NASHFit: A randomized controlled trial of an exercise training program to reduce clotting risk in patients with NASH
Open accessAbstract
Background and Aims: NASH is a common disease associated with increased rates of thromboembolism (TE). Although exercise training can lessen thrombotic risk in patients with vascular disease, whether similar findings are observed in patients with NASH is open for study. Approach and Results: We conducted a 20‐week randomized controlled clinical trial involving patients with biopsy‐confirmed NASH. Patients were randomly assigned (2:1 ratio) to receive either an exercise training program or standard clinical care. The primary endpoint was change in plasminogen activator inhibitor 1 (PAI‐1) level, an established thrombotic biomarker. Twenty‐eight patients were randomly assigned (18 exercise training and 10 standard clinical care). PAI‐1 level was significantly decreased by exercise training when compared to standard clinical care (−40 ± 100 vs. +70 ± 63 ng/ml; p = 0.02). Exercise training decreased MRI proton density fat fraction (MRI‐PDFF; −4.7 ± 5.6 vs. 1.2 ± 2.8% absolute liver fat; p = 0.01); 40% of exercise subjects had a ≥30% relative reduction in MRI‐PDFF (histological response threshold) compared to 13% for standard of care (p < 0.01). Exercise training improved fitness (VO 2 peak, +3.0 ± 5.6 vs. −1.8 ± 5.1 ml/kg/min; p = 0.05) in comparison to standard clinical care. Conclusions: This clinical trial showed that, independent of weight loss or dietary change, exercise training resulted in a significantly greater decrease in thrombotic risk than standard clinical care in patients with NASH, in parallel with MRI‐PDFF reduction and improvement in fitness. Future studies are required to determine whether exercise training can directly impact patient outcomes and lower rates of TE.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Adults with biopsy-proven MASH who performed aerobic exercise training for 20 weeks were four times more likely to achieve clinically meaningful improvement in ALT (reduction ≥ 17 IU/L) and three times more likely to achieve clinically meaningful improvement in MRI-PDFF (≥ 30% relative reduction).
“the study found that adults with biopsy-proven MASH who performed aerobic exercise training for 20 weeks were four times more likely to achieve clinically meaningful improvement in ALT (reduction ≥ 17 IU/L) and three times more likely to achieve clinically meaningful improvement in MRI-PDFF (≥ 30% relative reduction) [9, 22].”
From Aerobic Exercise Training Leads to MASH Resolution as Defined by the MASH Resolution Index (2026) · cites this paper as [22]
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredNo differences were found in waist circumference for aerobic exercise interventions compared to control.
“Nine aerobic interventions reported WC [69–72, 74, 75, 78, 79, 90], but no differences were found in comparison to control”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Harris, P. A., Taylor, R., Thielke, R., Payne, J., Gonzalez, N., & Conde, J. G. (2009) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2008.08.010 · Cited by 51,384 · see citing works
Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y., Torbenson, M. S., Unalp‐Arida, A., et al. (2005) · Hepatology · doi:10.1002/hep.20701 · Cited by 10,791 · see citing works
Chalasani, N., Younossi, Z., Lavine, J. E., Charlton, M., Cusi, K., Rinella, M., Harrison, S. A., Brunt, E. M., & Sanyal, A. J. (2018) · Hepatology · doi:10.1002/hep.29367 · Cited by 7,239 · see citing works
EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease
(2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.11.004 · Cited by 4,836 · see citing works
