Mechanistic insights into immunomodulation by hepatic stellate cells in mice: A critical role of interferon‐γ signaling†
Open accessAbstract
UNLABELLED: The liver is considered to be an immune-privileged organ that favors the induction of tolerance. The underlying mechanisms are not completely understood. Interestingly, liver transplants are spontaneously accepted in several animal models, but hepatocyte transplants are acutely rejected, suggesting that liver nonparenchymal cells may effectively protect the parenchymal cells from immune attack. We have shown the profound T cell inhibitory activity of hepatic stellate cells (HSCs). Thus, cotransplantation with HSCs effectively protects islet allografts from rejection in mice. In this study, using T cell receptor transgenic and gene knockout approaches, we provided definitive evidence that HSCs protected cotransplanted islet allografts by exerting comprehensive inhibitory effects on T cells, including apoptotic death in graft-infiltrating antigen-specific effector T cells and marked expansion of CD4(+) Forkhead box protein (Foxp)3(+) T regulatory (Treg) cells. All these effects required an intact interferon-gamma (IFN-gamma) signaling in HSCs, demonstrated by using HSCs isolated from IFN-gamma receptor 1 knockout mice. B7-H1 expression on HSCs, a product molecule of IFN-gamma signaling, was responsible for induction of T cells apoptosis, but had no effect on expansion of Treg cells, suggesting that undetermined effector molecules produced by IFN-gamma signaling is involved in this process. CONCLUSION: Upon inflammatory stimulation, specific organ stromal cells (such as HSCs in the liver) demonstrate potent immune regulatory activity. Understanding of the mechanisms involved may lead to development of novel strategies for clinical applications in transplantation and autoimmune diseases.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A sizeable proportion, between 23% and 48%, of patients with MASLD and/or MASH were found to exhibit signs of AIH and/or PBC, including interface hepatitis and generation of anti-nuclear or anti-mitochondrial antibodies.
“In the small number of investigations performed, a sizeable proportion (between 23% and 48%) of patients with MASLD and/or MASH were found to exhibit signs of AIH and/or PBC, including interface hepatitis and generation of anti-nuclear (ANA) or anti-mitochondrial (AMA) antibodies (38-40).”
From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [38]
The Introduction and Results describe hepatic stellate cells and islet allografts in mice, not patients with MASLD or MASH. Searches for the 23%–48% range, interface hepatitis, AIH/PBC, and ANA/AMA found no passage addressing the claimed patient findings. The cited paper therefore does not verify this claim. (LLM, conf=0.78)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Regulatory T Cells and Immune Tolerance
Sakaguchi, S., Yamaguchi, T., Nomura, T., & Ono, M. (2008) · Cell · doi:10.1016/j.cell.2008.05.009 · Cited by 5,357 · see citing works
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., et al. (2002) · Nature Medicine · doi:10.1038/nm730 · Cited by 5,025 · see citing works
Mechanisms of type-I- and type-II-interferon-mediated signalling
Platanias, L. C. (2005) · Nature reviews. Immunology · doi:10.1038/nri1604 · Cited by 3,480 · see citing works
Vignali, D. A. A., Collison, L. W., & Workman, C. J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2343 · Cited by 3,463 · see citing works
Zheng, S. G., Wang, J., Wang, P., Gray, J. D., & Horwitz, D. A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2018 · Cited by 597 · see citing works
The liver as an immunological organ
