Human Hepatic Stellate Cells Inhibit T-Cell Response Through B7-H1 Pathway
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BACKGROUND: The liver is an immunologic privileged organ; liver allografts are accepted across major histocompatibility complex barriers in many species. However, hepatocyte transplants are acutely rejected, suggesting a role for liver nonparenchymal cells in regulating the immunoresponse. We have shown potent immunoregulatory activity of hepatic stellate cells (HSCs) in mice. The aim of this study was to examine the immunoregulatory activity of human HSCs. METHODS: HSCs were isolated from normal human livers for analyses of their impact on T-cell response. RESULTS: HSCs expressed low HLA-DR and costimulatory molecules CD40 and CD80 but constitutively expressed high levels of CD54. Interferon-γ stimulated HSCs to express B7-H1 in a dose-dependent manner and produce the suppressive cytokines interleukin-6, interleukin-10, and transforming growth factor-β but did not affect expression of HLA-DR, CD40, and CD80. Human HSCs did not stimulate allogeneic T-cell proliferative response, indicating that they are not professional antigen-presenting cells. HSCs markedly inhibited T-cell response elicited by either allogeneic antigen-presenting cells or CD3/CD28 beads, which was associated with increases in activated CD4 and CD8 T-cell apoptosis. Addition of anti-B7-H1 blocking antibody significantly reversed the inhibitory effect. CONCLUSIONS: Human HSCs demonstrate potent immunoregulatory activity via B7-H1-mediated induction of apoptosis in activated T cells. Understanding of the involved mechanisms may lead to development of novel therapeutic approaches for treatment of liver diseases.
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HSCs cull the pool of activated T cells by expressing PD-L1 to induce T cell apoptosis.
“HSCs cull the pool of activated T cells by expressing PD-L1 to induce T cell apoptosis (46–48)”
From Hepatic Stellate Cell-Immune Interactions in NASH (2022) · cites this paper as [48]
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Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., et al. (2002) · Nature Medicine · doi:10.1038/nm730 · Cited by 5,025 · see citing works
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
Friedman, S. L. (2008) · Physiological Reviews · doi:10.1152/physrev.00013.2007 · Cited by 2,842 · see citing works
Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708 · see citing works
Greenwald, R. J., Freeman, G. J., & Sharpe, A. H. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115611 · Cited by 2,318 · see citing works
The PD‐1 pathway in tolerance and autoimmunity
Francisco, L. M., Sage, P. T., & Sharpe, A. H. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00923.x · Cited by 2,300 · see citing works
Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege
Griffith, T. S., Brunner, T., Fletcher, S. M., Green, D. R., & Ferguson, T. A. (1995) · Science · doi:10.1126/science.270.5239.1189 · Cited by 1,990 · see citing works
Lethal effect of the anti-Fas antibody in mice
Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., & Nagata, S. (1993) · Nature · doi:10.1038/364806a0 · Cited by 1,881 · see citing works
Induction of Immunological Tolerance by Porcine Liver Allografts
Calne, R. Y., Sells, R. A., Peña, J., Davis, D., Millard, P. R., Herbertson, B. M., BINNS, R. M., & Davies, D. A. L. (1969) · Nature · doi:10.1038/223472a0 · Cited by 827 · see citing works
Murine liver allograft transplantation: Tolerance and donor cell chimerism
Sg, Q., Demetris, A. J., Murase, N., Rao, A. S., Fung, J. J., & Starzl, T. E. (1994) · Hepatology · doi:10.1002/hep.1840190418 · Cited by 451 · see citing works
Self-citationLumsden, A. B., Henderson, M. J., & Kutner, M. H. (1988) · Hepatology · doi:10.1002/hep.1840080207 · Cited by 427 · see citing works
Ito Cells Are Liver-Resident Antigen-Presenting Cells for Activating T Cell Responses
Winau, F., Hegasy, G., Weiskirchen, R., Weber, S., Cassan, C., Sieling, P. A., Modlin, R. L., Liblau, R. S., Gressner, A. M., & Kaufmann, S. H. E. (2007) · Immunity · doi:10.1016/j.immuni.2006.11.011 · Cited by 410 · see citing works
WEANING OF IMMUNOSUPPRESSION IN LIVER TRANSPLANT RECIPIENTS12
Mazariegos, G. V., Reyes, J. D., Marino, I. R., Demetris, A. J., Flynn, B., Irish, W. D., McMichael, J., Fung, J. J., & Starzl, T. E. (1997) · Transplantation · doi:10.1097/00007890-199701270-00012 · Cited by 410 · see citing works
Self-citationB7-H1 Determines Accumulation and Deletion of Intrahepatic CD8+ T Lymphocytes
Dong, H., Zhu, G., Tamada, K., Flies, D. B., van Deursen, J. M. A., & Chen, L. (2004) · Immunity · doi:10.1016/s1074-7613(04)00050-0 · Cited by 370 · see citing works
The liver as a site of T-cell apoptosis: graveyard, or killing field?
