The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Reassessing selection criteria prior to liver transplantation for hepatocellular carcinoma utilizing the scientific registry of transplant recipients database†‡
Open accessAbstract
The current model of liver graft allocation in place in the United States favors transplantation of patients with small hepatocellular carcinomas (HCCs) within the Milan criteria (a single tumor up to 5 cm in diameter or up to three lesions, none larger than 3 cm). Although several reports have suggested that these criteria could be extended, there is currently no agreement on new selection tools. In this study, we performed an overview of 6478 adult recipients of an isolated first liver transplant registered in the Scientific Registry of Transplant Recipients (SRTR) database. From March 2002 to January 2008, increasing numbers of patients outside Milan criteria (P ≤ 0.001) have been registered for a transplant, but they still represent less than 5% of the transplants performed for HCC. Of all the tested variables (tumor number, largest tumor size, and Milan and University of California San Francisco criteria), only total tumor volume (TTV; P ≤ 0.05) and alpha fetoprotein (AFP; P ≤ 0.001) could predict patient survival. While these two parameters demonstrated independent behaviors (no patient demonstrated an increase in both values), a composite score was defined, with patients with a TTV > 115 cm3 or an AFP > 400 ng/mL being outside criteria. The combined TTV/AFP score efficiently predicted posttransplant survival (hazard ratio = 2, 95% confidence interval = 1.7-2.4, P ≤ 0.001); patients not meeting these criteria had a survival below 50% at 3 years. Conclusion: According to the present SRTR data, Milan criteria are too restrictive, and patients with larger TTV can enjoy satisfactory posttransplant survivals. A composite patient selection score combining TTV and AFP was the most effective of all tested staging criteria for the prediction of posttransplant patient survival for candidates with HCC. (HEPATOLOGY 2009.)
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1 retracted
Liver Transplantation for Hepatocellular Carcinoma: Hangzhou Experiences [RETRACTED]
Zheng, S.-S., Xu, X., Wu, J., Chen, J., Wang, W.-L., Zhang, M., Liang, T.-B., & Wu, L.-M. (2008) · Transplantation · doi:10.1097/tp.0b013e31816b67e4 · Cited by 452
RetractedMazzaferro, V., Regalia, E., Doci, R., Andreola, S., Pulvirenti, A., Bozzetti, F., Montalto, F., Ammatuna, M., Morabito, A., & Gennari, L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603143341104 · Cited by 7,186
Yao, F. Y., Ferrell, L., Bass, N. M., Watson, J. J., Bacchetti, P., Venook, A., Ascher, N. L., & Roberts, J. P. (2001) · Hepatology · doi:10.1053/jhep.2001.24563 · Cited by 2,262
Jonas, S., Bechstein, W. O., Steinmüller, T., Herrmann, M., Radke, C., Berg, T., Settmacher, U., & Neuhaus, P. (2001) · Hepatology · doi:10.1053/jhep.2001.23561 · Cited by 894
Yao, F. Y., Xiao, L., Bass, N. M., Kerlan, R., Ascher, N. L., & Roberts, J. P. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.01965.x · Cited by 562
Recurrence of hepatocellular carcinoma after liver transplant: Patterns and prognosis
Roayaie, S., Schwartz, J. D., Sung, M. W., Emre, S. H., Miller, C. M., Gondolesi, G. E., Krieger, N. R., & Schwartz, M. E. (2004) · Liver Transplantation · doi:10.1002/lt.20128 · Cited by 455
Duffy, J. P., Vardanian, A., Benjamin, E., Watson, M., Farmer, D. G., Ghobrial, R. M., Lipshutz, G., Yersiz, H., Lu, D. S. K., Lassman, C., et al. (2007) · Annals of Surgery · doi:10.1097/sla.0b013e318148c704 · Cited by 445
Lee, S.-G., Hwang, S., Moon, D.-B., Ahn, C.-S., Kim, K.-H., Sung, K.-B., Ko, G.-Y., Park, K.-M., Ha, T.-Y., & Song, G.-W. (2008) · Liver Transplantation · doi:10.1002/lt.21445 · Cited by 330
Liver Transplantation for Hepatocellular Carcinoma
Mazzaferro, V., Chun, Y. S., Poon, R. T. P., Schwartz, M., Yao, F. Y., Marsh, J. W., Bhoori, S., & Lee, S. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-007-9559-5 · Cited by 317
Ito, T., Takada, Y., Ueda, M., Haga, H., Maetani, Y., Oike, F., Ogawa, K., Sakamoto, S., Ogura, Y., Egawa, H., et al. (2007) · Liver Transplantation · doi:10.1002/lt.21281 · Cited by 240
Cited by
EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma
Galle, P. R., Forner, A., Llovet, J. M., Mazzaferro, V., Piscaglia, F., Raoul, J.-L., Schirmacher, P., & Vilgrain, V. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.03.019 · Cited by 11,406
EASL Clinical Practice Guidelines on the management of hepatocellular carcinoma
Sangro, B., Argemi, J., Ronot, M., Paradis, V., Meyer, T., Mazzaferro, V., Jepsen, P., Golfieri, R., Galle, P., Dawson, L., et al. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2024.08.028 · Cited by 985
Mazzaferro, V., Bhoori, S., Sposito, C., Bongini, M., Langer, M., Miceli, R., & Mariani, L. (2011) · Liver Transplantation · doi:10.1002/lt.22365 · Cited by 593
Toso, C., Merani, S., Bigam, D. L., Shapiro, A. M. J., & Kneteman, N. M. (2010) · Hepatology · doi:10.1002/hep.23437 · Cited by 329
Self-citationHameed, B., Mehta, N., Sapisochin, G., Roberts, J. P., & Yao, F. Y. (2014) · Liver Transplantation · doi:10.1002/lt.23904 · Cited by 279
Metadata
- Authors
- Toso, C., Asthana, S., Bigam, D. L., Shapiro, A. M. J., & Kneteman, N. M.
- Venue
- Hepatology
- Published
- 2009-03
- Volume
- 49
- Issue
- 3
- Pages
- 832-838
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W1988475496
- Cited by
- 332
- References
- 17
- FWCI
- 11.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Toso, C., Asthana, S., Bigam, D. L., Shapiro, A. M. J., & Kneteman, N. M. (2009). Reassessing selection criteria prior to liver transplantation for hepatocellular carcinoma utilizing the scientific registry of transplant recipients database†‡. Hepatology. https://doi.org/10.1002/hep.22693
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