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Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy
Open accessAbstract
Altered gut microbiome is associated with systemic inflammation and cirrhosis decompensation. However, the correlation of the oral microbiome with inflammation in cirrhosis is unclear. Our aim was to evaluate the oral microbiome in cirrhosis and compare with stool microbiome. Outpatients with cirrhosis (with/without hepatic encephalopathy [HE]) and controls underwent stool/saliva microbiome analysis (for composition and function) and also systemic inflammatory evaluation. Ninety‐day liver‐related hospitalizations were recorded. Salivary inflammation was studied using T helper 1 cytokines/secretory immunoglobulin A (IgA), histatins and lysozyme in a subsequent group. A total of 102 patients with cirrhosis (43 previous HE) and 32 age‐matched controls were included. On principal component analysis (PCA), stool and saliva microbiome clustered far apart, showing differences between sites as a whole. In salivary microbiome, with previous HE, relative abundance of autochthonous families decreased whereas potentially pathogenic ones (Enterobacteriaceae, Enterococcaceae) increased in saliva. Endotoxin‐related predicted functions were significantly higher in cirrhotic saliva. In stool microbiome, relative autochthonous taxa abundance reduced in previous HE, along with increased Enterobacteriaceae and Enterococcaceae. Cirrhotic stool microbiota demonstrated a significantly higher correlation with systemic inflammation, compared to saliva microbiota, on correlation networks. Thirty‐eight patients were hospitalized within 90 days. Their salivary dysbiosis was significantly worse and predicted this outcome independent of cirrhosis severity. Salivary inflammation was studied in an additional 86 age‐matched subjects (43 controls/43 patients with cirrhosis); significantly higher interleukin (IL)−6/IL‐1β, secretory IgA, and lower lysozyme, and histatins 1 and 5 were found in patients with cirrhosis, compared to controls. Conclusions: Dysbiosis, represented by reduction in autochthonous bacteria, is present in both saliva and stool in patients with cirrhosis, compared to controls. Patients with cirrhosis have impaired salivary defenses and worse inflammation. Salivary dysbiosis was greater in patients with cirrhosis who developed 90‐day hospitalizations. These findings could represent a global mucosal‐immune interface change in cirrhosis. (H epatology 2015;62:1260‐1271)
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“Recent studies have demonstrated differences in the duodenal and salivary microbiota between healthy controls and patients with cirrhosis86,88, suggesting that there are also qualitative and quantitative changes in the upper gastrointestinal tract that might be linked to changes in the more distal microbiota and contribute to the pathophysiology of CLD as well as the development of HCC.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [88]
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Cites
Cytoscape: A software Environment for integrated models of biomolecular interaction networks
Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003) · Genome Research · doi:10.1101/gr.1239303 · Cited by 51,888
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Langille, M. G. I., Zaneveld, J., Caporaso, J. G., McDonald, D., Knights, D., Reyes, J. A., Clemente, J. C., Burkepile, D. E., Vega Thurber, R. L., Knight, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2676 · Cited by 9,116
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820
Alterations of the human gut microbiome in liver cirrhosis
Qin, N., Yang, F., Li, A., Prifti, E., Chen, Y., Shao, L., Guo, J., Le Chatelier, E., Yao, J., Wu, L., et al. (2014) · Nature · doi:10.1038/nature13568 · Cited by 2,177
Statistical Methods for Detecting Differentially Abundant Features in Clinical Metagenomic Samples
White, J. R., Nagarajan, N., & Pop, M. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000352 · Cited by 1,599
Interaction between Phenolics and Gut Microbiota: Role in Human Health
Selma, M. V., Espín, J. C., & Tomás-Barberán, F. A. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902107d · Cited by 1,324
Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut
Mantis, N. J., Rol, N., & Corthésy, B. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.41 · Cited by 1,283
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Wijnant, K., Meulebroek, L. V., Pomian, B., Windt, K. D., Henauw, S. D., Michels, N., & Vanhaecke, L. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b05598 · Cited by 42
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Zeybel, M., Altay, Ö., Arif, M., Li, X., Yang, H., Fredolini, C., Akyıldız, M., Sağlam, B., Gönenli, M. G., Ural, D., et al. (2021) · Molecular Systems Biology · doi:10.15252/msb.202110459 · Cited by 43
Alterations in the gut microbiota and the efficacy of adjuvant probiotic therapy in liver cirrhosis
Wu, Z., Zhou, H., Liu, D., & Deng, F. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1218552 · Cited by 43
Alterations of the salivary and fecal microbiome in patients with primary sclerosing cholangitis
Lapidot, Y., Amir, A., Ben-Simon, S., Veitsman, E., Cohen‐Ezra, O., Davidov, Y., Weiss, P., Bradichevski, T., Segev, S., Koren, O., et al. (2020) · Hepatology International · doi:10.1007/s12072-020-10089-z · Cited by 42
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Sharma, S. P., Gupta, H., Kwon, G.-H., Lee, S., Song, S. H., Kim, J. S., Park, J. H., Kim, M. J., Yang, D., Park, H., et al. (2024) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2024.0349 · Cited by 42
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Human microbiome is a diagnostic biomarker in hepatocellular carcinoma
Rao, B., Lou, J., Wang, W., Li, A., Cui, G., Yu, Z., & Ren, Z. (2020) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2020.01.003 · Cited by 35
Can metagenomics unravel the impact of oral bacteriome in human diseases?