Vilar-Gomez, E., Martinez-Perez, Y., Calzadilla-Bertot, L., Torres-Gonzalez, A., Gra-Oramas, B., Gonzalez-Fabian, L., Friedman, S. L., Diago, M., & Romero-Gomez, M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.005 · Cited by 2,492 · see citing works
Non-alcoholic fatty liver disease - a global public health perspective
Younossi, Z. M. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.10.033 · Cited by 2,149 · see citing works
Dulai, P. S., Singh, S., Patel, J., Soni, M., Prokop, L. J., Younossi, Z., Sebastiani, G., Ekstedt, M., Hagstrom, H., Nasr, P., et al. (2017) · Hepatology · doi:10.1002/hep.29085 · Cited by 1,965 · see citing works
Self-citationHarrison, S. A., Bashir, M. R., Guy, C. D., Zhou, R., Moylan, C. A., Frias, J. P., Alkhouri, N., Bansal, M. B., Baum, S., Neuschwander-Tetri, B. A., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(19)32517-6 · Cited by 802 · see citing works
Physical fitness and activity as separate heart disease risk factors: a meta-analysis
WILLIAMS, P. T. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200105000-00012 · Cited by 724 · see citing works
Visceral fat: A key mediator of steatohepatitis in metabolic liver disease
van der Poorten, D. K., Milner, K.-L., Hui, J., Hodge, A., Trenell, M., Kench, J., London, R., Peduto, T., Chisholm, D. J., & George, J. (2008) · Hepatology · doi:10.1002/hep.22350 · Cited by 633 · see citing works
Alessi, M., Peiretti, F., Morange, P., Henry, M., Nalbone, G., & Juhan-Vague, I. (1997) · Diabetes · doi:10.2337/diab.46.5.860 · Cited by 614 · see citing works
Thögersen, A. M., Jansson, J.-H., Boman, K., Nilsson, T. K., Weinehall, L., Huhtasaari, F., & Hallmans, G. (1998) · Circulation · doi:10.1161/01.cir.98.21.2241 · Cited by 602 · see citing works
Hallsworth, K., Fattakhova, G., Hollingsworth, K. G., Thoma, C., Moore, S., Taylor, R., Day, C. P., & Trenell, M. I. (2011) · Gut · doi:10.1136/gut.2011.242073 · Cited by 529 · see citing works
Obesity, haemostasis and the fibrinolytic system
Mertens, I. L., & Gaal, L. F. V. (2002) · Obesity Reviews · doi:10.1046/j.1467-789x.2002.00056.x · Cited by 368 · see citing works
Meltzer, M. E., Lisman, T., de Groot, P. G., Meijers, J. C. M., le Cessie, S., Doggen, C. J. M., & Rosendaal, F. R. (2010) · Blood · doi:10.1182/blood-2010-02-267740 · Cited by 363 · see citing works
Loomba, R. S., Lim, J. K., Patton, H. M., & El‐Serag, H. B. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.12.053 · Cited by 360 · see citing works
Self-citationPatel, K., Harrison, S. A., Elkhashab, M., Trotter, J. F., Herring, R., Rojter, S. E., Kayali, Z., Wong, V. W., Greenbloom, S., Jayakumar, S., et al. (2020) · Hepatology · doi:10.1002/hep.31205 · Cited by 347 · see citing works
Stine, J. G., Wentworth, B. J., Zimmet, A., Rinella, M. E., Loomba, R., Caldwell, S. H., & Argo, C. K. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14937 · Cited by 336 · see citing works
Self-citationStine, J. G., Munaganuru, N., Barnard, A., Wang, J. L., Kaulback, K., Argo, C. K., Singh, S., Fowler, K. J., Sirlin, C. B., & Loomba, R. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.08.061 · Cited by 283 · see citing works
Self-citationStratton, J., Chandler, W. L., Schwartz, R. S., Cerqueira, M., Levy, W. C., Kahn, S. E., Larson, V., Cain, K. C., Beard, J. C., & Abrass, I. B. (1991) · Circulation · doi:10.1161/01.cir.83.5.1692 · Cited by 246 · see citing works
NASH Predicts Plasma Inflammatory Biomarkers Independently of Visceral Fat in Men
Targher, G., Bertolini, L., Rodella, S., Lippi, G., Franchini, M., Zoppini, G., Muggeo, M., & Day, C. P. (2008) · Obesity · doi:10.1038/oby.2008.64 · Cited by 214 · see citing works
