectomy (PH) in retrorsine-exposed rats is accomplished through the outgrowth and expansion of small hepatocyte-like progenitor cells (SHPCs). The cells of origin for SHPCs and their tissue niche have not been identified. Nevertheless, some investigators have suggested that SHPCs may represent an intermediate or transitional cell type between oval cells and mature hepatocytes, rather than a distinct progenitor cell population. We investigated this possibility through the targeted elimination of oval cell proliferation secondary to bile duct destruction in retrorsine-exposed rats treated with 4,4'-diaminodiphenylmethane (DAPM). Fischer 344 rats were treated with 2 doses (30 mg/kg body weight) retrorsine (at 6 and 8 weeks of age) followed by PH 5 weeks later. Twenty-four hours before PH, select animals were given a single dose of DAPM (50 mg/kg). Treatment of rats with DAPM produced severe bile duct damage but did not block liver regeneration. Oval cells were never seen in the livers of DAPM-treated retrorsine-exposed rats after PH. Rather, liver regeneration in these rats was mediated by the proliferation of SHPCs, and the cellular response was indistinguishable from that observed in retrorsine-exposed rats after PH. SHPC clusters emerge 1 to 3 days post-PH, expand through 21 days post-PH, with normalization of the liver occurring by the end of the experimental interval. Conclusion These results provide direct evidence t…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hepatocytes are the source of small hepatocytes.
“a number of different approaches demonstrated that hepatocytes are the source of small hepatocytes.[143], [144], [145], [146]”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [144]
Cites
Experimental pathology of the liver
Higgins, G. (1931) · Medical Entomology and Zoology · Cited by 4,057 · see citing works
Higgins, G. (1931) · Cited by 2,444 · see citing works
Liver regeneration: from myth to mechanism
Taub, R. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1489 · Cited by 1,567 · see citing works
Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells
Fausto, N. (2004) · Hepatology · doi:10.1002/hep.20214 · Cited by 720 · see citing works
The role of hepatocytes and oval cells in liver regeneration and repopulation
Fausto, N., & Campbell, J. S. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00338-6 · Cited by 646 · see citing works
A precursor—product relationship exists between oval cells and hepatocytes in rat liver
Evarts, R. P., Nagy, P., Marsden, E. R., & Thorgeirsson, S. S. (1987) · Carcinogenesis · doi:10.1093/carcin/8.11.1737 · Cited by 447 · see citing works
Laconi, E., Oren, R., Mukhopadhyay, D. K., Hurston, E., Laconi, S., Pani, P., Dabeva, M. D., & Shafritz, D. A. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65574-5 · Cited by 381 · see citing works
In vivo differentiation of rat liver oval cells into hepatocytes.
Evarts, R. P., Nagy, P., Nakatsukasa, H., Marsden, E. R., & Thorgeirsson, S. S. (1989) · PubMed · Cited by 321 · see citing works
Michalopoulos, G. K., Barua, L., & Bowen, W. C. (2005) · Hepatology · doi:10.1002/hep.20600 · Cited by 319 · see citing works
A Transgenic Mouse Model of the Chronic Hepatitis B Surface Antigen Carrier State
Chisari, F. V., Pinkert, C. A., Milich, D. R., Filippi, P., McLachlan, A., Palmiter, R. D., & Brinster, R. L. (1985) · Science · doi:10.1126/science.3865369 · Cited by 289 · see citing works
Young, W., & Black, A. C. (2003) · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.10134 · Cited by 272 · see citing works
Gordon, G. J., Coleman, W. B., Hixson, D. C., & Grisham, J. W. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64765-7 · Cited by 187 · see citing works
Self-citationOval cell‐mediated liver regeneration: Role of cytokines and growth factors
Lowes, K. N., Croager, E. J., Olynyk, J. K., Abraham, L. J., & Yeoh, G. C. (2002) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2003.02906.x · Cited by 163 · see citing works
Gordon, G. J., Coleman, W. B., & Grisham, J. W. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64591-9 · Cited by 140 · see citing works
Self-citationPanduro, A., Shalaby, F., Weiner, F. R., Biempica, L., Zern, M. Α., & Shafritz, D. A. (1986) · Biochemistry · doi:10.1021/bi00354a034 · Cited by 135 · see citing works
Alison, M. R., Golding, M., Lalani, E., Nagy, P., Thorgeirsson, S. S., & Sarraf, C. (1997) · Journal of Hepatology · doi:10.1016/s0168-8278(97)80051-7 · Cited by 119 · see citing works
The sources of parenchymal regeneration after chronic hepatocellular liver injury in mice
Vig, P., Russo, F. P., Edwards, R. J., Tadrous, P. J., Wright, N. A., Thomas, H. C., Alison, M. R., & Forbes, S. J. (2006) · Hepatology · doi:10.1002/hep.21018 · Cited by 118 · see citing works
Paku, S., Nagy, P., Kopper, L., & Thorgeirsson, S. S. (2004) · Hepatology · doi:10.1002/hep.20178 · Cited by 117 · see citing works
Bile ductular damage induced by methylene dianiline inhibits oval cell activation.
