Immunohistochemical studies on the innervation of human transplanted liver.
Abstract
The changing pattern of innervation in the human transplanted liver was studied from the day of transplantation to 5 years later. Seven liver biopsies from non-transplant controls, 37 liver biopsies from 22 transplant patients, and one of these biopsied livers removed at retransplantation, were available for the study. Sections were immunostained for protein gene product 9.5 (PGP 9.5), neurone-specific enolase (NSE), S-100 protein, and vasoactive intestinal polypeptide. NSE and PGP 9.5 demonstrated nerves most successfully in our tissues. Staining for most small nerves was reduced by day 5 post-transplantation. Scanty fine nerves could be detected from day 13 to day 241 in occasional biopsies. Consistently identifiable immunostaining of PGP 9.5 and NSE nerve fibres was again apparent in portal areas after this time in all but one case. The findings indicate that in transplanted liver limited reinnervation can eventually take place. This could be due to either proliferation of intrinsic nerves, or regrowth of extrinsic nerves, or both.
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Most studies in humans of re-innervation of transplanted organs generally indicate that there is limited sympathetic fiber re-innervation by a year or more after transplant.
“Most studies in humans of re-innervation of transplanted organs (necessarily allogenic) generally indicate that there is limited sympathetic fiber re-innervation by a year or more after transplant [36], [37].”
From Sprouted Innervation into Uterine Transplants Contributes to the Development of Hyperalgesia in a Rat Model of Endometriosis (2012) · cites this paper as [37]
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- Authors
- Dhillon, A. P., Sankey, E. A., Wang, J. H., Wightman, A. K., Mathur, S., Burroughs, A. K., & Scheuer, P. J.
- Affiliations
- The Royal Free Hospital (GB)
- Corresponding author
- Dhillon, Amar P.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 1992-06
- Volume
- 167
- Issue
- 2
- Pages
- 211-216
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2018556838
- Cited by
- 40
- References
- 23
- Citations by year
- 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2018: 1 · 2017: 1 · 2014: 1 · 2012: 1
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pathology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- liver transplantation, innervation, reinnervation, PGP 9.5, neuron-specific enolase, S-100 protein, vasoactive intestinal peptide, retransplantation
- MeSH terms
- Humans, Immunohistochemistry, Liver, Nerve Regeneration, S100 Proteins, Neuropeptides, Phosphopyruvate Hydratase, Vasoactive Intestinal Peptide, Liver Transplantation, Ubiquitin Thiolesterase
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