Houghton, D., Thoma, C., Hallsworth, K., Cassidy, S., Hardy, T., Burt, A. D., Tiniakos, D., Hollingsworth, K. G., Taylor, R., Day, C. P., et al. (2017) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.07.031 · Cited by 209 · see citing works
Hallsworth, K., Thoma, C., Hollingsworth, K. G., Cassidy, S., Anstee, Q. M., Day, C. P., & Trenell, M. I. (2015) · Clinical Science · doi:10.1042/cs20150308 · Cited by 201 · see citing works
Effect of resistance training on non-alcoholic fatty-liver disease a randomized-clinical trial
Zelber-Sagi, S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i15.4382 · Cited by 152 · see citing works
Exercise and Training Effects on Blood Haemostasis in Health and Disease
Elsayed, M., Ali, Z. E.-S., & Ahmadizad, S. (2004) · Sports Medicine · doi:10.2165/00007256-200434030-00004 · Cited by 151 · see citing works
Multicenter Validation of Association Between Decline in MRI‐PDFF and Histologic Response in NASH
Loomba, R. S., Neuschwander‐Tetri, B. A., Sanyal, A. J., Chalasani, N., Diehl, A. M., Terrault, N. A., Kowdley, K. V., Dasarathy, S., Kleiner, D. E., Behling, C. A., et al. (2020) · Hepatology · doi:10.1002/hep.31121 · Cited by 151 · see citing works
Self-citationOh, S., So, R., Shida, T., Matsuo, T., Kim, B., Akiyama, K., Isobe, T., Okamoto, Y., Tanaka, K., & Shoda, J. (2017) · Scientific Reports · doi:10.1038/srep43029 · Cited by 146 · see citing works
Plasminogen Activator Inhibitor-1 and Thrombotic Cerebrovascular Diseases
Tjärnlund‐Wolf, A., Brogren, H., Lo, E. H., & Wang, X. (2012) · Stroke · doi:10.1161/strokeaha.111.622217 · Cited by 139 · see citing works
Alexopoulos, A., Crowley, M. J., Wang, Y., Moylan, C. A., Guy, C. D., Henao, R., Piercy, D. L., Seymour, K. A., Sudan, R., Portenier, D. D., et al. (2021) · Hepatology · doi:10.1002/hep.31806 · Cited by 135 · see citing works
Stine, J., Shah, N. L., Argo, C., Pelletier, S. J., Caldwell, S., & Northup, P. (2015) · Liver transplantation · doi:10.1002/lt.24134 · Cited by 133 · see citing works
Self-citationWomack, C. J., Nagelkirk, P. R., & Coughlin, A. M. (2003) · Sports Medicine · doi:10.2165/00007256-200333110-00002 · Cited by 116 · see citing works
Exercise training reverses endothelial dysfunction in nonalcoholic fatty liver disease
Pugh, C. J. A., Sprung, V. S., Kemp, G. J., Richardson, P., Shojaee-Moradie, F., Umpleby, A. M., Green, D. J., Cable, N. T., Jones, H., & Cuthbertson, D. J. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00306.2014 · Cited by 116 · see citing works
Shojaee-Moradie, F., Cuthbertson, D. J., Barrett, M., Jackson, N. C., Herring, R., Thomas, E. L., Bell, J., Kemp, G. J., Wright, J., & Umpleby, A. M. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2353 · Cited by 116 · see citing works
Sargeant, J. A., Gray, L. J., Bodicoat, D. H., Willis, S. A., Stensel, D. J., Nimmo, M. A., Aithal, G. P., & King, J. A. (2018) · Obesity Reviews · doi:10.1111/obr.12719 · Cited by 105 · see citing works
Improvement in histological endpoints of MAFLD following a 12-week aerobic exercise intervention
O’Gorman, P., Naimimohasses, S., Monaghan, A., Kennedy, M., Melo, A. M., Ní Fhloinn, D., Doherty, D. G., Beddy, P., Finn, S. P., Moore, J. B., et al. (2020) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15989 · Cited by 94 · see citing works
Majzoub, A. M., Nayfeh, T., Barnard, A., Munaganuru, N., Dave, S., Singh, S., Murad, M. H., & Loomba, R. (2021) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16583 · Cited by 92 · see citing works
Self-citationControl Group Design, Contamination and Drop-Out in Exercise Oncology Trials: A Systematic Review
