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Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice
Open accessAbstract
Interleukin-6 null (IL-6−/−) mice have impaired liver regeneration and increased liver necrosis following partial hepatectomy that is corrected with IL-6 treatment. Following acute carbon tetrachloride (CCl 4) treatment, we found that IL-6−/− mice developed increased hepatocellular injury and defective regeneration with significant blunting of signal transducer-and-activator of transcription protein 3 (STAT3) and nuclear factor-κB (NF-κB) activation and reduced hepatocyte DNA synthetic and mitotic responses. After CCl 4 treatment, unlike partial hepatectomy, increased hepatocyte apoptosis was noted in IL-6−/− livers. Pretreatment with IL-6 before CCl 4 reduced acute CCl 4 injury and apoptosis and accelerated regeneration in both IL-6+/+ and −/− livers. Repetitive doses of CCl 4 in the presence or absence of phenobarbital resulted in increased injury and fibrosis in IL-6 −/− compared with +/+ livers. After acute and chronic injury, IL-6−/− livers showed the protracted presence of α-smooth muscle actin associated with activated stellate cells, indicating a disturbed response in wound healing that progressed to fibrosis. These data provide evidence for an important role for IL-6 in reducing CCl 4-induced acute and chronic liver injury and fibrosis.
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“Interestingly, several studies around 20 years ago have also shown that IL-6 protects hepatocytes from injuries.36,37”
From Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers (2023) · cites this paper as [37]
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“Increasing evidence demonstrates that IL-6 has a protective role during liver injury.”
From The IL-6–gp130–STAT3 pathway in hepatocytes triggers liver protection in T cell–mediated liver injury (2005) · cites this paper as [2]
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Cites
The American Journal of Physiology
(1899) · The American Naturalist · doi:10.1086/277182 · Cited by 5,680
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047
Michalopoulos, G. K., & DeFrances, M. C. (1997) · Science · doi:10.1126/science.276.5309.60 · Cited by 2,828
Thomas, A. C., & Campbell, J. H. (2000) · Cited by 2,800
Lethal effect of the anti-Fas antibody in mice
Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., & Nagata, S. (1993) · Nature · doi:10.1038/364806a0 · Cited by 1,881
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S., & Baltimore, D. (1995) · Nature · doi:10.1038/376167a0 · Cited by 1,828
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., & Köhler, G. (1994) · Nature · doi:10.1038/368339a0 · Cited by 1,768
Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice
Cressman, D. E., Greenbaum, L. E., DeAngelis, R. A., Ciliberto, G., Furth, E. E., Poli, V., & Taub, R. (1996) · Science · doi:10.1126/science.274.5291.1379 · Cited by 1,538
Self-citationProtease activation during apoptosis: Death by a thousand cuts?
Martin, S. J., & Green, D. R. (1995) · Cell · doi:10.1016/0092-8674(95)90422-0 · Cited by 1,305
Tissue-specific in vitro transcription from the mouse albumin promoter
Gorski, K., Carneiro, M., & Schibler, U. (1986) · Cell · doi:10.1016/0092-8674(86)90519-2 · Cited by 1,227
Flagged first, then by citations
Research works printed but not linked: 10
- Yamada, 1998, Am J Pathol, 152, 1577
- Liu, 1995, Hepatology, 22, 1474
- Brenner, 1993, Hepatology, 17, 287
- Recknegal, CRC Crit Rev Toxicol, 2, 68
- Olufemi Willaims, 1996, Hepatology, 23, 1268
- Grasl-Kraupp, 1995, Hepatology, 21, 1465
- Wroblewski, Am J Med, 27, 341
- Ravi, 1998, Cancer Research, 58, 882
- Schwarze, 1995, Cancer Research, 55, 2262
- Johnson, 1993, Internat J. Exp. Pathol, 74, 325