Petersen, B. E., Zajac, V. F., & Michalopoulos, G. K. (1997) · PubMed · Cited by 89 · see citing works
Sell, S. (1978) · PubMed · Cited by 89 · see citing works
Laconi, S., Curreli, F., Diana, S., Pasciu, D., Filippo, G. D., Sarma, D. S. R., Pani, P., & Laconi, E. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80320-1 · Cited by 84 · see citing works
Evarts, R. P., Hu, Z., Omori, N., Omori, M., Marsden, E. R., & Thorgeirsson, S. S. (1996) · Carcinogenesis · doi:10.1093/carcin/17.10.2143 · Cited by 78 · see citing works
Paku, S., Dezső, K., Kopper, L., & Nagy, P. (2005) · Hepatology · doi:10.1002/hep.20858 · Cited by 63 · see citing works
Avril, A., Pichard, V., Bralet, M.-P., & Ferry, N. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.07.029 · Cited by 62 · see citing works
Sell, S., Leffert, H. L., Shinozuka, H., Lombardi, B., & Gochman, N. (1981) · PubMed · Cited by 59 · see citing works
Changes in albumin, α-fetoprotein and collagen gene transcription in ccl4-induced hepatic fibrosis
Panduro, A., Shalaby, F., Biempica, L., & Shafritz, D. A. (1988) · Hepatology · doi:10.1002/hep.1840080212 · Cited by 50 · see citing works
Gordon, G. J., Coleman, W. B., & Grisham, J. W. (2000) · Hepatology · doi:10.1053/jhep.2000.9144 · Cited by 44 · see citing works
Self-citationBest, D. H., & Coleman, W. B. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.01.040 · Cited by 35 · see citing works
Self-citationCorcelle, V., Stieger, B., Gjinovci, A., Wollheim, C. B., & Gauthier, B. R. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.05.007 · Cited by 32 · see citing works
Epithelial stem-like cells of the rodent liver
Coleman, W. B., & Grisham, J. W. (1998) · Springer eBooks · doi:10.1007/978-94-011-4932-7_3 · Cited by 29 · see citing works
Self-citationCharacterization and enrichment of hepatic progenitor cells in adult rat liver
Qin, A. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i10.1480 · Cited by 26 · see citing works
Cellular responses in experimental liver injury
Coleman, W. B., Best, D. H., Jaeschke, H., Mullen, K. D., & Moradpour, D. (2005) · Hepatology · doi:10.1002/hep.20685 · Cited by 14 · see citing works
Self-citationBest, D. H., & Coleman, W. B. (2010) · Molecular pathology library · doi:10.1007/978-1-4419-7107-4_17 · Cited by 8 · see citing works
Self-citation
Flagged first, then by citations
1 of the 34 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Hepatic stellate cells’ involvement in progenitor-mediated liver regeneration
Pintilie, D. G., Shupe, T. D., Oh, S., Salganik, S. V., Darwiche, H. A., & Petersen, B. E. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.88 · Cited by 74 · see citing works
Stem/progenitor cells in liver injury repair and regeneration
Zhao, Q., Ren, H., Zhu, D., & Han, Z. (2009) · Biology of the Cell · doi:10.1042/bc20080105 · Cited by 55 · see citing works
Tsuchida, T., Murata, S., Matsuki, K., Mori, A., Matsuo, M., Mikami, S., Okamoto, S., Ueno, Y., Tadokoro, T., Zheng, Y., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010178 · Cited by 41 · see citing works
Limaye, P. B., Bowen, W. C., Orr, A. V., Apte, U. M., & Michalopoulos, G. K. (2010) · Comparative Hepatology · doi:10.1186/1476-5926-9-9 · Cited by 36 · see citing works
Kon, J., Ichinohe, N., Ooe, H., Chen, Q., Sasaki, K., & Mitaka, T. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080338 · Cited by 33 · see citing works