Chattopadhyay, I., Lu, W., Manikam, R., Malarvili, M. B., Ambati, R. R., & Gundamaraju, R. (2022) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2022.2102877 · Cited by 37
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Gui, Q., Jin, H., Zhu, F., Lu, H., Zhang, Q., Xu, J. M., Yang, Y., & Xiao, C. (2021) · Infectious Diseases of Poverty · doi:10.1186/s40249-021-00821-8 · Cited by 28
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Yue, B., Gao, Y., Hu, Y., Zhan, M., Wu, Y., & Lu, L. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1731 · Cited by 26
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Self-citationOmori, M., Kato‐Kogoe, N., Sakaguchi, S., Fukui, N., Yamamoto, K., Nakajima, Y., Inoue, K., Nakano, H., Motooka, D., Nakano, T., et al. (2020) · Clinical Oral Investigations · doi:10.1007/s00784-020-03592-y · Cited by 28
Zhang, J., Wang, W., Cui, X., Zhu, P.-L., Li, S., Yuan, S., Peng, D., & Peng, C. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117656 · Cited by 26
Stadlbauer, V., Komarova, I., Klymiuk, I., Durdević, M., Reisinger, A. C., Blesl, A., Rainer, F., & Horvath, A. (2020) · Liver International · doi:10.1111/liv.14382 · Cited by 27
Sookoian, S. C., & Pirola, C. J. (2021) · HepatoBiliary Surgery and Nutrition · doi:10.21037/hbsn-20-270 · Cited by 24
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Gairing, S. J., Schleicher, E. M., Galle, P. R., & Labenz, C. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000096 · Cited by 26
Lin, B., Ma, Y., Wu, S., Liu, Y., Liu, L., & Wu, L. (2019) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2019.0035 · Cited by 24
Raj, A. S., Shanahan, E. R., Tran, C. D., Bhat, P., Fletcher, L. M., Vesey, D. A., Morrison, M., Holtmann, G., & Macdonald, G. A. (2019) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000068 · Cited by 25
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Self-citationGilany, K., Mohamadkhani, A., Chashmniam, S., Shahnazari, P., Amini, M., Arjmand, B., Malekzadeh, R., & Gh, B. F. N. M. (2019) · PubMed Central · doi:10.22038/ijbms.2019.36669.8733 · Cited by 23
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Koch, M. (2016) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000699 · Cited by 23
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Zhou, Y., Vatsalya, V., Gobejishvili, L., Lamont, R. J., McClain, C. J., & Feng, W. (2018) · Hepatology Communications · doi:10.1002/hep4.1296 · Cited by 23
Chen, Y., Guo, K. M., Nagy, T., & Guo, T. L. (2019) · Food & Function · doi:10.1039/c9fo01740b · Cited by 22
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Wei, X., Jiang, S., Zhao, X., Li, H., Lin, W., Li, B., Lü, J., Sun, Y., & Yuan, J. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01856 · Cited by 21
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Chen, H., Yang, C., Yan, S., Liu, X., Zhou, L., & Yuan, X. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112571 · Cited by 24
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Bajaj, J. S., Fagan, A., Gavis, E. A., Mousel, T., Gallagher, M. L., Puri, P., Fuchs, M. A., Davis, B., Hylemon, P. B., Zhou, H., et al. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000384 · Cited by 20
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Self-citationOlianas, A., Guadalupi, G., Cabras, T., Contini, C., Serrao, S., Iavarone, F., Castagnola, M., Messana, I., Onali, S., Chessa, L., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24020959 · Cited by 18
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Bajaj, J. S., Fan, S., Thacker, L. R., Fagan, A., Gavis, E. A., White, M. B., Heuman, D. M., Fuchs, M. A., & Fiehn, O. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223061 · Cited by 18
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Vesković, M. N., Pejović, M., Šutulović, N., Hrnčić, D., Rašić-Marković, A., Stanojlović, O. P., & Mladenović, D. R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137405 · Cited by 19
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Nakagome, S., Chinen, H., Iraha, A., Hokama, A., Takeyama, Y., Sakisaka, S., Matsui, T., Kidd, J. R., Kídd, K. K., Said, H. S., et al. (2017) · Human Genetics · doi:10.1007/s00439-017-1764-0 · Cited by 15
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Metadata
- Authors
- Bajaj, J. S., Betrapally, N. S., Hylemon, P. B., Heuman, D. M., Daita, K., White, M. B., Unser, A., Thacker, L. R., Sanyal, A. J., Kang, D. J., Sikaroodi, M., & Gillevet, P. M.
- Affiliations
- Virginia Commonwealth University (US)
- George Mason University (US)
- Corresponding author
- Bajaj, Jasmohan S.
- ORCID
- Venue
- Hepatology
- Published
- 2015-05-06
- Volume
- 62
- Issue
- 4
- Pages
- 1260-1271
- ISSN
- 0270-9139 (ISSN-L)
- 1527-3350
- PMC
- PMC4587995
- OpenAlex
- W1518286619
- Cited by
- 325
- References
- 43
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 28 · 2023: 38 · 2022: 22 · 2021: 50 · 2020: 35 · 2019: 34 · 2018: 33 · 2017: 21 · 2016: 16 · 2015: 14
- FWCI
- 12.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 CX001076)
- National Institute on Alcohol Abuse and Alcoholism (R01AA020203, RO1AA020203)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK087913)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- liver cirrhosis, hepatic encephalopathy, salivary microbiota, gut microbiota, dysbiosis, systemic inflammation, Enterobacteriaceae, Enterococcaceae, endotoxin, secretory IgA, histatins, lysozyme, interleukin-6, IL-1β, mucosal immunity, hepatic decompensation
- MeSH terms
- Gastrointestinal Microbiome, Feces, Female, Hepatic Encephalopathy, Humans, Inflammation, Intestines, Liver Cirrhosis, Male, Middle Aged, Saliva, Microbiota, Dysbiosis
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