Crispe, I. N., Dao, T., Klugewitz, K., Mehal, W. Z., & Metz, D. P. (2000) · Immunological Reviews · doi:10.1034/j.1600-0528.2002.017412.x · Cited by 321 · see citing works
Qian, S., Lu, L., Fu, F., Li, Y., Li, W., Starzl, T. E., Fung, J. J., & Thomson, A. W. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.10.4654 · Cited by 301 · see citing works
Self-citationInhibition of T–Cell Responses by Hepatic Stellate Cells Via B7–H1-Mediated T–Cell Apoptosis in Mice
Yu, M., Chen, C., Liang, X., Wang, L., Gandhi, C. R., Fung, J. J., Lu, L., & Qian, S. (2004) · Hepatology · doi:10.1002/hep.20488 · Cited by 301 · see citing works
Self-citationLiver transplantation across ABO blood group barriers
Gugenheim, J., Samuel, D., Bismuth, H., & REYNES, M. (1990) · The Lancet · doi:10.1016/0140-6736(90)92082-s · Cited by 300 · see citing works
Diehl, L., Schurich, A., Grochtmann, R., Hegenbarth, S., Chen, L., & Knolle, P. A. (2008) · Hepatology · doi:10.1002/hep.21965 · Cited by 291 · see citing works
The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo
Huang, L., Soldevila, G., Leeker, M., Flavell, R. A., & Crispe, I. N. (1994) · Immunity · doi:10.1016/s1074-7613(94)80016-2 · Cited by 282 · see citing works
Selective Retention of Activated CD8+ T Cells by the Normal Liver
Mehal, W. Z., Juedes, A. E., & Crispe, I. N. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.6.3202 · Cited by 253 · see citing works
Defining the outcome of immunosuppression withdrawal after liver transplantation
Devlin, J., Doherty, D. G., Thomson, L., Wong, T., Donaldson, P. T., Portmann, B. C., & Williams, R. L. (1998) · Hepatology · doi:10.1002/hep.510270406 · Cited by 237 · see citing works
Weaning Of Immunosuppression In Long-Term Liver Transplant Recipients
Ramos, H. C., Reyes, J., Abu-Elmagd, K. M., Zeevi, A., Reinsmoen, N. L., Tzakis, A. G., Demetris, A. J., Fung, J. J., Flynn, B., McMichael, J., et al. (1995) · Transplantation · doi:10.1097/00007890-199501270-00010 · Cited by 236 · see citing works
Self-citationFifteen years of clinical liver transplantation
Starzl, T. E., Koep, L. J., Halgrimson, C. G., Hood, J., Schröter, G., Porter, K. A., & Weil, R. M. (1979) · Gastroenterology · doi:10.1016/0016-5085(79)90294-4 · Cited by 194 · see citing works