Weiler-Normann, C., & Rehermann, B. (2004) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2004.03687.x · Cited by 595 · see citing works
Immunoregulatory function of mesenchymal stem cells
Uccelli, A., Moretta, L., & Pistoia, V. (2006) · European Journal of Immunology · doi:10.1002/eji.200636416 · Cited by 558 · see citing works
Erratum: Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
Dong, H., Strome, S. E., Salomão, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., et al. (2002) · Nature Medicine · doi:10.1038/nm0902-1039c · Cited by 545 · see citing works
Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells
Davidson, T. S., DiPaolo, R. J., Andersson, J., & Shevach, E. M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4022 · Cited by 520 · see citing works
Interferon γ Is Required for Activation-induced Death of T Lymphocytes
Refaeli, Y., Parijs, L. V., Alexander, S. I., & Abbas, A. K. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020666 · Cited by 415 · see citing works
Clinical islet transplantation: advances and immunological challenges
Ricordi, C., & Strom, T. (2004) · Nature reviews. Immunology · doi:10.1038/nri1332 · Cited by 396 · see citing works
Qian, S., Lu, L., Fu, F., Li, Y., Li, W., Starzl, T. E., Fung, J. J., & Thomson, A. W. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.10.4654 · Cited by 301 · see citing works
Self-citationInhibition of T–Cell Responses by Hepatic Stellate Cells Via B7–H1-Mediated T–Cell Apoptosis in Mice
Yu, M., Chen, C., Liang, X., Wang, L., Gandhi, C. R., Fung, J. J., Lu, L., & Qian, S. (2004) · Hepatology · doi:10.1002/hep.20488 · Cited by 301 · see citing works
Self-citationCellular and molecular mechanisms of liver tolerance
Crispe, I. N., Giannandrea, M., Klein, I., John, B., Sampson, B. C., & Wuensch, S. A. (2006) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00435.x · Cited by 234 · see citing works
B7-H1-Induced Apoptosis as a Mechanism of Immune Privilege of Corneal Allografts
Hori, J., Wang, M., Miyashita, M., Tanemoto, K., Takahashi, H., Takemori, T., Okumura, K., Yagita, H., & Azuma, M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.5928 · Cited by 208 · see citing works
Interferon γ: a crucial role in the function of induced regulatory T cells in vivo
Wood, K. J., & Sawitzki, B. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.02.008 · Cited by 207 · see citing works
Sun, Y., Lin, X., Chen, H. M., Wu, Q., Subudhi, S. K., Chen, L., & Fu, Y. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.3.1457 · Cited by 189 · see citing works
Kelchtermans, H., Klerck, B. D., Mitera, T., Balen, M. V., Bullens, D. M. A., Billiau, A., Leclercq, G., & Matthys, P. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1500 · Cited by 161 · see citing works
In Vivo Immune Modulatory Activity of Hepatic Stellate Cells in Mice
Chen, C.-H., Kuo, L.-M., Chang, Y., Wu, W., Goldbach, C., Ross, M. A., Stolz, D. B., Chen, L., Fung, J. J., Lu, L., et al. (2006) · Hepatology · doi:10.1002/hep.21379 · Cited by 154 · see citing works
Self-citationJiang, G., Yang, H.-R., Wang, L., Wildey, G. M., Fung, J., Qian, S., & Lu, L. (2008) · Transplantation · doi:10.1097/tp.0b013e31818bfd13 · Cited by 96 · see citing works
Self-citationA FUNCTIONAL MODEL OF HEPATOCYTE TRANSPLANTATION FOR IN VIVO IMMUNOLOGIC STUDIES1,2
Bumgardner, G. L., Heininger, M., Li, J., Xia, D., Parker‐Thornburg, J., Ferguson, R. M., & Orosz, C. G. (1998) · Transplantation · doi:10.1097/00007890-199801150-00011 · Cited by 73 · see citing works
Yu, X., Albert, M. H., Martin, P. J., & Anasetti, C. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20940 · Cited by 69 · see citing works
