Functions of Lysosomes

de Duve, Christian; Wattiaux, Robert

doi:10.1146/annurev.ph.28.030166.002251

Cited by 3,033Cellular transport and secretionAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Functions of Lysosomes

de Duve, Christian, Wattiaux, Robert·1966·Annual Review of Physiology

DOI 10.1146/annurev.ph.28.030166.002251

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Uddin, M. S., Stachowiak, A., Mamun, A. A., Tzvetkov, N. T., Takeda, S., Atanasov, A. G., Bergantin, L. B., Abdel‐Daim, M. M., & Stankiewicz, A. M. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00004 · Cited by 440 · see citing works
“Keywords: autophagy, Alzheimer’s disease, amyloid beta, tau INTRODUCTION Introduced to biology in 1963 by Belgian biochemist Christian de Duve (De Duve and Wattiaux, 1966) autophagy (from Greek “self-eating”) is an intracellular self-degradative process that is responsible for the systematic…”
Background
Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain.
Cataldo, A., & Nixon, R. (1990) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.87.10.3861 · Cited by 436 · see citing works
Membrane fusion
Poste, G. H., & ALLISON, A. C. (1973) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(73)90015-4 · Cited by 436 · see citing works
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer’s disease ameliorates amyloid pathologies and memory deficits
Yang, D.-S., Stavrides, P., Mohan, P. S., Kaushik, S., Kumar, A., Ohno, M., Schmidt, S. D., Wesson, D., Bandyopadhyay, U., Jiang, Y., et al. (2011) · Brain · doi:10.1093/brain/awq341 · Cited by 429 · see citing works
“Lysosomes (DeDuve and Wattiaux, 1966) are acidified vesicular”
Cysteine cathepsins: Cellular roadmap to different functions
Brix, K., Dunkhorst, A., Mayer, K., & Jordans, S. (2007) · Biochimie · doi:10.1016/j.biochi.2007.07.024 · Cited by 428 · see citing works
Endosomes
Helenius, A., Mellman, I., Wall, D. A., & Hubbard, A. L. (1983) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(83)90350-x · Cited by 428 · see citing works
Innate and Adaptive Immunity through Autophagy
Schmid, D., & Münz, C. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.004 · Cited by 461 · see citing works
“For lysosomes, autophagy delivers intracellular constituents for degradation, but how autophagosome cargo is selected remains unclear (De Duve and Wattiaux, 1966) .”
Background
The New Biology and Pharmacology of Glucagon
Müller, T. D., Finan, B., Clemmensen, C., DiMarchi, R. D., & Tschöp, M. H. (2017) · Physiological Reviews · doi:10.1152/physrev.00025.2016 · Cited by 419 · see citing works
“The presence and quantity of acid hydrolases in these organelles, which were appropriately named lysosomes, pointed to a role in cellular autophagy (133, 143), which was later confirmed experimentally (179).”
Background
Green and facile synthesis of highly biocompatible graphene nanosheets and its application for cellular imaging and drug delivery
Liu, K., Zhang, J., Cheng, F.-F., Zheng, T., Wang, C., & Zhu, J. (2011) · Journal of Materials Chemistry · doi:10.1039/c1jm10749f · Cited by 413 · see citing works
Autophagy and other vacuolar protein degradation mechanisms
Seglen, P. O., & Bohley, P. (1992) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923509 · Cited by 405 · see citing works
Regulation and Function of Autophagy during Cell Survival and Cell DeathPreprint
Das, G., Shravage, B. V., & Baehrecke, E. H. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008813 · Cited by 413 · see citing works
“…be initiated from a membrane source known as the phagophore assembly site (PAS). de Duve suggested that the smooth endoplasmic reticulum could be the source of autophagosome membrane (de Duve and Wattiaux 1966), and subsequent studies have supported this possibility (Dunn 1990; Axe et al. 2008).”
Result

Authors: de Duve, C., & Wattiaux, R.
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 1966-03
Volume: 28
Issue: 1
Pages: 435-492
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev.ph.28.030166.002251
OpenAlex: W2138948114
Cited by: 3,033
References: 0
Citations by year: 2026: 25 · 2025: 56 · 2024: 58 · 2023: 50 · 2022: 47 · 2021: 75 · 2020: 68 · 2019: 54 · 2018: 79 · 2017: 65 · 2016: 70 · 2015: 63 · 2014: 64 · 2013: 64 · 2012: 51
FWCI: 111.33
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords: lysosomes, lysosomal function, intracellular digestion, acid hydrolases, membrane trafficking, endocytosis, autophagy
MeSH terms: Animals, Lysosomes, In Vitro Techniques

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