Kamada, N., BRONS, G., & DAVIES, H. F. S. (1980) · Transplantation · doi:10.1097/00007890-198005000-00021 · Cited by 178 · see citing works
Operational tolerance after liver transplantation
Orlando, G., Söker, S., & Wood, K. J. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.03.006 · Cited by 173 · see citing works
In Vivo Immune Modulatory Activity of Hepatic Stellate Cells in Mice
Chen, C.-H., Kuo, L.-M., Chang, Y., Wu, W., Goldbach, C., Ross, M. A., Stolz, D. B., Chen, L., Fung, J. J., Lu, L., et al. (2006) · Hepatology · doi:10.1002/hep.21379 · Cited by 154 · see citing works
Self-citationIsolation and Culture of Hepatic Stellate Cells
Weiskirchen, R., & Gressner, A. M. (2005) · Humana Press eBooks · doi:10.1385/1-59259-940-0:099 · Cited by 146 · see citing works
Bruno, R., Galastri, S., Sacchi, P., Cima, S., Caligiuri, A., DeFranco, R., Milani, S., Gessani, S., Fantuzzi, L., Liotta, F., et al. (2009) · Gut · doi:10.1136/gut.2008.163287 · Cited by 142 · see citing works
Hepatic Stellate Cells Function as Regulatory Bystanders
Ichikawa, S., Mucida, D., Tyznik, A. J., Kronenberg, M., & Cheroutre, H. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003917 · Cited by 141 · see citing works
Chou, H.-S., Hsieh, C., Yang, H.-R., Wang, L., Arakawa, Y., Brown, K., Wu, Q., Lin, F., Peters, M. G., Fung, J. J., et al. (2011) · Hepatology · doi:10.1002/hep.24162 · Cited by 126 · see citing works
Self-citationSPLIT TOLERANCE INDUCED BY ORTHOTOPIC LIVER TRANSPLANTATION IN MICE1
Dahmen, U., Qian, S., Rao, A. S., Demetris, A. J., Fu, F., Sun, H., Gao, L., Fung, J. J., & Starzl, T. E. (1994) · Transplantation · doi:10.1097/00007890-199407000-00001 · Cited by 119 · see citing works
Self-citationChou, H.-S., Hsieh, C., Charles, R., Wang, L., Wagner, T., Fung, J. J., Qian, S., & Lu, L. L. (2011) · Transplantation · doi:10.1097/tp.0b013e31823ffd39 · Cited by 105 · see citing works
Self-citationJiang, G., Yang, H.-R., Wang, L., Wildey, G. M., Fung, J., Qian, S., & Lu, L. (2008) · Transplantation · doi:10.1097/tp.0b013e31818bfd13 · Cited by 96 · see citing works
Self-citationNegative Regulation of T-Cell Function by PD-1
Zha, Y. Y., Blank, C., & Gajewski, T. F. (2004) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v24.i4.10 · Cited by 92 · see citing works
Successful liver transplantation from crossmatch-positive donors.