Bisschop, C. N. S., Courneya, K. S., Velthuis, M. J., Monninkhof, E. M., Jones, L. W., Friedenreich, C. M., van der Wall, E., Peeters, P. H. M., & May, A. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120996 · Cited by 89 · see citing works
Stine, J., Niccum, B. A., Zimmet, A. N., Intagliata, N., Caldwell, S., Argo, C., & Northup, P. (2018) · Clinical and Translational Gastroenterology · doi:10.1038/s41424-018-0002-y · Cited by 74 · see citing works
Self-citationWang, S.-T., Zheng, J., Peng, H.-W., Cai, X.-L., Pan, X.-T., Li, H.-Q., Hong, Q.-Z., & Peng, X.-E. (2020) · BMC Gastroenterology · doi:10.1186/s12876-020-01204-3 · Cited by 68 · see citing works
Exercise training enhances endogenous fibrinolysis in peripheral arterial disease
Killewich, L. A., Macko, R. F., Montgomery, P. S., Wiley, L. A., & Gardner, A. W. (2004) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2004.07.030 · Cited by 55 · see citing works
Exercise as Medicine: The Impact of Exercise Training on Nonalcoholic Fatty Liver Disease
Thorp, A., & Stine, J. G. (2020) · Current Hepatology Reports · doi:10.1007/s11901-020-00543-9 · Cited by 52 · see citing works
Self-citationCirrhosis is Associated with an Increased 30-Day Mortality After Venous Thromboembolism
Søgaard, K. K., Horváth–Puhó, E., Montomoli, J., Vilstrup, H., & Sørensen, H. T. (2015) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2015.27 · Cited by 48 · see citing works
Effects of exercise training on plasminogen activator inhibitor activity
de Geus, E. J. C., Kluft, C., de Bart, A. C. W., & van Doornen, L. J. P. (1992) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199211000-00004 · Cited by 46 · see citing works
Stine, J., Argo, C., Pelletier, S., Maluf, D., Caldwell, S., & Northup, P. (2017) · World Journal of Hepatology · doi:10.4254/wjh.v9.i3.139 · Cited by 43 · see citing works
Self-citationSudi, K. M., Gallistl, S., Tröbinger, M., Payerl, D., Weinhandl, G., Muntean, W. E., Aigner, R., & Borkenstein, M. H. (2001) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2001.14.1.85 · Cited by 35 · see citing works
Elsayed, M. (1996) · Blood Coagulation & Fibrinolysis · doi:10.1097/00001721-199606000-00009 · Cited by 32 · see citing works
Tang, J., Zhu, W., Mei, X., & Zhang, Z. (2018) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-018-0716-2 · Cited by 30 · see citing works
Nonalcoholic Fatty Liver Disease-Evidence for a Thrombophilic State?
Spinosa, M., & Stine, J. G. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200131101553 · Cited by 29 · see citing works
Self-citationAerobic capacity and exercise performance in nonalcoholic fatty liver disease
Austin, P. W., Gerber, L. H., Paik, J. M., Price, J. K., Escheik, C., & Younossi, Z. M. (2019) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.19.09231-4 · Cited by 25 · see citing works
Stine, J. G., Schreibman, I., Navabi, S., Kang, M., Dahmus, J., Soriano, C., Rivas, G., Hummer, B., Beyer, M., Tressler, H., et al. (2020) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2020.100560 · Cited by 19 · see citing works
Self-citationAge and aerobic training status effects on plasma and skeletal muscle tPA and PAI-1
Francis, R. M., Romeyn, C. L., Coughlin, A. M., Nagelkirk, P. R., Womack, C. J., & Lemmer, J. T. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2857-2 · Cited by 17 · see citing works
Resting and Exercise Energy Metabolism After Liver Transplantation for Nonalcoholic Steatohepatitis
Singhvi, A., Sadowsky, H. S., Cohen, A., Demzik, A. L., VanWagner, L. B., Rinella, M. E., & Levitsky, J. (2017) · Transplantation Direct · doi:10.1097/txd.0000000000000701 · Cited by 14 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [37]Piantadosi S Clinical Trials: A Methodologic Perspective, Third Edition. Hoboken, NJ: John Wiley & Sons, Inc. 2017.