Korbutt, G. S., Suarez‐Pinzon, W. L., Power, R. F., Rajotte, R. V., & Rabinovitch, A. (2000) · Diabetologia · doi:10.1007/s001250051331 · Cited by 63 · see citing works
IFN‐γ is an Absolute Requirement for Spontaneous Acceptance of Liver Allografts
Mele, T. S., Kneteman, N. M., Zhu, L., Ramassar, V., Urmson, J. R., Halloran, B. P., Churchill, T. A., Jewell, L. D., Kane, K. P., & Halloran, P. F. (2003) · American Journal of Transplantation · doi:10.1034/j.1600-6143.2003.00153.x · Cited by 58 · see citing works
Verbinnen, B., Billiau, A., Vermeiren, J., Galicia, G., Bullens, D. M. A., Boon, L., Cadot, P., Hens, G., Dewolf-Peeters, C., Gool, S. W. V., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.2.1034 · Cited by 50 · see citing works
Asavaroengchai, W., Wang, H., Wang, S., Wang, L., Bronson, R. T., Sykes, M., & Yang, Y. (2007) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2006.09.014 · Cited by 42 · see citing works
Self-citationInstruction of Treg commitment in peripheral T cells is suited to reverse autoimmunity
Jaeckel, E., Kretschmer, K., Apostolou, I., & von Boehmer, H. (2006) · Seminars in Immunology · doi:10.1016/j.smim.2006.01.011 · Cited by 30 · see citing works
Qian, S., Thai, N., Lü, L., Fung, J. J., & Thomson, A. W. (1997) · Transplantation Reviews · doi:10.1016/s0955-470x(97)80015-8 · Cited by 29 · see citing works
Self-citationIFN-γ Mediates the Death of Th1 Cells in a Paracrine Manner
Foulds, K. E., Rotte, M. J., Paley, M., Singh, B., Douek, D. C., Hill, B. J., O’Shea, J. J., Watford, W. T., Seder, R. A., & Wu, C. Y. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.2.842 · Cited by 25 · see citing works
Reding, R., & DAVIES, H. F. S. (2004) · Liver Transplantation · doi:10.1002/lt.20171 · Cited by 14 · see citing works
Regulation and privilege in transplantation
Waldmann, H. (2007) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e32821f6084 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [13]Mele TS Kneteman NM Zhu LF IFN-γ is an absolute requirement for spontaneous acceptance of liver allografts Am J Transplant 2003 3 942 951 12859528
- [15]Zheng SG Wang J Wang P Gray JD Horwitz DA IL-2 is essential for TGF-β to convert naive CD4+ Cells. J Immunol 2007 178 2018 2027 17277105
Cited by
Sorted by citations
Antigen-presenting cell function in the tolerogenic liver environment
Thomson, A. W., & Knolle, P. A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2858 · Cited by 804 · see citing works
Mesenchymal Cells of the Intestinal Lamina Propria
Powell, D. W., Pinchuk, I. V., Saada, J. I., Chen, X., & Mifflin, R. C. (2011) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100646 · Cited by 388 · see citing works
Immunity, tolerance and autoimmunity in the liver: A comprehensive review
Doherty, D. G. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.08.020 · Cited by 313 · see citing works
Immune tolerance in liver disease
Crispe, I. N. (2014) · Hepatology · doi:10.1002/hep.27254 · Cited by 277 · see citing works
Weiskirchen, R., & Tacke, F. (2014) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2304-3881.2014.11.03 · Cited by 269 · see citing works
Immunomodulatory Properties of Mesenchymal Stem Cells: Cytokines and Factors
Soleymaninejadian, E., Pramanik, K., & Samadian, E. (2011) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2011.01069.x · Cited by 238 · see citing works
Aoyama, T., Inokuchi, S., Brenner, D. A., & Seki, E. (2010) · Hepatology · doi:10.1002/hep.23795 · Cited by 211 · see citing works
Bailey, C. M., Liu, Y., Liu, M., Du, X., Devenport, M., Zheng, P., Liu, Y., & Wang, Y. (2022) · Journal of Clinical Investigation · doi:10.1172/jci150846 · Cited by 151 · see citing works