Iwatsuki, S., Iwaki, Y., Takahisa, K. A. N. O., Klintmalm, G. B. G., Koep, L. J., Weil, R., & Starzl, T. E. (1981) · PubMed · Cited by 92 · see citing works
The effect of portacaval shunt on delayed-hypersensitivity responses following antigen feeding
Callery, M. P., Kamei, T., & Flye, M. W. (1989) · Journal of Surgical Research · doi:10.1016/0022-4804(89)90208-4 · Cited by 90 · see citing works
Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism
Schildberg, F. A., Wojtalla, A., Siegmund, S. V., Endl, E., Diehl, L., Abdullah, Z., Kurts, C., & Knolle, P. A. (2011) · Hepatology · doi:10.1002/hep.24352 · Cited by 90 · see citing works
Ilan, Y., Sauter, B. V., Chowdhury, N. R., Reddy, B., Thummala, N. R., Droguett, G., Davidson, A., Ott, M., Horwitz, M. S., & Chowdhury, J. R. (1998) · Hepatology · doi:10.1002/hep.510270525 · Cited by 84 · see citing works
Dangi, A., Sumpter, T. L., Kimura, S., Stolz, D. B., Murase, N., Raimondi, G., Yoram Vodovotz, B., Huang, C., Thomson, A. W., & Gandhi, C. R. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102460 · Cited by 77 · see citing works
Yang, H., Chou, H., Gu, X., Wang, L., Brown, K. E., Fung, J. J., Lu, L., & Qian, S. (2009) · Hepatology · doi:10.1002/hep.23202 · Cited by 71 · see citing works
Self-citationYu, S., Nakafusa, Y., & Flye, M. W. (1994) · PubMed · Cited by 60 · see citing works
APOPTOSIS OF T LYMPHOCYTES IN LIVER AND/OR SMALL BOWEL ALLOGRAFTS DURING TOLERANCE INDUCTION1
Meyer, D., Baumgardt, S., Löffeler, S., Czub, S., Otto, C., Gassel, H. ‐., Timmermann, W., Thiede, A., & Ulrichs, K. F. A. (1998) · Transplantation · doi:10.1097/00007890-199812150-00018 · Cited by 43 · see citing works
Yang, H., Hsieh, C., Wang, L., Fung, J. J., Lü, L., & Qian, S. (2009) · Microsurgery · doi:10.1002/micr.20697 · Cited by 38 · see citing works
Self-citationProposed New Method for Separating Isotopes
Stangeby, P. C., & Allen, J. E. (1971) · Nature · doi:10.1038/233472a0 · Cited by 34 · see citing works
Qian, S., Thai, N., Lü, L., Fung, J. J., & Thomson, A. W. (1997) · Transplantation Reviews · doi:10.1016/s0955-470x(97)80015-8 · Cited by 29 · see citing works
Self-citationHepatic antigen-presenting cells and regulation of liver transplant outcome
Thomson, A. W., Geller, D. A., Gandhi, C. R., Murase, N., Demetris, A. J., & Beer–Stolz, D. (2011) · Immunologic Research · doi:10.1007/s12026-011-8223-0 · Cited by 18 · see citing works
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Immunology in the liver — from homeostasis to disease
Heymann, F., & Tacke, F. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.200 · Cited by 1,180 · see citing works
Tsilimigras, D. I., Brodt, P., Clavien, P., Muschel, R. J., D'Angelica, M. I., Endo, I., Parks, R. W., Doyle, M. B., de Santibáñes, E., & Pawlik, T. M. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00261-6 · Cited by 576 · see citing works
Immunity, tolerance and autoimmunity in the liver: A comprehensive review
Doherty, D. G. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.08.020 · Cited by 313 · see citing works
Immune tolerance in liver disease
Crispe, I. N. (2014) · Hepatology · doi:10.1002/hep.27254 · Cited by 277 · see citing works
Weiskirchen, R., & Tacke, F. (2014) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2304-3881.2014.11.03 · Cited by 269 · see citing works
Liver-Mediated Adaptive Immune Tolerance
Zheng, M., & Tian, Z. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02525 · Cited by 241 · see citing works
Fisicaro, P., Barili, V., Rossi, M., Montali, I., Vecchi, A. L., Acerbi, G., Laccabue, D., Zecca, A., Penna, A., Missale, G., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00849 · Cited by 165 · see citing works
