Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells
Open accessAbstract
tudies of liver regenerative processes have gained new prominence, generated from analyses of genetically engineered animal models, the transplantation of human livers, and the surging interest in stem cells.These studies gave rise to expectations regarding the practical applications of research on the mechanisms of liver regeneration that were unthinkable just a few years ago.As the field expanded to a broader audience, this new knowledge also brought confusion and often misinterpretations regarding the cellular mechanisms responsible for liver regeneration in different types of hepatic growth processes.This article is a brief review of the role of hepatocytes, oval cells (see box for nomenclature), and bone marrow cells in liver regeneration and repopulation.This topic has generated great excitement, a good deal of noise, much controversy, and many surprises.The review of the rapidly expanding literature presented here, particularly as it deals with stem cells, was guided by a few principles: (1) be wary of dogma 1 and of overinterpretation of data; (2) a "new discovery" may be a true new finding, but it may simply be the repackaging of an old discovery; and (3) an exciting story is not necessarily a true story.
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Mature hepatocytes can enter the cell cycle and contribute to liver regeneration after partial hepatectomy.
“mature hepatocytes are capable of entering the cell cycle and contribute to liver regeneration in the case of partial hepatectomy13.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [13]
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1 retracted
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Human Liver-Derived Stem Cells
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Cells with neuroendocrine features in regenerating human liver.
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Hepatic regeneration from hematopoietic stem cells
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Progenitor cells of the biliary epithelial cell lineage
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Cells with neuroendocrine features in regenerating human liver
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Marrow to muscle, fission versus fusion
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Identification and propagation of liver stem cells
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Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes
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Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes
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c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity
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- Authors
- Fausto, N.
- Affiliations
- University of Washington (US)
- Corresponding author
- Fausto, Nelson
- Venue
- Hepatology
- Published
- 2004-06
- Volume
- 39
- Issue
- 6
- Pages
- 1477-1487
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2053820570
- Cited by
- 720
- References
- 140
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 21 · 2022: 16 · 2021: 23 · 2020: 22 · 2019: 18 · 2018: 40 · 2017: 35 · 2016: 25 · 2015: 40 · 2014: 41 · 2013: 39 · 2012: 45
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- liver regeneration, liver repair, hepatocytes, oval cells, hepatic progenitor cells, liver stem cells, bone marrow-derived cells, liver repopulation, liver transplantation, hepatocyte proliferation
- MeSH terms
- Animals, Bile Ducts, Bone Marrow Cells, Cell Differentiation, Cell Division, Cell Fusion, Hematopoietic Stem Cells, Humans, Liver, Liver Cirrhosis, Liver Neoplasms, Liver Regeneration, Necrosis, Phenotype, Stem Cells, Bone Marrow Transplantation, Liver Transplantation, Hepatocytes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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