Cited by
Sorted by citations
Metabolic dysfunction-associated steatotic liver disease in adults
Huang, D. Q., Wong, V. W., Rinella, M. E., Boursier, J., Lazarus, J. V., Yki‐Järvinen, H., & Loomba, R. S. (2025) · Nature Reviews Disease Primers · doi:10.1038/s41572-025-00599-1 · Cited by 336 · see citing works
Self-citationKeating, S. E., Sabag, A., Hallsworth, K., Hickman, I. J., Macdonald, G. A., Stine, J. G., George, J., & Johnson, N. A. (2023) · Sports Medicine · doi:10.1007/s40279-023-01918-w · Cited by 119 · see citing works
Self-citationStine, J. G., DiJoseph, K., Pattison, Z., Harrington, A., Chinchilli, V. M., Schmitz, K. H., & Loomba, R. (2023) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002098 · Cited by 94 · see citing works
Self-citationStine, J. G., Long, M. T., Corey, K. E., Sallis, R. E., Allen, A. M., Armstrong, M. J., Conroy, D. E., Cuthbertson, D. J., Duarte-Rojo, A., Hallsworth, K., et al. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000108 · Cited by 89 · see citing works
Self-citationSkeletal muscle and MASLD: Mechanistic and clinical insights
Marjot, T., Armstrong, M. J., & Stine, J. G. (2025) · Hepatology Communications · doi:10.1097/hc9.0000000000000711 · Cited by 73 · see citing works
Self-citationXue, Y., Peng, Y., Zhang, L., Ba, Y., Jin, G., & Liu, G. (2024) · Scientific Reports · doi:10.1038/s41598-024-51470-4 · Cited by 52 · see citing works
The Role of Exercise in Steatotic Liver Diseases: An Updated Perspective
Razzak, I. A., Fares, A., Stine, J. G., & Trivedi, H. D. (2024) · Liver International · doi:10.1111/liv.16220 · Cited by 46 · see citing works
Self-citationStine, J. G., Long, M. T., Corey, K. E., Sallis, R. E., Allen, A. M., Armstrong, M. J., Conroy, D. E., Cuthbertson, D. J., Duarte‐Rojo, A., Hallsworth, K., et al. (2023) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003199 · Cited by 44 · see citing works
Self-citationKeating, S. E., Chawla, Y. K., De, A., & George, E. S. (2024) · Hepatology International · doi:10.1007/s12072-024-10663-9 · Cited by 43 · see citing works
Vilar-Gomez, E., Vuppalanchi, R., Gawrieh, S., Pike, F., Samala, N., & Chalasani, N. (2023) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002222 · Cited by 39 · see citing works
Arita, V. A., Cabezas, M. C., Hernández Vargas, J. A., Trujillo-Cáceres, S. J., Mendez Pernicone, N., Bridge, L. A., Raeisi-Dehkordi, H., Dietvorst, C. A. W., Dekker, R., Uriza-Pinzón, J. P., et al. (2025) · BMC Medicine · doi:10.1186/s12916-025-04320-7 · Cited by 43 · see citing works
Keating, S. E., Croci, I., Wallen, M. P., Cox, E. R., Thuzar, M., Pham, U. P., Mielke, G. I., Coombes, J. S., Macdonald, G. A., & Hickman, I. J. (2022) · Digestive Diseases and Sciences · doi:10.1007/s10620-022-07779-z · Cited by 39 · see citing works
Cuthbertson, D. J., Keating, S. E., Pugh, C. J. A., Owen, P. J., Kemp, G. J., Umpleby, M., Geyer, N. G., Chinchilli, V. M., & Stine, J. G. (2024) · Liver International · doi:10.1111/liv.15947 · Cited by 38 · see citing works
Self-citationThe steatotic liver disease burden paradox: unravelling the key role of alcohol
Torp, N., Israelsen, M. E., & Krag, A. A. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-01022-y · Cited by 39 · see citing works
Stine, J. G., Rivas, G., Hummer, B. L., Duarte‐Rojo, A., May, C. N., Geyer, N. R., Chinchilli, V. M., Conroy, D. E., Mitchell, E. S., McCallum, M., et al. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000052 · Cited by 37 · see citing works
Self-citationKang, S., Kang, S. M., Choi, J. H., Ko, S., Koo, B. K., Kwon, H.-S., Kim, M. K., Kim, S. Y., Kim, S., Kim, Y., et al. (2025) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2025.0469 · Cited by 42 · see citing works
