The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N 6‐methyladenosine‐dependent primary MicroRNA processing
Abstract
N 6‐Methyladenosine (m 6 A) modification has been implicated in many biological processes. However, its role in cancer has not been well studied. Here, we demonstrate that m 6 A modifications are decreased in hepatocellular carcinoma, especially in metastatic hepatocellular carcinoma, and that methyltransferase‐like 14 (METTL14) is the main factor involved in aberrant m 6 A modification. Moreover, METTL14 down‐regulation acts as an adverse prognosis factor for recurrence‐free survival of hepatocellular carcinoma and is significantly associated with tumor metastasis in vitro and in vivo. We confirm that METTL14 interacts with the microprocessor protein DGCR8 and positively modulates the primary microRNA 126 process in an m 6 A‐dependent manner. Further experiments show that microRNA 126 inhibits the repressing effect of METTL14 in tumor metastasis. Conclusion: These studies reveal an important role of METTL14 in tumor metastasis and provide a fresh view on m 6 A modification in tumor progression. (H epatology 2017;65:529‐543).
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N6-methyladenosine-dependent regulation of messenger RNA stability
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Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.687 · Cited by 4,106
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
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N6-methyladenosine Modulates Messenger RNA Translation Efficiency
Wang, X., Zhao, B. S., Roundtree, I. A., Lu, Z., Han, D., Ma, H., Weng, X., Chen, K., Shi, H., & He, C. (2015) · Cell · doi:10.1016/j.cell.2015.05.014 · Cited by 3,483
HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events
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Cited by
Role of RNA modifications in cancer
Barbieri, I., & Kouzarides, T. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-020-0253-2 · Cited by 1,312
Yang, X., Zhang, S., He, C., Xue, P., Zhang, L., He, Z., Zang, L., Feng, B., Sun, J., & Zheng, M. (2020) · Molecular Cancer · doi:10.1186/s12943-020-1146-4 · Cited by 513
RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
Yin, H., Zhang, X., Yang, P., Zhang, X., Peng, Y., Li, D., Yu, Y., Wu, Y., Wang, Y., Zhang, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21514-8 · Cited by 404
RNA modifications regulating cell fate in cancer
Delaunay, S., & Frye, M. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0319-0 · Cited by 365
Multiple functions of m6A RNA methylation in cancer
Pan, Y., Ma, P., Liu, Y., Li, W., & Shu, Y. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0590-8 · Cited by 312
Metadata
- Authors
- Ma, J., Yang, F., Zhou, C., Liu, F., Yuan, J., Wang, F., Wang, T., Xu, Q., Zhou, W., & Sun, S.
- Venue
- Hepatology
- Published
- 2016-12-24
- Volume
- 65
- Issue
- 2
- Pages
- 529-543
- ISSN
- 0270-9139 (ISSN-L)
- 1527-3350
- OpenAlex
- W2533922074
- Cited by
- 912
- References
- 6
- FWCI
- 14.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ma, J., Yang, F., Zhou, C., Liu, F., Yuan, J., Wang, F., Wang, T., Xu, Q., Zhou, W., & Sun, S. (2017). METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N 6‐methyladenosine‐dependent primary MicroRNA processing. Hepatology. https://doi.org/10.1002/hep.28885
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