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Cited by 89Liver physiology and pathologyNerve injury and regenerationLiver Disease and Transplantation

Hepatic Nervous System in Development, Regeneration, and Disease

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Miller, Bess M., Oderberg, Isaac M., Goessling, Wolfram·2021·Hepatology
DOI 10.1002/hep.32055PMC PMC8639644
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Abstract

The liver is innervated by autonomic and sensory fibers of the sympathetic and parasympathetic nervous systems that regulate liver function, regeneration, and disease. Although the importance of the hepatic nervous system in maintaining and restoring liver homeostasis is increasingly appreciated, much remains unknown about the specific mechanisms by which hepatic nerves both influence and are influenced by liver diseases. While recent work has begun to illuminate the developmental mechanisms underlying recruitment of nerves to the liver, evolutionary differences contributing to species‐specific patterns of hepatic innervation remain elusive. In this review, we summarize current knowledge on the development of the hepatic nervous system and its role in liver regeneration and disease. We also highlight areas in which further investigation would greatly enhance our understanding of the evolution and function of liver innervation.

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  • Branch vagotomy exerts an inhibitory effect on liver regeneration following PH, particularly during early phases.

    “The literature suggests that branch vagotomy exerts an inhibitory effect on liver regeneration following PH, particularly during the early phases of the regenerative process.[ 7 ]”

    From Electroacupuncture Promotes Liver Regeneration by Activating DMV Acetylcholinergic Neurons-Vagus-Macrophage Axis in 70% Partial Hepatectomy of Mice (2024) · cites this paper as [7]

    The Partial hepatectomy section reports that hepatic vagotomy reduces hepatocyte proliferation and liver-to-body weight ratios seven days after partial hepatectomy. It does not establish that the inhibitory effect is particularly strong during early regeneration; its separate reference to early stages concerns sympathetic nervous system activity, not vagotomy. Page number is unavailable in our copy. (LLM, conf=0.86)

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Authors
Miller, B. M., Oderberg, I. M., & Goessling, W.
Affiliations
  • Brigham and Women's Hospital (US)
  • Broad Institute (US)
Corresponding author
Goessling, Wolfram
ORCID
Venue
Hepatology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2021-08-15
Volume
74
Issue
6
Pages
3513-3522
ISSN
  • 0270-9139 (ISSN-L)
  • 1527-3350
DOI
10.1002/hep.32055
PMC
PMC8639644
OpenAlex
W3177655839
Cited by
89
References
4
Citations by year
2026: 30 · 2025: 22 · 2024: 14 · 2023: 14 · 2022: 9
FWCI
1.21
Type
journal article
Language
en
Open access
Licence
Locations
  • Hepatology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (R24OD017870, R24OD035402)
  • National Institute on Alcohol Abuse and Alcoholism (F32AA027135, NIAAA F32AA027135‐01A1)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK090311, R01DK105198)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Keywords
liver innervation, sympathetic nervous system, parasympathetic nervous system, sensory nerves, liver regeneration, liver disease, liver homeostasis
MeSH terms
Animals, Humans, Liver, Liver Diseases, Liver Regeneration, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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