Cited by
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Items 101–200 of 296
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Naseem, S., Hussain, T., & Manzoor, S. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.01.002 · Cited by 72
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Cong, M., Iwaisako, K., Jiang, C., & Kisseleva, T. (2012) · International Journal of Hepatology · doi:10.1155/2012/158547 · Cited by 74
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Hu, Z., Han, Y., Liu, Y., Zhao, Z., Ma, F., Cui, A., Zhang, F., Liu, Z., Xue, Y., Bai, J., et al. (2020) · Hepatology · doi:10.1002/hep.30919 · Cited by 65
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Mair, M. (2011) · Frontiers in bioscience · doi:10.2741/3886 · Cited by 64
Horiguchi, N., Lafdil, F., Miller, A. M., Park, O., Wang, H., Rajesh, M., Mukhopadhyay, P., Fu, X. Y., Pacher, P., & Gao, B. (2010) · Hepatology · doi:10.1002/hep.23532 · Cited by 65
Liu, Y., Liu, A., Li, H., Li, C., & Lin, J. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0317 · Cited by 65
Normal Liver Regeneration in P50/Nuclear Factor κB1 Knockout Mice
DeAngelis, R. A., Kovalovich, K. K., Cressman, D. E., & Taub, R. A. (2001) · Hepatology · doi:10.1053/jhep.2001.23192 · Cited by 66
Self-citationRole of interleukin-6 in regulation of immune responses to remodeling after myocardial infarction
Huang, M., Du, Y., Xiang, M., & Wang, J. (2014) · Heart Failure Reviews · doi:10.1007/s10741-014-9431-1 · Cited by 67
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Feng, D., Wang, Y., Wang, H., Weng, H., Kong, X., Martin-Murphy, B. V., Li, Y., Park, O., Dooley, S., Ju, C., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400588 · Cited by 63
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Ebrahimi, H., Naderian, M., & Sohrabpour, A. A. (2016) · Middle East Journal of Digestive Diseases · doi:10.15171/mejdd.2016.29 · Cited by 61
Upadhyaya, R., Sharma, V. K., & Anita, K. V. (2011) · Cited by 62
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Kobayashi, K., Kuroda, J., Shibata, N., Hasegawa, T., Seko, Y., Satoh, M., Tohyama, C., Takano, H., Imura, N., Sakabe, K., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.112912 · Cited by 58
Alabraba, E., Lai, V., Boon, L., Wigmore, S. J., Adams, D., & Afford, S. C. (2007) · Hepatology · doi:10.1002/hep.22011 · Cited by 58
Cheng, L., Wang, J., Li, X., Xing, Q. R., Du, P., Su, L., & Wang, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017631 · Cited by 55
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Knight, D. A., Mutsaers, S. E., & Prêle, C. M. (2010) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2010.10.005 · Cited by 55
Nan, Y., Kong, L.-B., Ren, W., Wang, R., Du, J., Li, W., Zhao, S., Zhang, Y., Wu, W., Di, H., et al. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-11 · Cited by 55
Self-citationLipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice
Su, G. L., Gong, K. Q., Fan, M. H., Kelley, W. M., Hsieh, J. K., Sun, J. M., Hemmila, M. R., Arbabi, S., Remick, D. G., & Wang, S. C. (2005) · Hepatology · doi:10.1002/hep.20533 · Cited by 55
Chen, X., Meng, Q., Wang, C., Liu, Q., Sun, H., Huo, X., Sun, P., Yang, X., Peng, J., & Liu, K. (2014) · Pharmaceutical Research · doi:10.1007/s11095-014-1483-3 · Cited by 53
Matsumoto, T., O’Malley, K. A., Efron, P. A., Burger, C., McAuliffe, P. F., Scumpia, P. O., Uchida, T., Tschoeke, S. K., Fujita, S., Moldawer, L. L., et al. (2006) · Surgery · doi:10.1016/j.surg.2006.04.010 · Cited by 51
Han, C. L., Bowen, W. C., Michalopoulos, G. K., & Wu, T. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21420 · Cited by 52
Immunotoxicology: role of inflammation in chemical-induced hepatotoxicity
