The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
IMMUNOBIOLOGY AND PATHOGENESIS OF VIRAL HEPATITIS
Abstract
Among the many viruses that are known to infect the human liver, hepatitis B virus (HBV) and hepatitis C virus (HCV) are unique because of their prodigious capacity to cause persistent infection, cirrhosis, and liver cancer. HBV and HCV are noncytopathic viruses and, thus, immunologically mediated events play an important role in the pathogenesis and outcome of these infections. The adaptive immune response mediates virtually all of the liver disease associated with viral hepatitis. However, it is becoming increasingly clear that antigen-nonspecific inflammatory cells exacerbate cytotoxic T lymphocyte (CTL)-induced immunopathology and that platelets enhance the accumulation of CTLs in the liver. Chronic hepatitis is characterized by an inefficient T cell response unable to completely clear HBV or HCV from the liver, which consequently sustains continuous cycles of low-level cell destruction. Over long periods of time, recurrent immune-mediated liver damage contributes to the development of cirrhosis and hepatocellular carcinoma.
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Cites
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The proinflammatory mediators C3a and C5a are essential for liver regeneration
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Cited by
Redefining Chronic Viral Infection
Virgin, H. W., Wherry, E. J., & Ahmed, R. (2009) · Cell · doi:10.1016/j.cell.2009.06.036 · Cited by 1,031
Persistent LCMV infection is controlled by blockade of type I interferon signaling
Teijaro, J. R., Ng, C., Lee, A. M., Sullivan, B. M., Sheehan, K. C. F., Welch, M., Schreiber, R. D., Carlos de la Torre, J., & Oldstone, M. B. A. (2013) · Science · doi:10.1126/science.1235214 · Cited by 755
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Immunobiology and pathogenesis of hepatitis B virus infection
Iannacone, M., & Guidotti, L. G. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00549-4 · Cited by 520
Self-citationPathogenesis of hepatitis B virus infection
Chisari, F. V., Isogawa, M., & Wieland., S. F. (2010) · Pathologie Biologie · doi:10.1016/j.patbio.2009.11.001 · Cited by 414
Self-citation
Metadata
- Authors
- Guidotti, L. G., & Chisari, F. V.
- Venue
- Annual Review of Pathology: Mechanisms of Disease
- Publisher
- Annual Reviews
- Published
- 2006-02-01
- Volume
- 1
- Issue
- 1
- Pages
- 23-61
- ISSN
- 1553-4006 (ISSN-L)
- 1553-4014
- OpenAlex
- W2131605289
- Cited by
- 811
- References
- 10
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: IMMUNOBIOLOGY AND PATHOGENESIS OF VIRAL HEPATITIS. https://app.cochat.ai/papers/10.1146/annurev.pathol.1.110304.100230
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- Guidotti, L. G., & Chisari, F. V. (2006). IMMUNOBIOLOGY AND PATHOGENESIS OF VIRAL HEPATITIS. Annual Review of Pathology: Mechanisms of Disease. https://doi.org/10.1146/annurev.pathol.1.110304.100230
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