Dara, L., Liu, Z., & Kaplowitz, N. (2015) · Liver International · doi:10.1111/liv.12988 · Cited by 140 · see citing works
Chou, H.-S., Hsieh, C., Yang, H.-R., Wang, L., Arakawa, Y., Brown, K., Wu, Q., Lin, F., Peters, M. G., Fung, J. J., et al. (2011) · Hepatology · doi:10.1002/hep.24162 · Cited by 126 · see citing works
Self-citationLiu, Z., McMichael, E. L., Shayan, G., Li, J., Chen, K., Srivastava, R., Kane, L., Lu, B., & Ferris, R. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-1350 · Cited by 104 · see citing works
Chou, H.-S., Hsieh, C., Charles, R., Wang, L., Wagner, T., Fung, J. J., Qian, S., & Lu, L. L. (2011) · Transplantation · doi:10.1097/tp.0b013e31823ffd39 · Cited by 105 · see citing works
Self-citationMechanisms of immune checkpoint inhibitor-mediated liver injury
Shojaie, L., Ali, M., Iorga, A., & Dara, L. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.10.003 · Cited by 98 · see citing works
The role of complement component 3 (C3) in differentiation of myeloid-derived suppressor cells
Hsieh, C., Chou, H.-S., Yang, H.-R., Lin, F., Bhatt, S., Qin, J., Wang, L., Fung, J. J., Qian, S., & Lü, L. (2013) · Blood · doi:10.1182/blood-2012-06-440214 · Cited by 94 · see citing works
Self-citationThe liver works as a school to educate regulatory immune cells
Li, F., & Tian, Z. (2013) · Cellular and Molecular Immunology · doi:10.1038/cmi.2013.7 · Cited by 92 · see citing works
Heart Transplantation: Challenges Facing the FieldPreprint
Tonsho, M., Michel, S., Ahmed, Z., Alessandrini, A., & Madsen, J. C. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015636 · Cited by 91 · see citing works
Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism
Schildberg, F. A., Wojtalla, A., Siegmund, S. V., Endl, E., Diehl, L., Abdullah, Z., Kurts, C., & Knolle, P. A. (2011) · Hepatology · doi:10.1002/hep.24352 · Cited by 90 · see citing works
Human Hepatic Stellate Cells Inhibit T-Cell Response Through B7-H1 Pathway
Charles, R., Chou, H.-S., Wang, L., Fung, J. J., Lu, L., & Qian, S. (2013) · Transplantation · doi:10.1097/tp.0b013e318294caae · Cited by 72 · see citing works
Self-citationKuang, P., Zhao, W., Su, W.-X., Zhang, Z., Zhang, L., Liu, J., Ren, G., Yin, Z., & Wang, X. (2012) · International Journal of Cancer · doi:10.1002/ijc.27852 · Cited by 60 · see citing works
Wang, H., & Yang, Y. (2014) · Immunological Reviews · doi:10.1111/imr.12151 · Cited by 59 · see citing works
Hsieh, C., Hung, C., Chiang, M., Tsai, Y.-C., & He, J.-T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205079 · Cited by 56 · see citing works
Xie, L., Ichimaru, N., Morita, M., Chen, J., Zhu, P., Wang, J., Urbanellis, P., Shalev, I., Nagao, S., Sugioka, A., et al. (2011) · Liver Transplantation · doi:10.1002/lt.22480 · Cited by 54 · see citing works
Organ-specific Differences in Achieving Tolerance
Madariaga, M., Kreisel, D., & Madsen, J. (2015) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000206 · Cited by 49 · see citing works
The liver as a central "hub" of the immune system: pathophysiological implications
Ronca, V., Gerussi, A., Collins, P., Parente, A., Oo, Y. H., & Invernizzi, P. (2025) · Physiological Reviews · doi:10.1152/physrev.00004.2023 · Cited by 59 · see citing works
ZHAO, W., SU, W., KUANG, P., ZHANG, L., LIU, J., YIN, Z., & WANG, X. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1497 · Cited by 51 · see citing works
Raicevic, G., Najar, M., Najimi, M., Taghdouini, A. E., van Grunsven, L. A., Sokal, E. M., & Toungouz, M. (2014) · Cytotherapy · doi:10.1016/j.jcyt.2014.10.001 · Cited by 51 · see citing works
Presentation of hepatocellular antigens