Harris, S. J., Smith, N., Hummer, B., Schreibman, I. R., Faust, A. J., Geyer, N. R., Chinchilli, V. M., Sciamanna, C., Loomba, R., & Stine, J. G. (2024) · Liver International · doi:10.1111/liv.15769 · Cited by 31 · see citing works
Self-citationHepatic Klf10-Fh1 axis promotes exercise-mediated amelioration of NASH in mice
Luo, H.-Y., Mu, W.-J., Chen, M., Zhu, J., Li, Y., Li, S., Yan, L.-J., Li, R.-Y., Yin, M.-T., Li, X., et al. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155916 · Cited by 28 · see citing works
Human genetics of steatotic liver disease: insights into insulin resistance and lipid metabolism
Mancina, R. M., Valenti, L. V. C., & Romeo, S. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01394-8 · Cited by 28 · see citing works
The Basics of Metabolic Dysfunction–Associated Steatotic Liver Disease for Cardiologists
Khan, M. S., Javaid, S. S., Dinani, A. M., Wegermann, K., Pandey, A., Bhatt, A. S., Muthiah, M. D., Spall, H. G. C. V., Zannad, F. M., Butler, J., et al. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.08.100 · Cited by 20 · see citing works
Stine, J. G., Welles, J. E., Keating, S. E., Hussaini, Z., Soriano, C. T., Heinle, J. W., Geyer, N. R., Chinchilli, V. M., Loomba, R. S., & Kimball, S. R. (2023) · Nutrients · doi:10.3390/nu15061481 · Cited by 17 · see citing works
Self-citationAlbhaisi, S. A. M., Tondt, J., Cyrus, J. W. W., Chinchilli, V. M., Conroy, D. E., & Stine, J. G. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000499 · Cited by 16 · see citing works
Self-citationChen, G., Banini, B. A., Do, A., Gunderson, C., Zaman, S., & Lim, J. K. (2023) · Genes · doi:10.3390/genes14091811 · Cited by 15 · see citing works
“…serum and Although previous RCTs have shown that exercise independently improves serum and imaging-based markers of hepatic steatosis and fi brosis [8,9], our fi ndings suggest that exercise alone does not signi fi cantly impact Brunt grade, NAS, or liver fi brosis. imaging-based markers of hepatic…”
BackgroundZafar, Y., Sohail, M. U., Saad, M., Ahmed, S. Z., Sohail, M. O., Zafar, J., Lirette, S. T., & Singal, A. K. (2025) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2024-001670 · Cited by 14 · see citing works
Khalafi, M., Fatolahi, S., Symonds, M. E., Dinizadeh, F., Rosenkranz, S. K., & Batrakoulis, A. (2025) · Obesity Reviews · doi:10.1111/obr.70031 · Cited by 13 · see citing works
Fabris, L., Campello, E., Cadamuro, M., & Simioni, P. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166763 · Cited by 13 · see citing works
Alonso‐Peña, M., Barrio, M. D., Peleteiro‐Vigil, A., Jiménez-González, C., Santos‐Laso, Á., Arias, M., Iruzubieta, P., & Crespo, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310718 · Cited by 14 · see citing works
Wang, H., Ma, Q., Chen, Y., Luo, L., Ye, J., & Zhong, B. (2024) · Obesity Reviews · doi:10.1111/obr.13727 · Cited by 13 · see citing works
Chen, G., Banini, B. A., Do, A., & Lim, J. K. (2022) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2022.0366 · Cited by 10 · see citing works
Dahmus, J., Hummer, B. L., Rivas, G., Schmitz, K. H., Caldwell, S. H., Argo, C. K., Schreibman, I. R., & Stine, J. G. (2023) · Digestive Diseases and Sciences · doi:10.1007/s10620-022-07809-w · Cited by 9 · see citing works
Self-citationTan, X., Zou, H., Guo, M., Liu, J., Huang, X., Yu, R., Liu, X., & Qin, C. (2026) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2026.101125 · Cited by 8 · see citing works
Nutrition in MASLD: a patient focused, evidence-based clinician’s guide
Pekarska, K., Brennan, P. N., Wajcman, D. I., Towey, J., Cox, L., Weatherby, K., McPherson, S., Stine, J., Willemse, J., Li, W., et al. (2025) · Frontline Gastroenterology · doi:10.1136/flgastro-2025-103183 · Cited by 7 · see citing works