Immunotoxicity from checkpoint inhibitor therapy: clinical features and underlying mechanisms
Fessas, P., Possamai, L. A., Clark, J., Daniels, E., Gudd, C. L. C., Mullish, B. H., Alexander, J. L., & Pinato, D. J. (2019) · Immunology · doi:10.1111/imm.13141 · Cited by 105 · see citing works
Hepatic Stellate Cells: Dictating Outcome in Nonalcoholic Fatty Liver Disease
Wiering, L., Subramanian, P., & Hammerich, L. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.02.010 · Cited by 80 · see citing works
Hepatic Stellate Cell-Immune Interactions in NASH
Carter, J. K., & Friedman, S. L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.867940 · Cited by 79 · see citing works
The Contribution of Non-Professional Antigen-Presenting Cells to Immunity and Tolerance in the Liver
Mehrfeld, C., Zenner, S., Kornek, M., & Kornek, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00635 · Cited by 78 · see citing works
Development of gene transfer for induction of antigen-specific tolerance
Sack, B. K., Herzog, R. W., Terhorst, C., & Markusic, D. M. (2014) · Molecular Therapy - Methods & Clinical Development · doi:10.1038/mtm.2014.13 · Cited by 70 · see citing works
Role of hepatic stellate cell (HSC)-derived cytokines in hepatic inflammation and immunity
Gupta, G., Khadem, F., & Uzonna, J. E. (2018) · Cytokine · doi:10.1016/j.cyto.2018.09.004 · Cited by 70 · see citing works
The unique immune microenvironment of liver metastases: Challenges and opportunities
Ciner, A., Jones, K. I., Muschel, R. J., & Brodt, P. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.06.003 · Cited by 66 · see citing works
Regulator Versus Effector Paradigm: Interleukin-10 as Indicator of the Switching Response
Mingomataj, E., & Bakiri, A. H. (2015) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8514-7 · Cited by 54 · see citing works
The Role of Diverse Liver Cells in Liver Transplantation Tolerance
Jiang, Y., Que, W., Zhu, P., & Li, X. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01203 · Cited by 53 · see citing works
Raicevic, G., Najar, M., Najimi, M., Taghdouini, A. E., van Grunsven, L. A., Sokal, E. M., & Toungouz, M. (2014) · Cytotherapy · doi:10.1016/j.jcyt.2014.10.001 · Cited by 51 · see citing works
Antifibrotic therapies for metabolic dysfunction-associated steatotic liver disease
Schwabe, R. F., Tacke, F., Sugimoto, A., & Friedman, S. L. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101421 · Cited by 50 · see citing works
Li, Y., Kim, B.-G., Qian, S., Letterio, J. J., Fung, J. J., Lu, L., & Lin, F. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500139 · Cited by 45 · see citing works
Self-citationImmune-metabolic interactions in homeostasis and the progression to NASH.
Hoogerland, J., Staels, B., & Dombrowicz, D. (2022) · Trends in endocrinology and metabolism · doi:10.1016/j.tem.2022.07.001 · Cited by 41 · see citing works
Mechanisms of liver-induced tolerance
Moris, D., Lü, L., & Qian, S. (2016) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000380 · Cited by 40 · see citing works
Self-citationZhang, G., Guanchang, J., Liwen, L., Huifen, W., Zhigang, R., Ranran, S., & Yu, Z. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.918869 · Cited by 39 · see citing works
Xu, Y., Huang, Y., Xu, W., Zheng, X., Yi, X., Huang, L., Wang, Y., & Wu, K. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s234920 · Cited by 37 · see citing works
The evidence-based multifaceted roles of hepatic stellate cells in liver diseases: A concise review
