The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Autophagy in the liver
Open accessAbstract
A great part of our current understanding of mammalian macroautophagy is derived from studies of the liver. The term “autophagy” was introduced by Christian de Duve in part based on ultrastructural changes in rat liver following glucagon injection. Subsequent morphological, biochemical, and kinetics studies of autophagy in the liver defined the basic process of autophagosome formation, maturation, and degradation and the regulation of autophagy by hormones, phosphoinositide 3-kinases, and mammalian target of rapamycin. It is now clear that macroautophagy in the liver is important for the balance of energy and nutrients for basic cell functions, the removal of misfolded proteins resulting from genetic mutations or pathophysiological stimulations, and the turnover of major subcellular organelles such as mitochondria, endoplasmic reticulum, and peroxisomes under both normal and pathophysiological conditions. Disturbance of autophagy function in the liver could thus have a major impact on liver physiology and liver disease.
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Cites
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
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The role of autophagy during the early neonatal starvation period
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Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412022 · Cited by 2,331
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Selective degradation of mitochondria by mitophagy
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Cited by
Terman, A., Kurz, T., Navratil, M., Arriaga, E. A., & Brunk, U. T. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2598 · Cited by 490
Hepatocyte Death: A Clear and Present Danger
Malhi, H., Guicciardi, M. E., & Gores, G. J. (2010) · Physiological Reviews · doi:10.1152/physrev.00061.2009 · Cited by 477
Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia
Liu, H.-Y., Han, J., Cao, S. Y., Hong, T., Zhuo, D., Shi, J., Liu, Z., & Cao, W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.033936 · Cited by 352
The emerging role of autophagy in the pathophysiology of diabetes mellitus
Gonzalez, C. D., Lee, M.-S., Marchetti, P., Pietropaolo, M., Towns, R., Vaccaro, M. I., Watada, H., & Wiley, J. W. (2011) · Autophagy · doi:10.4161/auto.7.1.13044 · Cited by 317
The molecular functions of hepatocyte nuclear factors – In and beyond the liver
Lau, H. H., Ng, N. H. J., Loo, L. S. W., Jasmen, J. B., & Teo, A. K. K. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2017.11.026 · Cited by 250
Metadata
- Authors
- Yin, X.-M., Ding, W.-X., & Gao, W.
- Venue
- Hepatology
- Published
- 2008-05
- Volume
- 47
- Issue
- 5
- Pages
- 1773-1785
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W1963837014
- Cited by
- 254
- References
- 16
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