Grakoui, A., & Crispe, I. N. (2016) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.109 · Cited by 50 · see citing works
Li, Y., Kim, B.-G., Qian, S., Letterio, J. J., Fung, J. J., Lu, L., & Lin, F. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500139 · Cited by 45 · see citing works
Self-citationCotransplantation With Myeloid-Derived Suppressor Cells Protects Cell Transplants
Arakawa, Y., Qin, J., Chou, H.-S., Bhatt, S., Wang, L., Stuehr, D. J., Ghosh, A., Fung, J. J., Lü, L., & Qian, S. (2014) · Transplantation · doi:10.1097/01.tp.0000442504.23885.f7 · Cited by 40 · see citing works
Self-citationMorita, M., Joyce, D. P., Miller, C. M., Fung, J. J., Lü, L., & Qian, S. (2015) · Hepatology · doi:10.1002/hep.27909 · Cited by 38 · see citing works
Self-citationThe roles of myeloid-derived suppressor cells in transplantation
Wu, T., Zhao, Y., & Zhao, Y. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.948424 · Cited by 34 · see citing works
Bomble, M., Tacke, F., Rink, L., Kovalenko, E., & Weiskirchen, R. (2010) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2010.04.094 · Cited by 42 · see citing works
The role of the liver in the migration of parasites of global significance
Deslyper, G., Doherty, D., Carolan, J., & Holland, C. (2019) · Parasites & Vectors · doi:10.1186/s13071-019-3791-2 · Cited by 30 · see citing works
Chen, W., Yan, X., Yang, A., Xu, A., Huang, T., & You, H. (2019) · Epigenomics · doi:10.2217/epi-2019-0104 · Cited by 31 · see citing works
Hepatic Stellate Cells Directly Inhibit B Cells via Programmed Death–Ligand 1
Li, Y., Lu, L., Qian, S., Fung, J. J., & Lin, F. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501737 · Cited by 29 · see citing works
Self-citationTransplantation tolerance and its outcome during infections and inflammation
Chong, A. S., & Alegre, M. (2014) · Immunological Reviews · doi:10.1111/imr.12147 · Cited by 29 · see citing works
Hepatic immune tolerance induced by hepatic stellate cells
Hsieh, C. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i42.11887 · Cited by 28 · see citing works
Regulation of Drug Metabolizing Enzymes and Transporters in Infection, Inflammation, and Cancer
Morgan, E. T., Lee, C., & Nyagode, B. A. (2012) · Encyclopedia of Drug Metabolism and Interactions · doi:10.1002/9780470921920.edm089 · Cited by 28 · see citing works
Madariaga, M. L. L., Michel, S. G., Tasaki, M., Villani, V., Muraglia, G. M. L., Sihag, S., Gottschall, J. D., Farkash, E. A., Shimizu, A., Allan, J. S., et al. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12423 · Cited by 27 · see citing works
Immunological aspects of liver cell transplantation
Oldhafer, F., Bock, M., Falk, C. S., & Vondran, F. W. R. (2016) · World Journal of Transplantation · doi:10.5500/wjt.v6.i1.42 · Cited by 27 · see citing works
Qin, J., Arakawa, Y., Morita, M., Fung, J. J., Qian, S., & Lü, L. (2016) · Transplantation · doi:10.1097/tp.0000000000001529 · Cited by 27 · see citing works
Self-citationHepatic immune regulation by stromal cells
Schildberg, F. A., Sharpe, A. H., & Turley, S. J. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.10.002 · Cited by 25 · see citing works
The Role Of Hepatic Stellate Cells In Promoting Liver Metastasis Of Colorectal Carcinoma
Huang, W., Zhou, M., Zhu, Y., Xiang, J., Li, Z., Wang, Z.-H., Zhou, Y., Yang, Y., Chen, Z., & Gu, X. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s214409 · Cited by 24 · see citing works
Self-citationRole of Hepatocyte Growth Factor in the Immunomodulation Potential of Amniotic Fluid Stem Cells
Maraldi, T., Beretti, F., Guida, M., Zavatti, M., & Pol, A. D. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0266 · Cited by 24 · see citing works
