The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST
Open accessAbstract
Background: N6-methyladenosine (m6A) is the most prevalent RNA epigenetic regulation in eukaryotic cells. However, understanding of m6A in colorectal cancer (CRC) is very limited. We designed this study to investigate the role of m6A in CRC. Methods: Expression level of METTL14 was extracted from public database and tissue array to investigate the clinical relevance of METTL14 in CRC. Next, gain/loss of function experiment was used to define the role of METTL14 in the progression of CRC. Moreover, transcriptomic sequencing (RNA-seq) was applied to screen the potential targets of METTL14. The specific binding between METTL14 and presumed target was verified by RNA pull-down and RNA immunoprecipitation (RIP) assay. Furthermore, rescue experiment and methylated RNA immunoprecipitation (Me-RIP) were performed to uncover the mechanism. Results: Clinically, loss of METTL14 correlated with unfavorable prognosis of CRC patients. Functionally, knockdown of METTL14 drastically enhanced proliferative and invasive ability of CRC cells in vitro and promoted tumorigenicity and metastasis in vivo. Mechanically, RNA-seq and Me-RIP identified lncRNA XIST as the downstream target of METTL14. Knockdown of METTL14 substantially abolished m6A level of XIST and augmented XIST expression. Moreover, we found that m6A-methylated XIST was recognized by YTHDF2, a m6A reader protein, to mediate the degradation of XIST. Consistently, XIST expression negatively correlated with METTL14 and YTHDF2 in CRC tissues. Conclusion: Our findings highlight the function and prognostic value of METTL14 in CRC and extend the understanding of the importance of RNA epigenetics in cancer biology.
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Self-citationTopology of the human and mouse m6A RNA methylomes revealed by m6A-seq
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N6-methyladenosine-dependent regulation of messenger RNA stability
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Self-citationALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
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Self-citationN6-methyladenosine Modulates Messenger RNA Translation Efficiency
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Self-citationA METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
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Self-citationDNA methylation landscapes: Provocative insights from epigenomics
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Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
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Self-citationNuclear m6A Reader YTHDC1 Regulates mRNA Splicing
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Colorectal liver metastasis: molecular mechanism and interventional therapy
Zhou, H., Liu, Z., Wang, Y., Wen, X., Amador, E. H., Yuan, L., Ran, X., Xiong, L., Ran, Y., Chen, W., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00922-2 · Cited by 298
Biological Function of Long Non-coding RNA (LncRNA) Xist
Wang, W., Min, L., Qiu, X., Wu, X., Liu, C., Ma, J., Zhang, D., & Zhu, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645647 · Cited by 248
Ye, M., Chen, J., Lu, F., Zhao, M., Wu, S., Hu, C., Yu, P., Kan, J., Bai, J., Tian, Y., et al. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01100-9 · Cited by 64
Reading the m6A-encoded epitranscriptomic information in development and diseases
Chen, Y., Zhou, Z., Chen, Y., & Chen, D. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01293-7 · Cited by 24
Metadata
- Authors
- Yang, X., Zhang, S., He, C., Xue, P., Zhang, L., He, Z., Zang, L., Feng, B., Sun, J., & Zheng, M.
- Venue
- Molecular Cancer
- Published
- 2020-02-28
- Volume
- 19
- Issue
- 1
- Pages
- 46-46
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W3010006672
- Cited by
- 513
- References
- 44
- FWCI
- 24.48
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yang, X., Zhang, S., He, C., Xue, P., Zhang, L., He, Z., Zang, L., Feng, B., Sun, J., & Zheng, M. (2020). METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST. Molecular Cancer. https://doi.org/10.1186/s12943-020-1146-4
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