Luster, M. I., Simeonova, P. P., Gallucci, R. M., Matheson, J. M., & Yücesoy, B. (2000) · International Journal of Immunopharmacology · doi:10.1016/s0192-0561(00)00073-4 · Cited by 50
Ng, V. L., Sabla, G. E., Melín‐Aldana, H., Kelley‐Loughnane, N., Degen, J. L., & Bezerra, J. A. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00212-4 · Cited by 49
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Huang, Y. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i9.1386 · Cited by 49
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Stockert, J., Adhikary, T., Kaddatz, K., Finkernagel, F., Meißner, W., Müller‐Brüsselbach, S., & Müller, R. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq773 · Cited by 48
Lukashevich, I. S., Rodas, J. D., Tikhonov, I. I., Zapata, J. C., Yang, Y., Djavani, M. M., & Salvato, M. S. (2004) · Archives of Virology · doi:10.1007/s00705-004-0385-9 · Cited by 47
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Andersen, K. J., Knudsen, A. R., Kannerup, A.-S., Sasanuma, H., Nyengaard, J. R., Hamilton-Dutoit, S. J., Erlandsen, E. J., Jørgensen, B., & Mortensen, F. V. (2013) · International Journal of Surgery · doi:10.1016/j.ijsu.2013.07.009 · Cited by 48
Luckey, S. W., Taylor, M. S., Sampey, B. P., Scheinman, R. I., & Petersen, D. R. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.033522 · Cited by 46
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Chi, G., Feng, X., Ru, Y.-X., Xiong, T., Gao, Y. H., Wang, H., Luo, Z., Mo, R., Guo, F., He, Y., et al. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.05.005 · Cited by 45
Bosserhoff, A., Moser, M., Schölmerich, J., Buettner, R., & Hellerbrand, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212639200 · Cited by 43
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Nie, Q. (2001) · World Journal of Gastroenterology · doi:10.3748/wjg.v7.i3.363 · Cited by 44
Tachibana, S., Zhang, X., Ito, K., Ota, Y., Cameron, A. M., Williams, G. M., & Sun, Z. (2014) · Cell & Bioscience · doi:10.1186/2045-3701-4-6 · Cited by 43
Roy, S., Sannigrahi, S., Majumdar, S., Ghosh, B., & Sarkar, B. (2011) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2011/703676 · Cited by 44
Hayashi, H., Nagaki, M., Imose, M., Osawa, Y., Kimura, K., Takai, S., Imao, M., Naiki, T., Kato, T., & Moriwaki, H. (2005) · Liver International · doi:10.1111/j.1478-3231.2005.01029.x · Cited by 44
Yang, X., Schaper, F., Teubner, A., Lammert, F., Heinrich, P. C., Matern, S., & Siewert, E. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.02.048 · Cited by 41
Fareed, M. M., Khalid, H., Khalid, S., & Shityakov, S. (2023) · Current Molecular Medicine · doi:10.2174/0115665240257603230919103539 · Cited by 45
Koike, K., Ueda, S., Yamagishi, S., Yasukawa, H., Kaida, Y., Yokoro, M., Fukami, K., Yoshimura, A., & Okuda, S. (2013) · Clinical Immunology · doi:10.1016/j.clim.2013.11.003 · Cited by 39
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Self-citationDebonera, F., Krasinkas, A. M., Gelman, A. E., Aldeguer, X., Que, X., Shaked, A. A., & Olthoff, K. M. (2003) · Hepatology · doi:10.1016/j.hep.2003.09.036 · Cited by 39
Sudo, K., Yamada, Y., Saito, K., Shimizu, S., Ohashi, H., Kato, T., Moriwaki, H., Ito, H., & Seishima, M. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.09.010 · Cited by 38
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Shriki, A., Lanton, T., Sonnenblick, A., Levkovitch-Siany, O., Eidelshtein, D., Abramovitch, R., Rosenberg, N., Pappo, O., Elgavish, S., Nevo, Y., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0321 · Cited by 34
Hepatic injury due to drugs, herbal compounds, chemicals and toxins
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Graf, D., Kohlmann, C., Haselow, K., Gehrmann, T., Bode, J. G., & Häussinger, D. (2006) · Hepatology · doi:10.1002/hep.21368 · Cited by 32