Why some organ allografts are tolerated better than others: new insights for an old question
Hull, T. D., Bénichou, G., & Madsen, J. C. (2018) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000594 · Cited by 24 · see citing works
Sällberg, M., & Pasetto, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00552 · Cited by 22 · see citing works
Oh, J. Y., Kim, E. J., Yun, Y. I., & Lee, R. H. (2021) · The Ocular Surface · doi:10.1016/j.jtos.2021.02.002 · Cited by 16 · see citing works
O death where is thy sting? Immunologic tolerance to apoptotic self
Ravishankar, B., & McGaha, T. L. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1261-0 · Cited by 15 · see citing works
Tolerance-Inducing Strategies in Islet Transplantation
Bhatt, S., Fung, J. J., Lü, L., & Qian, S. (2012) · International Journal of Endocrinology · doi:10.1155/2012/396524 · Cited by 15 · see citing works
Self-citationOran, D. C., Lokumcu, T., Inceoglu, Y., Akolpoglu, M. B., Albayrak, Ö., Bal, T., Kurtoğlu, M., Erkan, M., Can, F., Onder, T. B., et al. (2019) · Materials Today Bio · doi:10.1016/j.mtbio.2019.100006 · Cited by 15 · see citing works
Gosemann, J., Kuebler, J. F., Pozzobon, M., Neunaber, C., Hensel, J. H. K., Ghionzoli, M., Coppi, P. D., Ure, B. M., & Holze, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035512 · Cited by 14 · see citing works
Wang, L., Tu, L., Zhang, J., Xu, K., & Qian, W. (2017) · BioMed Research International · doi:10.1155/2017/2540540 · Cited by 14 · see citing works
Self-citationLee, Y., Yi, H., Suh, Y., Byun, J.-S., Eun, H. S., Kim, S. Y., Seo, W., Jeong, J., Choi, W., Kim, M., et al. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.0218 · Cited by 12 · see citing works
Unlocking the post-transplant microenvironment for successful islet function and survival
Doherty, D. T., Khambalia, H., van Dellen, D., Jennings, R. E., & Hanley, K. P. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1250126 · Cited by 9 · see citing works
Ueta, H., Xu, X.-D., Yu, B., Kitazawa, Y., Yu, E., Hara, Y., Morita-Nakagawa, M., Shu, Z., Sawanobori, Y., Ueha, S., et al. (2020) · International Immunology · doi:10.1093/intimm/dxaa076 · Cited by 10 · see citing works
Cell Therapy as a Tool for Induction of Immunological Tolerance after Liver Transplantation
Kholodenko, I., Kholodenko, R., Lupatov, A., & Yarygin, K. N. (2018) · Bulletin of experimental biology and medicine · doi:10.1007/s10517-018-4213-8 · Cited by 8 · see citing works
PMA induces the differentiation of monocytes into immunosuppressive MDSCs
Wang, H., Ji, J., Zhuang, Y., Zhou, X., Zhao, Y. X., & Zhang, X. (2021) · Clinical & Experimental Immunology · doi:10.1111/cei.13657 · Cited by 9 · see citing works
Stellate Cells in Hepatic Immunological Tolerance
Gandhi, C. R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800134-9.00014-2 · Cited by 9 · see citing works
Zhou, C., Kong, D., Liu, J., Lu, Z., Guo, H., Wang, W., Qiu, J., Liu, X., & Wang, Y. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.05.002 · Cited by 6 · see citing works
Jiang, X., Zhu, L., Cui, Z.-M., Guo, D., Sun, W., Lin, L., Tang, Y.-F., Wang, X.-F., & Liang, J. (2010) · Transplant Immunology · doi:10.1016/j.trim.2010.10.005 · Cited by 6 · see citing works
Gandhi, C. R. (2010) · Molecular pathology library · doi:10.1007/978-1-4419-7107-4_5 · Cited by 5 · see citing works
Liao, H.-J., Cheng, L.-P., Hsieh, Y.-C., Wu, C.-S., Yang, H.-C., Chyuan, I.-T., & Hsu, P.-N. (2026) · Journal of Microbiology, Immunology and Infection · doi:10.1016/j.jmii.2025.07.001 · Cited by 4 · see citing works
Self-citationCan Combined Therapy Benefit Immune Checkpoint Blockade Response in Hepatocellular Carcinoma?