Kim, J., & Kim, Y. J. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122547 · Cited by 39 · see citing works
Immunotherapy for Hepatocellular Carcinoma: Current Limits and Prospects
Zhong, C. F., Li, Y., Yang, J., Jin, S., Chen, G., Li, D., Fan, X., & Lin, H. M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.589680 · Cited by 32 · see citing works
Molecular Mechanisms of Colorectal Liver Metastases
Tsilimigras, D. I., Ntanasis‐Stathopoulos, I., & Pawlik, T. M. (2023) · Cells · doi:10.3390/cells12121657 · Cited by 31 · see citing works
Hepatic immune tolerance induced by hepatic stellate cells
Hsieh, C. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i42.11887 · Cited by 28 · see citing works
Immunological aspects of liver cell transplantation
Oldhafer, F., Bock, M., Falk, C. S., & Vondran, F. W. R. (2016) · World Journal of Transplantation · doi:10.5500/wjt.v6.i1.42 · Cited by 27 · see citing works
Hepatic immune regulation by stromal cells
Schildberg, F. A., Sharpe, A. H., & Turley, S. J. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.10.002 · Cited by 25 · see citing works
Ali, E., Trailin, A. V., Ambrożkiewicz, F., Liška, V., & Hemminki, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315292 · Cited by 24 · see citing works
Sällberg, M., & Pasetto, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00552 · Cited by 22 · see citing works
Definition of the Chemical and Immunological Signals Involved in Drug-Induced Liver Injury
Ali, S.-E., Waddington, J. C., Park, B. K., & Meng, X. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00275 · Cited by 22 · see citing works
Cross-talk between hepatic stellate cells and T lymphocytes in liver fibrosis
Li, H., Ding, P., Peng, B., & Ming, Y. (2021) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2021.04.007 · Cited by 20 · see citing works
Tanimine, N., Ohira, M., Tahara, H., Ide, K., Tanaka, Y., Onoe, T., & Ohdan, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01615 · Cited by 18 · see citing works
The Tumor Microenvironment of Hepatocellular Carcinoma: Untying an Intricate Immunological Network
Volponi, C., Gazzillo, A., & Bonavita, E. (2022) · Cancers · doi:10.3390/cancers14246151 · Cited by 19 · see citing works
Wang, Y., Tian, Y., Ding, Y., Wang, J., Yan, S., Zhou, L., Xie, H., Chen, H., Li, H., Zhang, J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105096 · Cited by 19 · see citing works
The CD8 T‐cell response during tolerance induction in liver transplantation
Wong, Y. C., McCaughan, G. W., Bowen, D. G., & Bertolino, P. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.53 · Cited by 19 · see citing works
The T Cell Receptor Immune Repertoire Protects the Liver From Reconsitution
Liang, Q. D., Hu, Y., Zhang, M., Lin, C., Zhang, W., Li, Y., Zhu, P., Xue, P., Chen, Y., Li, Q., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.584979 · Cited by 17 · see citing works
Jiang, Z., Shen, Q., Chen, H., Yang, Z., Shuai, M., & Zheng, S. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000491955 · Cited by 17 · see citing works
Oran, D. C., Lokumcu, T., Inceoglu, Y., Akolpoglu, M. B., Albayrak, Ö., Bal, T., Kurtoğlu, M., Erkan, M., Can, F., Onder, T. B., et al. (2019) · Materials Today Bio · doi:10.1016/j.mtbio.2019.100006 · Cited by 15 · see citing works
Incidence of acute rejection and patient survival in combined heart–liver transplantation
Zhao, K., Wang, R. X., Kamoun, M., Callans, L. E., Bremner, R., Rame, J. E., McLean, R. C., Cevasco, M., Olthoff, K. M., Levine, M. H., et al. (2022) · Liver Transplantation · doi:10.1002/lt.26448 · Cited by 14 · see citing works