Minamino, T., Ito, Y., Ohkubo, H., Hosono, K., Suzuki, T., Sato, T., Ae, T., Shibuya, A., Sakagami, H., Narumiya, S., et al. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.12.013 · Cited by 33
Zahedi, K. A., Barone, S., Xu, J., Steinbergs, N., Schuster, R. M., Lentsch, A. B., Amlal, H., Wang, J., Casero, R. A., & Soleimani, M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00431.2011 · Cited by 32
Progress and Prospects of Non-Canonical NF-κB Signaling Pathway in the Regulation of Liver Diseases
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Hepatic ILC2 activity is regulated by liver inflammation-induced cytokines and effector CD4+ T cells
Steinmann, S., Schoedsack, M., Heinrich, F., Breda, P. C., Ochel, A., Tiegs, G., & Neumann, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-57985-w · Cited by 32
Gao, B. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.07.006 · Cited by 31
Huang, Y., Chuang, J., Yang, Y., Huang, C., Wu, C.-L., & Chen, C. (2009) · Laboratory Investigation · doi:10.1038/labinvest.2009.82 · Cited by 30
Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity
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Riordan, S. M., Skinner, N. A., McIver, C. J., Liu, Q., Bengmark, S., Bihari, D. J., & Visvanathan, K. (2007) · Microbial Ecology in Health and Disease · doi:10.1080/08910600601178709 · Cited by 29
Shinoda, M., Tilles, A. W., Kobayashi, N., Wakabayashi, G., Takayanagi, A., Totsugawa, T., Harada, H., Obara, H., Suganuma, K., Francois Berthiaume, B., et al. (2006) · Journal of Surgical Research · doi:10.1016/j.jss.2006.08.009 · Cited by 29
Obayashi, Y., Arisaka, H., Yoshida, S., Mori, M., & Takahashi, M. (2012) · Amino Acids · doi:10.1007/s00726-012-1317-8 · Cited by 28
Lanton, T., Shriki, A., Nechemia‐Arbely, Y., Abramovitch, R., Levkovitch‐Siany, O., Adar, R., Rosenberg, N., Paldor, M., Goldenberg, D., Sonnenblick, A., et al. (2016) · Hepatology · doi:10.1002/hep.29004 · Cited by 28
Mutengo, M. M., Mduluza, T., Kelly, P. M., Mwansa, J. C. L., Kwenda, G., Musonda, P., & Chipeta, J. (2018) · Journal of Parasitology Research · doi:10.1155/2018/9754060 · Cited by 27
Tharappel, J. C., Cunningham, M. L., Spear, B. T., & Glauert, H. P. (2001) · Toxicological Sciences · doi:10.1093/toxsci/62.1.20 · Cited by 28
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Nawaz, R., Zahid, S., Idrees, M., Rafique, S., Shahid, M., Ahad, A., Amin, I., Almas, I., & Afzal, S. (2017) · Inflammation Research · doi:10.1007/s00011-017-1029-3 · Cited by 28
Kang, Y. H., Francois Berthiaume, B., & Yarmush, M. L. (2002) · Tissue Engineering · doi:10.1089/107632702760240599 · Cited by 26
Jing, L., Zong, S., Li, J., Ye, M., Surhio, M. M., & Yang, L. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.06.057 · Cited by 25
Wong, S., Ting, Y., Yong, Y.-K., Tan, H.-Y., Barathan, M., Riazalhosseini, B., Bee, C. J., Tee, K. K., Larsson, M., Velu, V., et al. (2021) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2021.1876245 · Cited by 28
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Chida, Y., Sudo, N., Motomura, Y., & Kubo, C. (2004) · NeuroImmunoModulation · doi:10.1159/000080153 · Cited by 24
Kleiner, D. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-7020-6697-9.00012-1 · Cited by 24
Opposing roles of STAT1 and STAT3 in T cell–mediated hepatitis: regulation by SOCS
Hong, F., Jaruga, B., Kim, W. H., Radaeva, S., El-Assal, O. N., Tian, Z., Nguyen, V.-A., & Gao, B. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215841 · Cited by 22
Dose-dependent induction of IL-6 by plant-derived proteasesin vitro
Rose, B., Herder, C., Löffler, H., Meierhoff, G., Schloot, N. C., Walz, M., & Martin, S. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02970.x · Cited by 23
Zhang, L. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i17.2574 · Cited by 23