Fan, Z.-H., Sun, X.-D., Chen, Y.-G., & Lv, G.-Y. (2018) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520618666181114112431 · Cited by 3 · see citing works
Clinicopathological features of graft versus host disease‐associated myositis
Kazuta, T., Murakami, A., Noda, S., Hirano, S., Kito, H., Tsujikawa, K., Nakanishi, H., Kimura, S., Sahashi, K., Koike, H., et al. (2023) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51973 · Cited by 3 · see citing works
Triptolide promotes differentiation of human monocytes into immunosuppressive MDSCs
Wang, H., Yang, H., Zhang, X., & Zhou, X. (2024) · Cellular Immunology · doi:10.1016/j.cellimm.2024.104836 · Cited by 2 · see citing works
Self-citationMechanisms of Murine Spontaneous Liver Transplant Tolerance
Liu, H., Guan, L., Li, Z., Wang, Z., & Li, W. (2014) · Experimental and Clinical Transplantation · doi:10.6002/ect.2013.0154 · Cited by 2 · see citing works
Khadem, F. (2016) · Mspace (University of Manitoba)
Zigmond, E., & Shetty, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-51709-0_1
Bénichou, G., & Kawai, T. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-386456-7.02205-x
Mechanisms of Allograft Rejection and Tolerance/Immunosenescence
Moris, D., & Kirk, A. D. (2023) · Wiley eBooks · doi:10.1002/9781119633884.ch11
- Authors
- Yang, H., Chou, H., Gu, X., Wang, L., Brown, K. E., Fung, J. J., Lu, L., & Qian, S.
- Affiliations
- Cleveland Clinic (US)
- Cleveland Clinic Research (US)
- Corresponding author
- Qian, Shiguang
- Venue
- Hepatology
- Published
- 2009-12
- Volume
- 50
- Issue
- 6
- Pages
- 1981-1991
- ISSN
- 0270-9139 (ISSN-L)
- PMC
- PMC2896244
- OpenAlex
- W1985569603
- Cited by
- 71
- References
- 31
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 5 · 2015: 9 · 2014: 11 · 2013: 6 · 2012: 5
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK084192, R01DK058316, DK58316)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Keywords
- hepatic stellate cells, immunomodulation, islet allograft rejection, T cell apoptosis, regulatory T cells, Foxp3, interferon-gamma signaling, PD-L1, liver transplantation, immune privilege, T cell tolerance
- MeSH terms
- Interferon gamma Receptor, Animals, Interferon-gamma, Male, Membrane Glycoproteins, Mice, Inbred Strains, Peptides, Signal Transduction, Islets of Langerhans Transplantation, Apoptosis, Receptors, Interferon, B7-1 Antigen, CD8-Positive T-Lymphocytes, T-Lymphocytes, Regulatory, Mice, Forkhead Transcription Factors, Hepatic Stellate Cells, B7-H1 Antigen
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