Self-citationTamaki, N., Kimura, T., Wakabayashi, S., Yamazaki, T., Iwadare, T., Tanaka, N., & Kurosaki, M. (2026) · Japanese Journal of Radiology · doi:10.1007/s11604-025-01930-2 · Cited by 8 · see citing works
Khalafi, M., Fatolahi, S., Symonds, M. E., Rosenkranz, S. K., Dinizadeh, F., & Batrakoulis, A. (2025) · Obesity Reviews · doi:10.1111/obr.70052 · Cited by 6 · see citing works
Stine, J. G., & Loomba, R. S. (2022) · Clinical Liver Disease · doi:10.1002/cld.1249 · Cited by 6 · see citing works
Self-citationWang, B., Zeng, X., Deng, H., Qiu, B., Xu, K., Tao, M., Zhang, Y., Zheng, H., Xu, Q., Li, S., et al. (2026) · Metabolism · doi:10.1016/j.metabol.2026.156677 · Cited by 6 · see citing works
Analyzing MASLD interventional clinical trial registration based on the ClinicalTrials.gov database
Du, H., Huang, J., Wang, Y., Wang, C., Wang, Y., Hou, L., Li, Y., Li, Y., & Su, Q. (2025) · BMC Gastroenterology · doi:10.1186/s12876-025-03732-2 · Cited by 5 · see citing works
Keating, S. E., Owen, P. J., Pugh, C. J. A., Cuthbertson, D. J., & Stine, J. G. (2025) · Hepatology Communications · doi:10.1097/hc9.0000000000000681 · Cited by 5 · see citing works
Self-citationÇELİK, F. E., Yuksel, M., & Bektaş, H. (2026) · Western Journal of Nursing Research · doi:10.1177/01939459251400493 · Cited by 4 · see citing works
Sogbe, M., Hummer, B. L., Stine, J. G., Lizaola‐Mayo, B., Forman, D. E., Vargas, H. E., & Duarte‐Rojo, A. (2025) · Digestive Diseases and Sciences · doi:10.1007/s10620-025-08893-4 · Cited by 4 · see citing works
Self-citationLisco, G., Guido, D., Cerabino, N., Chito, M. D., Donvito, R., Bonfiglio, C., Shahini, E., Zappimbulso, M., Randazzo, C., Barletta, D., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06464-9 · Cited by 4 · see citing works
Choi, C., & Simonetto, D. A. (2022) · Clinical Liver Disease · doi:10.1002/cld.1253 · Cited by 4 · see citing works
Román-Calleja, B. M., Ruiz‐Margáin, A., Duarte‐Rojo, A., Flores-Silva, F., Martinez-Cabrera, C. F., Gutierrez-Rosas, L. E., Valencia-Peña, B. A., Cantú-Brito, C. G., Chalasani, N., Aguilar-Salinas, C. A., et al. (2025) · Liver Transplantation · doi:10.1097/lvt.0000000000000767 · Cited by 4 · see citing works
Letter to the editor: Is PAI‐1 a thrombotic biomarker in NASH cirrhosis?
Zanetto, A., Campello, E., Spiezia, L., Burra, P., Simioni, P., & Senzolo, M. (2022) · Hepatology · doi:10.1002/hep.32392 · Cited by 3 · see citing works
Aerobic Exercise Training Leads to MASH Resolution as Defined by the MASH Resolution Index
Channapragada, T., Batra, S., Hummer, B. L., Chinchilli, V. M., Huang, D., Loomba, R., Schreibman, I. R., & Stine, J. G. (2026) · Digestive Diseases and Sciences · doi:10.1007/s10620-025-09361-9 · Cited by 2 · see citing works
Self-citationJin, Y. (2023) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2023.0055 · Cited by 2 · see citing works
Stine, J. G., Hummer, B. L., Smith, N., Tressler, H., Heinle, J. W., VanKirk, K., Harris, S., Moeller, M., Luzier, G., DiJoseph, K., et al. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000464 · Cited by 1 · see citing works
Self-citationIchikawa, T., Miuma, S., Yamashima, M., Yamamichi, S., Koike, M., Nakano, Y., Yajima, H., Miyazaki, O., Ikeda, T., Okamura, T., et al. (2025) · Biomedical Reports · doi:10.3892/br.2025.2036 · Cited by 1 · see citing works
Improving the fitness of the NASH clinical trial: Standardizing the standard‐of‐care intervention
Kappus, M. R., Patel, Y. A., & Duarte‐Rojo, A. (2022) · Hepatology · doi:10.1002/hep.32369
Stine, J. G., Schreibman, I. R., Faust, A. J., Dahmus, J., Stern, B., Soriano, C. T., Rivas, G., Hummer, B. L., Kimball, S. R., Geyer, N. R., et al. (2022) · Hepatology · doi:10.1002/hep.32390