Kaden, T., Graf, K., Rennert, K., Li, R., Mosig, A. S., & Raasch, M. (2023) · Scientific Reports · doi:10.1038/s41598-023-40004-z · Cited by 23
Nakagawa, H., Fujiwara, N., Tateishi, R., Arano, T., Nakagomi, R., Kondo, M., Minami, T., Sato, M., Uchino, K., Enooku, K., et al. (2014) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12719 · Cited by 22
The effects and mechanism of Aronia melanocarpa Elliot anthocyanins on hepatic fibrosis
Yang, J., Gao, J., Yu, W., Hao, R., Fan, J., & Wei, J. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103897 · Cited by 22
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Li, Q. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i16.2438 · Cited by 22
Liu, W. (2003) · World Journal of Gastroenterology · doi:10.3748/wjg.v9.i2.316 · Cited by 22
Kučera, O., Lotková, H., Staňková, P., Podhola, M., Roušar, T., Mezera, V., & Červinková, Z. (2011) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2011.00765.x · Cited by 21
Han, X., Liu, J., Bai, Y., Hang, A., Lu, T., & Mao, C. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104488 · Cited by 21
Wang, X., & Ning, Q. (2014) · Europe PMC (PubMed Central) · doi:10.17877/de290r-6940 · Cited by 23
Knudsen, A. R., Kannerup, A.-S., Grønbæk, H., Hamilton-Dutoit, S. J., Nyengaard, J. R., Funch-Jensen, P. M., & Mortensen, F. V. (2012) · Journal of Surgical Research · doi:10.1016/j.jss.2012.03.036 · Cited by 21
Plock, J. A., Frese, S., Keogh, A., Bisch-Knaden, S., Ayuni, E., Corazza, N., Weikert, C., Jakob, S. M., Erni, D., Dufour, J., et al. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.04.016 · Cited by 21
An adipocentric view of liver fibrosis and cirrhosis.
Chuang, J., Wang, P., & Tai, M.-H. (2004) · PubMed · Cited by 21
Gallucci, R. M., Sloan, D. K., O'Dell, S. J., & Reinke, L. A. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000118316.20560.0d · Cited by 21
Sahu, R., Goswami, S., Sastry, G. N., & Rawal, R. K. (2023) · Chemistry & Biodiversity · doi:10.1002/cbdv.202201029 · Cited by 20
Kirchmeyer, M., Servais, F., Hamdorf, M., Nazarov, P. V., Ginolhac, A., Halder, R., Vallar, L., Glanemann, M., Rubie, C., Lammert, F., et al. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.ma1217-499rr · Cited by 22
Effects of transmitters and interleukin-10 on rat hepatic fibrosis induced by CCl4
Wang, X. (2003) · World Journal of Gastroenterology · doi:10.3748/wjg.v9.i3.539 · Cited by 20
Metadata
- Authors
- Kovalovich, K., DeAngelis, R. A., Li, W., Furth, E. E., Ciliberto, G., & Taub, R.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Taub, Rebecca
- Venue
- Hepatology
- Published
- 2000-01
- Volume
- 31
- Issue
- 1
- Pages
- 149-159
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2009008191
- Cited by
- 298
- References
- 56
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 11 · 2022: 8 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 8 · 2017: 13 · 2016: 13 · 2015: 9 · 2014: 11 · 2013: 11 · 2012: 12
- FWCI
- 17.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1k08dk002667-01, 5r01dk049629-05)
- National Institute of Diabetes and Digestive and Kidney Diseases (F32DK009732, DK-49629, 1 K08 DK 02667-01, 1 F32 DK09732-01)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Keywords
- interleukin-6, liver injury, liver fibrosis, carbon tetrachloride, hepatocyte apoptosis, liver regeneration, STAT3, NF-κB, hepatic stellate cells, alpha-smooth muscle actin, phenobarbital, hepatocyte DNA synthesis, wound healing
- MeSH terms
- Actins, Animals, Carbon Tetrachloride, DNA, DNA-Binding Proteins, Kinetics, Liver Cirrhosis, Experimental, Mice, Inbred C57BL, Mitosis, Phenobarbital, Trans-Activators, Interleukin-6, NF-kappa B, Apoptosis, Mice, Knockout, STAT3 Transcription Factor, Mice, Chemical and Drug Induced Liver Injury
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