Immune Checkpoints and the Immunology of Liver Fibrosis
Tsomidis, I., Voumvouraki, A., & Kouroumalis, E. (2025) · Livers · doi:10.3390/livers5010005 · Cited by 14 · see citing works
Cellular prognostic markers in hepatocellular carcinoma
Buonaguro, L., Tagliamonte, M., Petrizzo, A., Damiano, E., Tornesello, M. L., & Buonaguro, F. M. (2015) · Future Oncology · doi:10.2217/fon.15.39 · Cited by 14 · see citing works
Zhang, H., He, G., Kong, Y., Chen, Y., Wang, B., Sun, X., Jia, B., Xie, X., Wang, X., Chen, D., et al. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12917 · Cited by 13 · see citing works
Wang, L., Huang, Y., Chen, J., Gao, J., Chen, S., Zhao, M., Lin, J., Zhou, S., Shen, Y., & Cheng, Y. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1635763 · Cited by 14 · see citing works
Self-citationHepatic Stellate Cells Functional Heterogeneity in Liver Cancer
Sererols-Viñas, L., Garcia‐Vicién, G., Ruiz-Blázquez, P., Lee, T., Lee, Y. A., Gonzalez‐Sanchez, E., Vaquero, J., Moles, A., Filliol, A. A., & Affò, S. (2025) · Seminars in Liver Disease · doi:10.1055/a-2551-0724 · Cited by 12 · see citing works
Zhang, M., Jing, Y., Xu, W., Shi, X., Zhang, W., Chen, P., Cao, X., Han, X., Duan, X., & Ren, J. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06324-8 · Cited by 10 · see citing works
Locoregional therapies combined with immune checkpoint inhibitors for liver metastases
Zhang, X., Zhou, Y., Wei, G.-X., Luo, Y., & Qiu, M. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03484-1 · Cited by 11 · see citing works
Yang, A.-R., Zhou, M., Gao, Y.-X., & Zhang, Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114843 · Cited by 12 · see citing works
BIOMARKERS OF IMMUNE TOLERANCE IN LIVER TRANSPLANTATION
Shevchenko, O. P., Kurabekova, R. M., & Tsirulniкova, O. M. (2016) · Russian Journal of Transplantology and Artificial Organs · doi:10.15825/1995-1191-2016-3-137-144 · Cited by 6 · see citing works
Zhou, C., Kong, D., Liu, J., Lu, Z., Guo, H., Wang, W., Qiu, J., Liu, X., & Wang, Y. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.05.002 · Cited by 6 · see citing works
Hepatic Stellate Cells and Hepatocytes as Liver Antigen-Presenting Cells during B. abortus Infection
Benitez, P. C. A., Viglietti, A. I. P., Elizalde, M., Giambartolomei, G. H., Quarleri, J., & Delpino, M. (2020) · Pathogens · doi:10.3390/pathogens9070527 · Cited by 5 · see citing works
Intrahepatic regulation of antiviral T cell responses at initial stages of viral infection
Liang, Y., Kwota, Z., & Sun, J. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.07.021 · Cited by 4 · see citing works
Kurabekova, R. M., Shevchenko, O. P., Tsirulniкova, O. M., Можейко, Н. П., Tsiroulnikova, I. E., Monakhov, A. R., & Gautier, S. V. (2016) · Russian Journal of Transplantology and Artificial Organs · doi:10.15825/1995-1191-2016-3-16-21 · Cited by 3 · see citing works
Transcriptomics of a cytoglobin knockout mouse: Insights from hepatic stellate cells and brain
Porto, E., Backer, J. D., Thủy, L. T. T., Kawada, N., & Hankeln, T. (2023) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2023.112405 · Cited by 2 · see citing works
TRANSFORMING GROWTH FACTOR 1 AT LIVER TRANSPLANTATION
Kurabekova, R. M., Shevchenko, O. P., & Tsirulniкova, O. M. (2015) · Russian Journal of Transplantology and Artificial Organs · doi:10.15825/1995-1191-2015-3-76-82 · Cited by 2 · see citing works
TRANSFORMING GROWTH FACTOR 1 IN CHILDREN OF EARLY AGE WITH LIVER TRANSPLANTATION
Kurabekova, R. M., Shevchenko, O. P., Tsirulniкova, O. M., Tsiroulnikova, I. E., Олефиренко, Г. А., & Gautier, S. V. (2015) · Russian Journal of Transplantology and Artificial Organs · doi:10.15825/1995-1191-2014-4-27-32 · Cited by 1 · see citing works
