Cited by 720Liver physiology and pathologyMesenchymal stem cell researchTissue Engineering and Regenerative Medicine

Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells

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Fausto, Nelson·2004·Hepatology

Abstract

tudies of liver regenerative processes have gained new prominence, generated from analyses of genetically engineered animal models, the transplantation of human livers, and the surging interest in stem cells.These studies gave rise to expectations regarding the practical applications of research on the mechanisms of liver regeneration that were unthinkable just a few years ago.As the field expanded to a broader audience, this new knowledge also brought confusion and often misinterpretations regarding the cellular mechanisms responsible for liver regeneration in different types of hepatic growth processes.This article is a brief review of the role of hepatocytes, oval cells (see box for nomenclature), and bone marrow cells in liver regeneration and repopulation.This topic has generated great excitement, a good deal of noise, much controversy, and many surprises.The review of the rapidly expanding literature presented here, particularly as it deals with stem cells, was guided by a few principles: (1) be wary of dogma 1 and of overinterpretation of data; (2) a "new discovery" may be a true new finding, but it may simply be the repackaging of an old discovery; and (3) an exciting story is not necessarily a true story.

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Crossref · 10.1002/hep.20214

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140 of 140 references verified0 citation errors · 0 not checkable

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  • Mature hepatocytes can enter the cell cycle and contribute to liver regeneration after partial hepatectomy.

    “mature hepatocytes are capable of entering the cell cycle and contribute to liver regeneration in the case of partial hepatectomy13.”

    From Molecular regulation of stem cell quiescence (2013) · cites this paper as [13]

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Research works printed but not linked: 4

  1. Sell S, Reynolds RD, Reutter W. Rat alpha 1-fetoprotein: appearance after galactosamine-induced liver injury. J Natl Cancer Inst 1974;53: 289 -291.
  2. Britt DE, Flanagan DL, Yang D, Hixson DC. Cloning of the rat oval cell/bile duct antigen OC.2. FASEB J 2003;17:665-667.
  3. Dabeva MD, Menthena A, Deb N, Guha C, Shafritz DA. Bone marrow progenitors are not the normal source of oval cells in the injured liver. FASEB J 2003;17:665.
  4. Sirica A. Ductular hepatocytes. Histol Histopathol 1995;10:433-456.

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Authors
Fausto, N.
Affiliations
University of Washington (US)
Corresponding author
Fausto, Nelson
Venue
Hepatology
Published
2004-06
Volume
39
Issue
6
Pages
1477-1487
ISSN
0270-9139 (ISSN-L)
OpenAlex
W2053820570
Cited by
720
References
140
Citations by year
2026: 4 · 2025: 4 · 2024: 6 · 2023: 21 · 2022: 16 · 2021: 23 · 2020: 22 · 2019: 18 · 2018: 40 · 2017: 35 · 2016: 25 · 2015: 40 · 2014: 41 · 2013: 39 · 2012: 45
FWCI
7.13
Type
journal article
Language
en
Open access
Locations
  • Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
liver regeneration, liver repair, hepatocytes, oval cells, hepatic progenitor cells, liver stem cells, bone marrow-derived cells, liver repopulation, liver transplantation, hepatocyte proliferation
MeSH terms
Animals, Bile Ducts, Bone Marrow Cells, Cell Differentiation, Cell Division, Cell Fusion, Hematopoietic Stem Cells, Humans, Liver, Liver Cirrhosis, Liver Neoplasms, Liver Regeneration, Necrosis, Phenotype, Stem Cells, Bone Marrow Transplantation, Liver Transplantation, Hepatocytes

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