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The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia

Liu, Hui-Yu, Han, Jianmin, Cao, Sophia Y., Hong, Tao, Zhuo, Degen, Shi, Jianbo, Liu, Zhenqi, Cao, Wenhong·2009·Journal of Biological Chemistry
DOI 10.1074/jbc.m109.033936
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Abstract

Autophagy is essential for maintaining both survival and health of cells. Autophagy is normally suppressed by amino acids and insulin. It is unclear what happens to the autophagy activity in the presence of insulin resistance and hyperinsulinemia. In this study, we examined the autophagy activity in the presence of insulin resistance and hyperinsulinemia and the associated mechanism. Insulin resistance and hyperinsulinemia were induced in mice by a high fat diet, followed by measurements of autophagy markers. Our results show that autophagy was suppressed in the livers of mice with insulin resistance and hyperinsulinemia. Transcript levels of some key autophagy genes were also suppressed in the presence of insulin resistance and hyperinsulinemia. Conversely, autophagy activity was increased in the livers of mice with streptozotocin-induced insulin deficiency. Levels of vps34, atg12, and gabarapl1 transcripts were elevated in the livers of mice with insulin deficiency. To study the mechanism, autophagy was induced by nutrient deprivation or glucagon in cultured hepatocytes in the presence or absence of insulin. Autophagy activity and transcript levels of vps34, atg12, and gabarapl1 genes were reduced by insulin. The effect of insulin was largely prevented by overexpression of the constitutive nuclear form of FoxO1. Importantly, autophagy of mitochondria (mitophagy) in cultured cells was suppressed by insulin in the presence of insulin resistance. Together, our results show tha…

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Metadata

Authors
Liu, H.-Y., Han, J., Cao, S. Y., Hong, T., Zhuo, D., Shi, J., Liu, Z., & Cao, W.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2009-11
Volume
284
Issue
45
Pages
31484-31492
ISSN
0021-9258
DOI
10.1074/jbc.m109.033936
Cited by
352
References
6
Language
en
Licence

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