Siegel, P. M., Nyström, H., & Brodt, P. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91706-3.00011-4 · Cited by 1 · see citing works
Autoimmune Hepatitis and Overlap Syndromes
Janmohamed, A., & Hirschfield, G. M. (2018) · doi:10.1002/9781119237662.ch19 · Cited by 1 · see citing works
Experimental models with specific approaches to augment human fetal liver cell engraftment
Patil, P. B. (2014) · Gothenburg University Publications Electronic Archive (Gothenburg University) · doi:10.13140/2.1.1357.9840
Katz, S. C., Bamboat, Z. M., Pillarisetty, V. G., & DeMatteo, R. P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-34062-5.00010-8
Wang, D., Xiong, L., Wang, Y., Weng, J., & Gao, L. (2020) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2020.06.012
RetractedZigmond, E., & Shetty, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-51709-0_1
Regulatory T Cells in the Mosaic of Liver Transplantation Tolerance
Terzieva, V. I., Uzunova, Y., Gornev, R., & Spassov, L. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.94362
Liver Stereotactic Body Radiotherapy (SBRT)
Leaman-Alcibar, O., López‐Campos, F., Blanco, J. A., Pomata, P. T., & Rubio, C. (2022) · Interdisciplinary cancer research · doi:10.1007/16833_2022_94
Gautier, S. V., Shevchenko, O. P., Tsirulniкova, O. M., Kurabekova, R. M., & Pashkova, I. E. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.108301
Mechanisms of Allograft Rejection and Tolerance/Immunosenescence
Moris, D., & Kirk, A. D. (2023) · Wiley eBooks · doi:10.1002/9781119633884.ch11
Sinusoidal cells and liver immunology
Szafranska, K., Sørensen, K. K., Lalor, P. F., & McCourt, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95262-0.00003-6
Zhang, Y.-F., Gan, W., Wang, W.-Q., & Liu, L. (2025) · Cancer and Metastasis Reviews · doi:10.1007/s10555-025-10295-x
IL - 17 et réponse inflammatoire systémique : focus sur le foie et le muscle
Beringer, A. (2018) · theses.fr (ABES) · doi:10.70675/2d9a348ez5879z4d92z938fz1e4047d398bc
Autoimmune Hepatitis and Overlap Syndromes
Ergenç, İ., & Heneghan, M. A. (2026) · doi:10.1002/9781394360031.ch22
- Authors
- Charles, R., Chou, H.-S., Wang, L., Fung, J. J., Lu, L., & Qian, S.
- Affiliations
- Cleveland Clinic (US)
- Corresponding author
- Qian, Shiguang
- Venue
- Transplantation
- Published
- 2013-07-15
- Volume
- 96
- Issue
- 1
- Pages
- 17-24
- ISSN
- 0041-1337 (ISSN-L)
- PMC
- PMC3696433
- OpenAlex
- W2008640671
- Cited by
- 72
- References
- 42
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 3 · 2023: 6 · 2022: 8 · 2021: 4 · 2020: 10 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 8 · 2015: 7 · 2014: 7
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R21AI090468, AI090468)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK084192, R01DK058316, DK084192)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- hepatic stellate cells, PD-L1, T cell suppression, immune regulation, T cell apoptosis, interferon-gamma, IL-10, interleukin-6, TGF-beta, ICAM-1, CD40, CD80, HLA-DR, liver transplantation, hepatocyte transplantation, liver allograft rejection, costimulatory molecules
- MeSH terms
- Antibodies, Monoclonal, Cell Communication, Cells, Cultured, Graft Rejection, Humans, Immune Tolerance, Liver, T-Lymphocytes, Transplantation, Homologous, Signal Transduction, Liver Transplantation, Immunophenotyping, Apoptosis, B7-1 Antigen, Intercellular Adhesion Molecule-1, CD40 Antigens, Hepatic Stellate Cells, B7-H1 Antigen
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