Distinct hepatocyte identities in liver homeostasis and regeneration
Chen, F., Schönberger, K., & Tchorz, J. S. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100779 · Cited by 30 · see citing works
Chen, Y., Chang, M., Chien, C.-S., Wu, S., Yu, C.-H., & Chen, H. (2012) · Hepatology · doi:10.1002/hep.26104 · Cited by 24 · see citing works
Proliferation of rat small hepatocytes requires follistatin expression
Ooe, H., Chen, Q., Kon, J., Sasaki, K., Miyoshi, H., Ichinohe, N., Tanimizu, N., & Mitaka, T. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22971 · Cited by 14 · see citing works
Best, D. H., & Coleman, W. B. (2010) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2010.06.007 · Cited by 13 · see citing works
Self-citationBest, D. H., Butz, G. M., & Coleman, W. B. (2009) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2009.10.009 · Cited by 11 · see citing works
Self-citationPichard, V., Aubert, D., & Ferry, N. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007267 · Cited by 10 · see citing works
Best, D. H., & Coleman, W. B. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.11.002 · Cited by 9 · see citing works
Self-citationBest, D. H., & Coleman, W. B. (2010) · Molecular pathology library · doi:10.1007/978-1-4419-7107-4_17 · Cited by 8 · see citing works
Self-citationWang, Z., Li, W., Li, Q., Yang, Y., Li, W., Zhang, L., Sun, S., Li, J., & Cai, Y. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3675 · Cited by 7 · see citing works
Activation and Regulation of Reserve Liver Progenitor Cells
Best, D. H., & Coleman, W. B. (2011) · Vitamins and hormones · doi:10.1016/b978-0-12-386015-6.00026-3 · Cited by 5 · see citing works
Self-citationLian, R.-T., Zhuang, A.-Q., Yue, J., Chen, Y., Ma, K., & Wu, Y.-H. (2023) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x18666230125113254 · Cited by 4 · see citing works
Management of Liver Failure: From Transplantation to Cell-Based Therapy
Francipane, M. G., Cervello, M., Vizzini, G. B., Pietrosi, G., & Montalto, G. (2011) · Cell Medicine · doi:10.3727/215517911x575993 · Cited by 4 · see citing works
LIVER REGENERATION: SUMMARY OF INVOLVED CELL TYPES
Abdellatif, H. (2017) · Journal of Stem Cell and Regenerative Biology · doi:10.15436/2471-0598.17.021 · Cited by 3 · see citing works
Pichard, V., & Ferry, N. (2008)
Liver Stem-like Cells: Progenitor Cells for Liver Cancer?
Coleman, W. B. (2011)
Self-citation
- Authors
- Best, H. D., & Coleman, W. B.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Coleman, William B.
- ORCID
- Coleman, William B.
- Venue
- Hepatology
- Published
- 2007-11
- Volume
- 46
- Issue
- 5
- Pages
- 1611-1619
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W1982895923
- Cited by
- 21
- References
- 34
- Citations by year
- 2023: 2 · 2019: 1 · 2017: 1 · 2016: 1 · 2012: 1
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIH (CA 78343, T32 ES 07017)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- liver regeneration, partial hepatectomy, retrorsine, 4,4'-diaminodiphenylmethane, bile duct destruction, oval cells, liver progenitor cells, hepatocyte differentiation, cell of origin
- MeSH terms
- Aniline Compounds, Animals, Benzhydryl Compounds, Hepatectomy, Liver, Liver Regeneration, Male, Pyrrolizidine Alkaloids, Rats, Inbred F344, Stem Cells, Cell Proliferation, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