Self-citationOh, J. H., Park, Y., Sinn, D. H., Kang, D., Sohn, W., Jun, D. W., Ahn, S. B., & Choi, M. S. (2023) · doi:10.2196/preprints.51827
Scheiner, B., Dominik, N., & Mandorfer, M. (2024) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.18144
Gaspar, R. C., Macêdo, A. P. A., Nakandakari, S. C. B. R., Muñoz, V. R., Abud, G. F., Vieira, R. F. L., Neto, I. V. D. S., Pavan, I. C. B., da Silva, L. G. S., Simabuco, F. M., et al. (2025) · Liver International · doi:10.1111/liv.70068 · Cited by 1 · see citing works
Keating, S. E., de Boer, J., Catsoulis, G., Stine, J. G., Goode, A. D., Macdonald, G. A., Powell, E. E., & Hickman, I. J. (2025) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2025.00155
Self-citationSkeletal Muscle and Cardiovascular Health
Ruiz‐Ramie, J. J., Davis, P. G., Anderson, E., & Durstine, J. L. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-88361-3_26
Non-Alcoholic Fatty Liver Disease (NAFLD): A Review of Risk Factors, Pathogenesis, and Treatment
李, 春. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.15113368
Song, W., & Ke, Z. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1760364
Szot, A., Babicz, M., Chudzicki, K., Czyżewski, W., Danielczyk, D., Malatyńska, N., Muller, O., Pałubska, J., Rosa, K., & Słoma, A. (2026) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.1(49).2026.5326
Huang, W., He, Y., Lu, H., Wang, J., Liang, Y., Zeng, L., Li, L., Lu, H., Li, Z., Wang, Z., et al. (2026) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2026.1854220
Prescribing Exercise in MASLD: From Evidence to a Structured, Measurable Intervention
Rodriguez, L. A. M., Olivera, M. R. G., Espinosa, C. S. G., Velazquez, Y. V., Flores-Lázaro, J. R., & Torre, A. (2026) · Current Hepatology Reports · doi:10.1007/s11901-026-00740-y
Asif, M. A., Masood, S., Akbar, S. M. A., Khalid, M. H., Rehman, A., Imran, M., Suhaib, A., Asif, M. A., Khalid, A., Sohaib, M., et al. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15145737
Exerkine-Mediated Inter-Organ Crosstalk and Translational Perspectives in Metabolic Diseases
Zhou, B., Zhang, S., Zhang, Z., Ran, S., Guo, H., Wang, S., & Meng, H. (2026) · Current Obesity Reports · doi:10.1007/s13679-026-00752-1
Xu, J., Sang, K., & Zhang, J. (2026) · Metabolites · doi:10.3390/metabo16090666
Gosson, C., Megapanou, M., White, S., & Forton, D. M. (2026) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2026-002514
- Authors
- Stine, J. G., Schreibman, I. R., Faust, A. J., Dahmus, J., Stern, B., Soriano, C., Rivas, G., Hummer, B., Kimball, S. R., Geyer, N. R., Chinchilli, V. M., Loomba, R., Schmitz, K., & Sciamanna, C.
- Affiliations
- Pennsylvania State University (US)
- Department of Public Health Sciences,The Pennsylvania State University–College of Medicine,Hershey,Pennsylvania,USA
- University of California San Diego (US)
- Corresponding author
- Stine, Jonathan G.
- ORCID
- Venue
- Hepatology
- Published
- 2022-01-22
- Volume
- 76
- Issue
- 1
- Pages
- 172-185
- ISSN
- 0270-9139 (ISSN-L)
- 1527-3350
- PMC
- PMC9184303
- OpenAlex
- W4200179395
- Cited by
- 65
- References
- 52
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 10 · 2023: 13 · 2022: 8
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Pennsylvania Department of Health
- National Institutes of Health (UL1TR000127, UL1TR002014)
- National Institute of Diabetes and Digestive and Kidney Diseases (L30 DK118601)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- nonalcoholic steatohepatitis, exercise training, thromboembolic risk, plasminogen activator inhibitor-1, liver fat reduction, proton density fat fraction, peak oxygen uptake, fitness improvement, NASH treatment
- MeSH terms
- Humans, Magnetic Resonance Imaging, Thrombosis, Exercise, Plasminogen Activator Inhibitor 1, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
