Periportal SRY (Sex Determining Region Y)‐Box 9‐Positive Hepatocytes: Progenitors With a Biliary Leaning
Abstract
Alison, Malcolm R. Ph.D., D.Sc., F.R.C.Path.; Lin, Wey‐Ran M.D., Ph.D.Editor(s): Corey, Kathleen E.3; Malhi, Harmeet4 Author Information
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General hepatocyte-specific eRegulons were found for CEBPA, HNF1A, HNF4A, ONECUT1, FOXA1 and NFIB, and zonation-associated eRegulons such as ESR1 and SOX9 periportally and PPARG and AR pericentrally.
“We found general hepatocyte-specific eRegulons for CEBPA, HNF1A, HNF4A, ONECUT1, FOXA1 and NFIB21–23, and zonation-associated eRegulons such as ESR1 and SOX9 periportally24,25 and PPARG and AR pericentrally26,27.”
From Single-cell spatial multi-omics and deep learning dissect enhancer-driven gene regulatory networks in liver zonation (2024) · cites this paper as [25]
Cites
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Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration
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Bravo González-Blas, C., Matetovici, I., Hillen, H., Taskiran, I. I., Vandepoel, R., Christiaens, V., Sansores-García, L., Verboven, E., Hulselmans, G., Poovathingal, S., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-023-01316-4 · Cited by 85 · see citing works
“We found general hepatocyte-specific eRegulons for CEBPA, HNF1A, HNF4A, ONECUT1, FOXA1 and NFIB 21–23 , and zonation-associated eRegulons such as ESR1 and SOX9 peripor-tally 24,25 and PPARG and AR pericentrally 26,27 .”
Ductular Reactions in Liver Injury, Regeneration, and Disease Progression—An Overview
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Harnessing orthogonal recombinases to decipher cell fate with enhanced precision
Weng, W., Liu, X., Lui, K. O., & Zhou, B. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.09.007 · Cited by 26 · see citing works
Diverse functions of SOX9 in liver development and homeostasis and hepatobiliary diseases
Shang, T., Jiang, T., Cui, X., Pan, Y., Feng, X., Dong, L., & Wang, H. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.03.035 · Cited by 13 · see citing works
Enhancer grammar of liver cell types and hepatocyte zonation states
González-Blas, C. B., Matetovici, I., Hillen, H., Taskiran, I. I., Vandepoel, R., Christiaens, V., Sansores-García, L., Verboven, E., Hulselmans, G., Poovathingal, S., et al. (2022) · doi:10.1101/2022.12.08.519575 · Cited by 5 · see citing works
- Authors
- Alison, M. R., & Lin, W.
- Affiliations
- Barts Cancer Institute (GB)
- Linkou Chang Gung Memorial Hospital (TW)
- Venue
- Hepatology
- Published
- 2019-05-25
- Volume
- 70
- Issue
- 4
- Pages
- 1470-1473
- ISSN
- 0270-9139 (ISSN-L)
- 1527-3350
- OpenAlex
- W2942606873
- Cited by
- 5
- References
- 9
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- SOX9, periportal hepatocytes, biliary differentiation, liver regeneration, hepatocyte heterogeneity
- MeSH terms
- Animals, Cells, Cultured, Hepatectomy, Humans, Liver, Liver Regeneration, Portal System, Hepatocytes, Mice, SOX9 Transcription Factor
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